Babies born very early had stronger neurodevelopmental performance at 1 year if they received more skin-to-skin care as newborns, a Stanford Medicine study found.
Category: biotech/medical – Page 33
Generative AI develops potential new drugs for antibiotic-resistant bacteria
By Rachel Tompa
Stanford Medicine researchers devise a new artificial intelligence model, SyntheMol, which creates recipes for chemists to synthesize the drugs in the lab.
BRCA2 research reveals a novel mechanism behind chemoresistance
One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often limited.
A research team led by Arnab Ray Chaudhuri at the Department of Molecular Genetics, Erasmus MC Cancer Institute has now uncovered a mechanism by which BRCA2-deficient tumors develop this resistance. The proteins BRCA2 and FIGNL1 appear to have a different function than previously assumed.
“These findings change the paradigm of thought,” says Ray Chaudhuri. The team also identified ways to reverse or prevent resistance.
THE FOREST KING | Red Iron Road | Full Episode
Set in a suffocating, over-commercialized future, a young boy’s desire for success and status leads him into a terrifying and deadly new reality through the lens of a mysterious VR game.
His desperate father must now race against both time and technology to save his dying son.
But the boy is the only one who can save himself — before becoming another faceless pawn of the Forest King.
Adapted from the poem “The Forest Tsar” (1818) by Vasiliy Zhukovsky.
🎬 THE FOREST KING
The second installment of the animated horror anthology RED IRON ROAD.
Each episode is a standalone short film (10–20 minutes) inspired by European literature, produced with unique creative partners in distinctive visual styles.
🏆 Festival Highlights.
• World Premiere – Nightmares Film Festival (Ohio, USA, 2022)
• Nominations – FilmQuest, Blood in the Snow Film Festival, Animaze.
🌐 Official Sites:
https://www.lakesideanimation.com/for… 🎥 Credits Directed & Written By: Lubomir Arsov Produced By: Lakeside Animation Animation By: Art Light & Riki Group (Petersburg Animation Studio) Musical Score By: Lars Korb Starring: Carlo Rota, Tom Rooney, Jaiden Cannatelli 📖 Full Cast & Crew: https://www.imdb.com/title/tt23845934… 📺 Where to Watch Season 1 of Red Iron Road: Amazon Prime Video (subscription required): https://www.primevideo.com/detail/0PB… TubiTV (free streaming): https://tubitv.com/movies/100014990/r… Plex (free streaming): https://tubitv.com/movies/100014990/r… Hoopla Digital (free with library card): https://www.hoopladigital.com/televis… Kanopy (free via library or university): https://www.kanopy.com/en/product/140… Apple TV (subscription to Prime Video required): https://tv.apple.com 🔔 Subscribe for new animated horror shorts and exclusive content! Follow Red Iron Road & Lakeside Animation: Facebook: / redironroadseries Instagram:
/ redironroadseries TikTok:
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/ lakeside-animation 🔖 Hashtags: #RedIronRoad #AdultAnimation #Games #Anthology #Animation #AnimatedAnthology #HorrorAnimation #SlavicMythology #AnimatedShortFilm #LakesideAnimation #EuropeanHorror #AnimationStudio #FolkHorror #AnimatedHorror #CreepyTales #ClassicLiterature #AnimationForAdults © 2022 Ghost Train Productions Inc.
Scientists reverse Alzheimer’s in mice with groundbreaking nanotech
Researchers used supramolecular nanoparticles to repair the brain’s vascular system and reverse Alzheimer’s in mice. Instead of carrying drugs, the nanoparticles themselves triggered natural clearance of amyloid-β proteins. This restored blood-brain barrier function and reversed memory loss. The results point to a revolutionary new path for treating neurodegenerative diseases.
Powerful New Antibiotic Was ‘Hiding in Plain Sight’ For Decades
Researchers have just identified a powerful new antibiotic – in a significant discovery made not by breaking new ground, but by revisiting familiar territory.
The compound, pre-methylenomycin C lactone, was discovered by a team from Warwick University in the UK and Monash University in Australia. While it’s never been spotted before, it comes from a type of bacteria that scientists have studied for decades.
Potentially, it could help fight bacteria that have become increasingly resistant to modern treatments – and it’s actually an intermediate chemical that’s created during the process of making another antibiotic, methylenomycin A.
Will nasal vaccines consign injections to history?
It’s hard to think of vaccination without associating it with a sharp jab in the arm. But there are other, more gentle ways of activating the immune system, such as administering vaccines via the nose. Now, researchers at Chiba University, in Chiba prefecture, Japan, and the pharmaceutical company Shionogi have joined forces to explore the exciting potential of nasal vaccines.
One of the most compelling reasons for pursuing nasal vaccines is that they could offer protection against airborne pathogens at their entry point, before they take hold deeper in the body. That’s the role of the mucosal immune system, associated with the mucosal surfaces that line the nose, mouth, airway, digestive tract and genitals. It’s one of the body’s first lines of defence against external threats.
The mucosal immune system is most evident when experiencing the aggravating symptoms that accompany hay fever, such as uncontrollable sneezing, a runny nose and itchy eyes. These are responses of an activated mucosal immune system as it desperately tries to flush or defuse harmless pollen grains from the nasal cavity and eyes.
Chemists design candidate drug against diabetes
Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.
The breakthrough could offer a new therapeutic option for stopping the harmful effects of both type 1 and type 2 diabetes at the source.
In their latest work, the researchers successfully identified—and developed a small molecule drug to disrupt—an intracellular chain reaction that is a major contributor to diabetes-induced complications. Their findings, published earlier this month, were featured on the cover of Cell Chemical Biology.
Detailed brain growth atlas in mice offers insights into brain development
Brain growth and maturation doesn’t progress in a linear, stepwise fashion. Instead, it’s a dynamic, choreographed sequence that shifts in response to genetics and external stimuli like sight and sound. This is the first high-resolution growth chart to explain changes of key brain cell types in the developing mouse brain, led by a team at Penn State College of Medicine and the Allen Institute for Brain Science.
Using advanced imaging techniques, the researchers constructed a series of 3D atlases that are like time-lapsed maps of the brain during its first two weeks after birth, offering an unparalleled look at a critical period of brain development. It’s a powerful tool to understand healthy brain development and neurodevelopmental disorders, the researchers explained.
The study, published in Nature Communications, also detailed how regions of the brain change in volume and explained the shift in density of key cell types within them.