Lifeboat Foundation

We acquired a rapidly preserved human surgical sample from the temporal lobe of the cerebral cortex. We stained a 1 mm³ volume with heavy metals, embedded it in resin, cut more than 5,000 slices at ∼30 nm and imaged these sections using a high-speed multibeam scanning electron microscope. We used computational methods to render the three-dimensional structure containing 57,216 cells, hundreds of millions of neurites and 133.7 million synaptic connections. The 1.4 petabyte electron microscopy volume, the segmented cells, cell parts, blood vessels, myelin, inhibitory and excitatory synapses, and 104 manually proofread cells are available to peruse online. Many interesting and unusual features were evident in this dataset. Glia outnumbered neurons 2:1 and oligodendrocytes were the most common cell type in the volume. Excitatory spiny neurons comprised 69% of the neuronal population, and excitatory synapses also were in the majority (76%). The synaptic drive onto spiny neurons was biased more strongly toward excitation (70%) than was the case for inhibitory interneurons (48%). Despite incompleteness of the automated segmentation caused by split and merge errors, we could automatically generate (and then validate) connections between most of the excitatory and inhibitory neuron types both within and between layers. In studying these neurons we found that deep layer excitatory cell types can be classified into new subsets, based on structural and connectivity differences, and that chandelier interneurons not only innervate excitatory neuron initial segments as previously described, but also each other’s initial segments. Furthermore, among the thousands of weak connections established on each neuron, there exist rarer highly powerful axonal inputs that establish multi-synaptic contacts (up to ∼20 synapses) with target neurons. Our analysis indicates that these strong inputs are specific, and allow small numbers of axons to have an outsized role in the activity of some of their postsynaptic partners.

The authors have declared no competing interest.

Patients with growth hormone receptor deficiency, or Laron syndrome, appear to have lower than average risk factors for cardiovascular disease, according to a new study.

A new study highlights possible cardiovascular health advantages in individuals with a rare condition known as growth hormone receptor deficiency (GHRD), also called Laron syndrome.

GHRD, which is characterized by the body’s impaired ability to use its own growth hormone and results in stunted growth, has been linked in mice to a record 40% longevity extension and lower risks for various age-related diseases. However, the risk of cardiovascular disease in individuals with GHRD has remained unclear until now, leading to the speculation that in people, this mouse longevity mutation may actually increase cardiovascular disease.

A joint team of physicists from Skoltech, MIPT, and ITMO developed an optical component that helps manage the properties of a terahertz beam and split it into several channels. The new device can be used as a modulator and generator of terahertz vortex beams in medicine, 6G communications, and microscopy. The paper appears in the journal Advanced Optical Materials.

The shimmering of butterfly wings in bright colors does not emerge from pigments. Rather, photonic crystals are responsible for the play of colors. Their periodic nanostructure allows light at certain wavelengths to pass through while reflecting other wavelengths. This causes the wing scales, which are in fact transparent, to appear so magnificently colored.

Here’s a nice article discussing the progress of the brain-computer interface industry, some existing startups in the space, and where the industry may go in the future.

Fifty years after the term brain–computer interface was coined, the neurotechnology is being pursued by an array of start-up companies using a variety of different technologies. But the path to clinical and commercial success remains uncertain.

Australian researchers have shed light on the shape-shifting capabilities of protein assemblies, with results that could revolutionize fields from biomanufacturing to vaccine development.

The transcript features an interview with renowned science fiction author Isaac Asimov, discussing his predictions and visions for the future of space exploration, computers, robotics, and humanity’s role in shaping that future. It touches on concepts like permanent space settlements, harnessing solar power, the increasing importance of computers and AI, the impacts of robotics on jobs, and taking an optimistic yet cautionary view of technological progress. It also covers some earlier inaccurate and exaggerated predictions about robots replacing humans, as well as actual technological developments in 1982 like artificial hearts and fusion reactors. The overall theme is Asimov’s hopeful but measured outlook on future scientific and technological advancements.

New Year’s Eve is often a night filled with celebratory shots and champagne toasts. But as the party night fast approaches, one doctor is gently reminding folks the importance of partying responsibly during the holidays. Really, it’s a piece of advice that’s important all year long.

Dr. Brian Hoeflinger, an Ohio based neurosurgeon with over two decades of experience, has a TikTok channel filled with educational videos and lifestyle tips. But it’s his latest clip explaining just how long it takes our bodies to break down alcohol that has gone viral.

In the video, which was shared on Christmas Day, Dr. Hoeflinger sets the scene of a party where “a lot of drinks are going down” by setting up a bunch of shot glasses filled with water.

Over 350 million surgeries are performed globally each year. For most of us, it’s likely at some point in our lives we’ll have to undergo a procedure that needs general anaesthesia.

Even though it is one of the safest medical practices, we still don’t have a complete, thorough understanding of precisely how anaesthetic drugs work in the brain.

In fact, it has largely remained a mystery since general anaesthesia was introduced into medicine over 180 years ago.