Lifeboat Foundation

Anyone who has left youth behind them knows that bumps and scrapes don’t heal as fast as they used to. But that could change with researchers at the Stem Cell Program at Boston Children’s Hospital finding a way to regrow hair, cartilage, bone, skin and other soft tissues in a mouse by reactivating a dormant gene called Lin28a. The discovery could lead to new treatments that provide adults with the regenerative powers they possessed when very young.

Lin28 is a gene that is abundant in embryonic stem cells and which functions in all organisms. It is thought to regulate the self-renewal of stem cells with the researchers finding that by promoting the production of certain enzymes in mitochondria, it enhances the metabolism of these cellular power plants that found in most of the cells of living organisms. In this way, Lin28 helps generate the energy needed to stimulate the growth of new tissues.

Continue reading “Hair, bone and soft tissue regrown in mice by enhancing cell metabolism” »

A University of Alabama at Birmingham (UAB) surgical team has performed one of the first surgeries using a telepresence augmented reality technology from VIPAAR in conjunction with Google Glass.

The combination of the two technologies could be an important step toward the development of useful, practical telemedicine.

VIPAAR (Virtual Interactive Presence in Augmented Reality) is commercializing a UAB-developed technology that provides real-time, two-way, interactive video conferencing.

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In is now quite clear that aging is not a simple phenomenon and it will not be overcome by using simple approaches. We need to increase the complexity and sophistication of our efforts in order to be in a better position to develop strategies against it. For this reason, I set up the ELPIS Foundation for Indefinite Lifespans (www.elpisfil.org) which is a scientific research organisation aiming to study aging from a complex evolutionary perspective.

The foundation’s research methodology is based mainly upon the ELPIS hypothesis (www.elpistheory.info). The initials stand for ‘Extreme Lifespans through Perpetual –equalising Interventions’. I developed this hypothesis in 2010 whilst trying to examine the reason behind the presence of aging. It was clear that aging is not an essential component of our evolutionary development, and if we find ways to study why nature has developed it, we may then be able to eradicate it. Currently, the chances of us dying from aging are heavily against us. By developing suitable interventions, we may be able to equalise the odds against us dying (i.e. remove aging as a cause of death).

Our method is different from most existing approaches aiming to eliminate aging. We are mainly interested in the ‘connection-approach’ and not so much in the ‘component-approach’. We believe that it is important to study how the different components of the organism are interconnected and regulated, rather than just repair the individual components. It is the ‘why aging happens’ rather than the ‘how it happens’ that interests us most. In order to make this clear let me mention an analogy with poliomyelitis.

Polio
*How it happens? There is inflammation and necrosis leading to damage of motor neurons and, ultimately, muscle weakness and paralysis
* Why it happens? Because the poliovirus causes it

Continue reading “Defying Aging: The ELPIs Foundation for Indefinite Lifespans” »

By Avi Roy, University of Buckingham and Anders Sandberg, University of Oxford

Men who are unemployed for more than two years show signs of faster ageing in their DNA, according to a study published today in the journal PLOS ONE.

Researchers at the University of Oulu, Finland and Imperial College, London arrived at this conclusion by studying blood samples collected from 5,620 men and women born in Northern Finland in 1966. The researchers measured the lengths of telomeres in their white blood cells, and compared them with the participants’ employment history for the prior three years, and found that extended unemployment (more than 500 days in three years) was associated with shorter telomere length.

Telomeres are repetitive DNA sequences at the ends of chromosomes, which protect the chromosomes from degrading. With every cell division, it appears that these telomeres get shorter. And the result of each shortening is that these cells degrade and age.

Continue reading “Do unemployed people age faster?” »

Grindhouse Wetware is a collective of makers and engineers founded on a basic principle – human augmentation should be accessible and open. All of our devices are built off of open source platforms. This allows our users to peer into the hardware and code of their implanted device and truly control their augmented experience. Grindhouse Wetware’s devices are tailored to Makers and DIY Transhumanists that want to build a specific, unique augmentation. What do you want to be?

After three years of development, our flagship project – Circadia, is in its final stages. Grindhouse Wetware is seeking financial support from individuals or organizations to facilitate the production of this device.

The Circadia implant records bio-medical data and transmits it to the user’s phone via bluetooth. Instead of a snapshot of the user’s state of health, the Circadia records the up-to-date status of the their well being. Grindhouse Wetware firmly believes that once an implant has been installed in an individual, it becomes a part of their person. As such, the data generated by the Circadia belongs to the user.

If you are interested in supporting Grindhouse Wetware and the Circadia implant, please contact me at [email protected] or 631−715−9209

Continue reading “Grindhouse Wetware — Support Open Source Transhumanism” »

Containing more than 160 essays from over 40 contributors, this edited volume of essays on the science, philosophy and politics of longevity considers the project of ending aging and abolishing involuntary death-by-disease from a variety of viewpoints: scientific, technological, philosophical, pragmatic, artistic. In it you will find not only information on the ways in which science and medicine are bringing about the potential to reverse aging and defeat death within many of our own lifetimes, as well as the ways that you can increase your own longevity today in order to be there for tomorrow’s promise, but also a glimpse at the art, philosophy and politics of longevity as well – areas that will become increasingly important as we realize that advocacy, lobbying and activism can play as large a part in the hastening of progress in indefinite lifespans as science and technology can.

The collection is edited by Franco Cortese. Its contributing authors include William H. Andrews, Ph.D., Rachel Armstrong, Ph.D., Jonathan Betchtel, Yaniv Chen, Clyde DeSouza, Freija van Diujne, Ph.D., John Ellis, Ph.D., Linda Gamble, Roen Horn, the International Longevity Alliance (ILA), Zoltan Istvan, David Kekich (President & C.E.O of Maximum Life Foundation), Randal A. Koene, Ph.D., Maria Konovalenko, M.Sc. (Program Coordinator for the Science for Life Extension Foundation), Marios Kyriazis, MD, M.Sc MIBiol, CBiol (Founder of the ELPIs Foundation for Indefinite Lifespans and the medical advisor for the British Longevity Society), John R. Leonard (Director of Japan Longevity Alliance), Alex Lightman, Movement for Indefinite Life Extension (MILE), Josh Mitteldorf, Ph.D., Tom Mooney (Executive Director of the Coalition to Extend Life), Max More, Ph.D. , B.J. Murphy, Joern Pallensen, Dick Pelletier, Hank Pellissier (Founder of Brighter Brains Institute), Giulio Prisco, Marc Ransford, Jameson Rohrer, Martine Rothblatt, Ph.D., MBA, JD., Peter Rothman (editor-in-chief of H+ Magazine), Giovanni Santostasi, Ph.D (Director of Immortal Life Magazine, Eric Schulke, Jason Silva , R.U. Sirius, Ilia Stambler, Ph.D (activist at the International Longevity Alliance), G. Stolyarov II (editor-in-chief of The Rational Argumentator), Winslow Strong, Jason Sussberg, Violetta Karkucinska, David Westmorland, Peter Wicks, Ph.D, and Jason Xu (director of Longevity Party China and Longevity Party Taiwan).

Available on Amazon today!

By Avi Roy, University of Buckingham

In his essay “Fifty Years Hence”, Winston Churchill speculated, “We shall escape the absurdity of growing a whole chicken in order to eat the breast or wing, by growing these parts separately under a suitable medium.”

At an event in London today, the first hamburger made entirely from meat grown through cell culture will be cooked and consumed before a live audience. In June at the TED Global conference in Edinburgh, Andras Forgacs took a step even beyond Churchill’s hopes. He unveiled the world’s first leather made from cells grown in the lab.

These are historic events. Ones that will change the discussion about lab-grown meat from blue-skies science to a potential consumer product which may soon be found on supermarket shelves and retail stores. And while some may perceive this development as a drastic shake-up in the world of agriculture, it really is part of the trajectory that agricultural technology is already following.

Continue reading “Meat grown in labs is the next logical step for food production” »

Immortal Life has complied an edited volume of essays, arguments, and debates about Immortalism titled Human Destiny is to Eliminate Death from many esteemed ImmortalLife.info Authors (a good number of whom are also Lifeboat Foundation Advisory Board members as well), such as Martine Rothblatt (Ph.D, MBA, J.D.), Marios Kyriazis (MD, MS.c, MI.Biol, C.Biol.), Maria Konovalenko (M.Sc.), Mike Perry (Ph.D), Dick Pelletier, Khannea Suntzu, David Kekich (Founder & CEO of MaxLife Foundation), Hank Pellissier (Founder of Immortal Life), Eric Schulke & Franco Cortese (the previous Managing Directors of Immortal Life), Gennady Stolyarov II, Jason Xu (Director of Longevity Party China and Longevity Party Taiwan), Teresa Belcher, Joern Pallensen and more. The anthology was edited by Immortal Life Founder & Senior Editor, Hank Pellissier.

This one-of-a-kind collection features ten debates that originated at ImmortalLife.info, plus 36 articles, essays and diatribes by many of IL’s contributors, on topics from nutrition to mind-filing, from teleomeres to “Deathism”, from libertarian life-extending suggestions to religion’s role in RLE to immortalism as a human rights issue.

The book is illustrated with famous paintings on the subject of aging and death, by artists such as Goya, Picasso, Cezanne, Dali, and numerous others.

The book was designed by Wendy Stolyarov; edited by Hank Pellissier; published by the Center for Transhumanity. This edited volume is the first in a series of quarterly anthologies planned by Immortal Life

Continue reading “Human Destiny is to Eliminate Death — Essays, Rants & Arguments on Immortalism (Edited Volume)” »

It may be possible one day to use effective biotechnological therapies in order to achieve extreme lifespans. In the meantime, instead of just waiting for these therapies, it may be more fruitful to live a life of constant stimulation, hyper-connection and avoidance of regularity. This is something that everybody can do today, and may have a direct impact upon radical life extension, not only for the individual but also for society.

For some time now I have been advocating the notion that exposure to meaningful information may be one way of achieving radical life extension. By meaningful information I mean anything that requires action, and not just feeding your brain with routine sets of data. Examples of this include being hyper-connected in a digital world, an enriched environment (both in the personal space and in society as a whole), a hormetic lifestyle, behavioural models such as a goal-seeking behaviour, search for excellence, and a bias for action, as well as the pursuit innovation, diversification, creativity and novelty. Most importantly, the avoidance of routine and mediocrity.

This information-rich lifestyle up-regulates the function of the brain and may have an impact upon cell immortalisation. In my latest paper (http://arxiv.org/abs/1306.2734 I provide an explanation of the exact mechanisms. I argue that the relentless exposure to useful information creates new and persisting demands for energy resources in order for this information to be assimilated by the neurons. If this process continues for some time, there will come a point where our biological mechanisms will undergo a phase transition, in effect creating a new biology. Not one based on sex and reproduction but one based on information and somatic survival.

One possible mechanism involves the immortalisation sequences of germ cells. As we know, the DNA in germ cells is essentially immortal because it is somehow able to repair age-related damage effectively. Recent research shows that some of these immortalisation mechanisms do not originate from the germ cells but from the somatic cells! In other words, our bodily cells create biological material such as error-free sequences of DNA and instead of using this themselves for their own survival, they pass it on to the germ cells to assure the survival of the species. This means that the germ-line remains immortal whereas the bodily cells eventually age and die.

Continue reading “Extreme Lifespans via Exposure to Information” »