Lifeboat Foundation

A new vaccine designed to prime the immune system to recognise and fight lung cancer has been tested on UK patients for the first time.

Researchers leading the trial have said that BioNTech’s BNT116 vaccine could improve survival rates among people with the disease, and hope that it could eventually become the standard of care worldwide.

It works by presenting the immune system with tumour markers from non-small cell lung cancer, the most common form of the disease, to prime the body to fight cancer cells expressing these markers.

Biotechnology firm United Therapeutics has showcased what it claims to be the “world’s most complex 3D printed object” in partnership with 3D printer manufacturer 3D Systems at the recent LIFE ITSELF conference in San Diego.

The partners have produced a 3D printed human lung scaffold capable of demonstrating gas exchange in animal models, and are now planning to cellularize the scaffold with a patient’s own stem cells to create tolerable, transplantable human lungs.

“Last week, it was exciting to show the public our 3D printed human lung scaffold, but we’re thrilled to share that our 3D printed lung scaffolds are now demonstrating gas exchange in animal models,” said Dr. Martine Rothblatt, United Therapeutics’ Chairperson and CEO. “We are regularly printing lung scaffolds as accurately as driving across the United States and not deviating from a course by more than the width of a human hair.

This research uncovers diverse neural roles in processing words and complex sentences.

MIT neuroscientists have identified several brain regions responsible for processing language using functional magnetic resonance imaging (fMRI).

However, discovering the specific functions of neurons in those regions has proven difficult because fMRI, which measures changes in blood flow, doesn’t have a high resolution to reveal what small populations of neurons are doing.

Continue reading “New MIT study finds neurons process language at varied timescales” »

What does the future hold? What will become of this planet and its inhabitants in the centuries to come?
We are living in a historical period that sometimes feels like the prelude to something truly remarkable or terribly dire about to unfold.
This captivating video seeks to decipher the signs and attempt to construct plausible scenarios from the nearly nothing we hold in our hands today.
As always, it will be scientific discoveries leading the dance of change, while philosophers, writers, politicians, and all the others will have the seemingly trivial task of containing, describing, and guiding.
Before embarking on our journey through time, let me state the obvious: No one knows the future!
Numerous micro and macro factors could alter this trajectory—world wars, pandemics, unimaginable social shifts, or climate disasters.
Nevertheless, we’re setting off. And we’re doing so by discussing the remaining decades of the century we’re experiencing right now.

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DISCUSSIONS \& SOCIAL MEDIA

Continue reading “From Today To The Year 3000: Let’s Dive Into The Future!” »

Scientists at Northwestern University say they’ve invented a goo — yes, a goo — that could open the door to regenerating human knee cartilage, a finding that could eventually lead to new clinical ways to rebuild knee joints and avoid invasive and expensive knee replacement surgeries.

Cartilage is the connective tissue that wraps around joints and bones, working to absorb shock, aid mobility, and protect against painful bone-on-bone friction. These are all tough — and important! — jobs, and yet cartilage doesn’t naturally regenerate on its own. As a result, those with worn-down or damaged cartilage often wind up turning to knee replacement surgery. While effective, that road can be expensive and generally requires a lengthy recovery period.

That’s where the goo might come in.

Adeno-associated virus (AAV) has found immense success as a delivery system for gene therapy, yet the small 4.7 kb packaging capacity of the AAV sharply limits the scope of its application. In addition, high doses of AAV are frequently required to facilitate therapeutic effects, leading to acute toxicity issues. While dual and triple AAV approaches have been developed to mitigate the packaging capacity problem, these necessitate even higher doses to ensure that co-infection occurs at sufficient frequency. To address these challenges, we herein describe a novel delivery system consisting of adenovirus (Ad) covalently linked to multiple adeno-associated virus (AAV) capsids as a new way of more efficiently co-infecting cells with lower overall amounts of AAVs. We utilize the DogTag-DogCatcher (DgT-DgC) molecular glue system to construct our AdAAVs and we demonstrate that these hybrid virus complexes achieve enhanced co-transduction of cultured cells. This technology may eventually broaden the utility of AAV gene delivery by providing an alternative to dual or triple AAV which can be employed at lower dose while reaching higher co-transduction efficiency.

Although adeno-associated virus (AAV) gene therapy has shown enormous promise and led to five clinically approved treatments,^1–3 it is consistently hampered by the vector’s low DNA packaging capacity of 4.7 kb. Great effort has gone into developing dual AAV systems, which deliver two parts of a therapeutic gene in separate capsids that aim to co-infect the same cells.^4–7 Analogous triple AAV systems have also been explored.^8,9 Dual and triple AAV systems can recombine their split genes into complete form through mechanisms of DNA trans-splicing, RNA trans-splicing, or protein splicing via split inteins.^5,7 However, dual and triple AAVs typically require higher doses to achieve efficient co-transduction of cells, especially when systemic administration is necessary.¹⁰ This makes sense since the likelihood of two or three cargos reaching the same cell should roughly correspond to the proportion of a single cargo reaching the cell squared or cubed respectively.

A new Nature Human Behaviour study, jointly led by Dr. Margherita Malanchini at Queen Mary University of London and Dr. Andrea Allegrini at University College London, has revealed that non-cognitive skills, such as motivation and self-regulation, are as important as intelligence in determining academic success. These skills become increasingly influential throughout a child’s education, with genetic factors playing a significant role.

The research, conducted in collaboration with an international team of experts, suggests that fostering non-cognitive skills alongside cognitive abilities could significantly improve educational outcomes.

“Our research challenges the long-held assumption that intelligence is the primary driver of academic achievement,” says Dr. Malanchini, Senior Lecturer in Psychology at Queen Mary University of London.

The CDC warned of increasing viral activity on the heels of “unusually high numbers of cases” in Europe earlier this year.

A novel, water-resistant patch-wearable cardioverter-defibrillator (P-WCD) is safe and effective for patients at risk for sudden cardiac arrest, according to a study published in the Aug. 6 issue of the Journal of the American College of Cardiology.

John Hummel, M.D., from The Ohio State University in Columbus, and colleagues assessed the safety and clinical effectiveness of a novel P-WCD. The analysis included 290 patients at risk for sudden cardiac arrest due to ventricular tachycardia/ventricular fibrillation who were not candidates for or refused an implantable defibrillator.

The researchers found that the clinically significant cutaneous adverse device effect rate was 2.30 percent, with no severe adverse effects. There were no device-related deaths or serious adverse events reported. The inappropriate shock rate was 0.36 per 100 patient-months. Nine patients received 11 shocks, of which nine shocks were adjudicated to be appropriate. Eight of nine appropriate shocks were successful with a single shock. Median wear time compliance was 23.5 hours per day.