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Category: biotech/medical – Page 5

Brain tumor growth patterns may help inform patient care management

As brain tumors grow, they must do one of two things: push against the brain or use finger-like extensions to invade and destroy surrounding tissue.

Previous research found that tumors that push—or put mechanical force on the brain—cause more neurological dysfunction than tumors that destroy tissue. But what else can these different tactics of tumor growth tell us?

Now, the same team of researchers from the University of Notre Dame, Harvard Medical School/Massachusetts General Hospital, and Boston University has developed a technique for measuring a brain tumor’s mechanical force and a new model to estimate how much brain tissue a patient has lost. Published in Clinical Cancer Research, the study explains how these measurements may help inform patient care and be adopted into surgeons’ daily workflow.

BCI robotic hand control reaches new finger-level milestone

As detailed in a new study in Nature Communications, He’s lab brings noninvasive EEG-based BCI one step closer to everyday use by demonstrating real-time brain decoding of individual finger movement intentions and control of a dexterous robotic hand at the finger level.

“Improving hand function is a top priority for both impaired and able-bodied individuals, as even small gains can meaningfully enhance ability and quality of life,” explained Bin He, professor of biomedical engineering at Carnegie Mellon University. “However, real-time decoding of dexterous individual finger movements using noninvasive brain signals has remained an elusive goal, largely due to the limited spatial resolution of EEG.”

Functional Features of Senescent Cells and Implications for Therapy

Cellular senescence is a key mechanism of aging. Senescent cells negatively affect the function of tissues and organs, significantly contributimg to the aging of the organism. Functional and structural characteristics of senescent cells, such as genomic changes and cell cycle arrest, lysosome and mitochondrial dysfunction, and production of SASP factors, are promising therapeutic targets in the context of healthy longevity. The present review was designed to characterize the features of senescent cells in order to discuss current methods and problems of geroprotective therapy and perspective factors for the development of new strategies of anti-aging treatment. Publications were searched based on the analysis of articles containing the keywords “senescent cells, aging, senolytic therapy, SASP, mitochondrial dysfunction” in the PubMed and Scopus databases up to March 2025.

Danish trial reveals how structured exercise and guidance affect life with chronic conditions

A large multicenter trial found that a 12-week personalized exercise therapy and self-management support program produced a small but statistically significant improvement in health-related quality of life for adults with multimorbidity. The intervention was safe, but its clinical relevance remains uncertain, as only self-rated health showed a significant benefit over usual care.

Chinese scientists find genetics shapes brain’s balance linked to mental ability

There is extensive evidence that brain criticality – the balance between neural excitation and inhibition – enhances its information processing capabilities.

But despite the significance of brain criticality and its potential influence on neurological and psychiatric disorders, the genetic basis of this state had been “largely unexplored”, according to researchers from the Chinese Academy of Sciences’ biophysics and automation institutes. “We demonstrate that genetic factors significantly influence brain criticality across various scales, from specific brain regions to large-scale networks,” the team said in their paper published in the peer-reviewed journal Proceedings of the National Academy of Sciences last month.

They also established a link between criticality and cognitive functions, suggesting a shared genetic foundation.

“These findings position brain criticality as a biological phenotype, opening broad avenues for exploring its implications in brain function and potential dysfunctions,” the team wrote.

Brain criticality is characterised by neuronal avalanches, or cascading bursts of neuron activity in brain networks.

“At the critical state, the brain exhibits scale-free dynamics, with avalanches observed across various scales ranging from local networks of individual neurons to the global network of interacting brain areas,” the paper said.

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Surprise Discovery About Sugar in The Brain Could Help Fight Alzheimer’s

Stores of glucose in the brain could play a much more significant role in the pathological degeneration of neurons than scientists realized, opening the way to new treatments for conditions like Alzheimer’s disease.

Alzheimer’s is a tauopathy; a condition characterized by harmful build-ups of tau proteins inside neurons. It’s not clear, however, if these build-ups are a cause or a consequence of the disease. A new study now adds important detail by revealing significant interactions between tau and glucose in its stored form of glycogen.

Led by a team from the Buck Institute for Research on Aging in the US, the research sheds new light on the functions of glycogen in the brain. Before now, it’s only been regarded as an energy backup for the liver and the muscles.