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Category: biotech/medical – Page 5
TARA-002 Overview TARA-002 is an investigational cell therapy in development for the treatment of non-mu…
A new study led by researchers at the Earth-Life Science Institute (ELSI) at the Institute of Science, Tokyo, has uncovered a surprising role for calcium in shaping life’s earliest molecular structures. Their findings suggest that calcium ions can selectively influence how primitive polymers form, shedding light on a long-standing mystery: how life’s molecules came to prefer a single “handedness” (chirality).
The study is published in Proceedings of the National Academy of Sciences.
Like our left and right hands, many molecules exist in two mirror-image forms. Yet life on Earth has a striking preference: DNA’s sugars are right-handed, while proteins are built from left-handed amino acids. This phenomenon, called homochirality, is essential for life as we know it—but how it first emerged remains a major puzzle in origins of life research.
A sensitive, flexible, and cost-effective solution takes the guesswork out of DNA methylation profiling.
Hypoxic Preconditioning Enhances the Potential of Mesenchymal Stem Cells to Treat Neonatal Hypoxic-Ischemic Brain Injury
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About 20% to 35% of the population suffers from chronic sleep disorders—and up to half of all people in older age. Moreover, almost every teenager or adult has experienced short-term sleep deprivation at some point. There are many reasons for not getting enough sleep, whether it be partying, a long day at work, caring for relatives, or simply whiling away time on smartphones.
In a recent meta-study, Jülich researchers have now been able to show that the brain regions involved in the short-term and long-term conditions differ significantly. The results of the study were published in the journal JAMA Psychiatry.
“Poor sleep is one of the most important—but changeable—risk factors for mental illnesses in adolescents and older people,” says Jülich researcher and Privatdozent Dr. Masoud Tahmasian, who coordinated the study. In contrast, long-term pathological sleep disorders, such as insomnia, obstructive sleep apnea, narcolepsy, and short-term sleep deprivation, are located in different parts of the brain.
Researchers at Indiana University have shown that an artificial intelligence framework that employs sequential decision-making could reduce healthcare costs by over 50 percent while also improving patient outcomes by over 40 percent. New research from Indiana University has found that machine lea
University of Pittsburgh School of Medicine scientists are one step closer to developing a brain-computer interface, or BCI, that allows people with tetraplegia to restore their lost sense of touch.
While exploring a digitally represented object through their artificially created sense of touch, users described the warm fur of a purring cat, the smooth rigid surface of a door key and the cool roundness of an apple. This research, a collaboration between Pitt and the University of Chicago, is published in Nature Communications.
In contrast to earlier experiments where artificial touch often felt like indistinct buzzing or tingling and didn’t vary from object to object, scientists gave BCI users control over the details of the electrical stimulation that creates tactile sensations, rather than making those decisions themselves. This key innovation allowed participants to recreate a sense of touch that felt intuitive to them.
Scientists using living human brain tissue have shown for the first time how a toxic form of a protein linked to Alzheimer’s can stick to and damage the connections between brain cells.
Small pieces of healthy human brain tissue —collected during routine neurosurgery operations—were exposed to the protein, known as amyloid beta.
Unlike when subjected to a normal form of the protein, the brain tissue did not attempt to repair damage caused by the toxic form of amyloid beta, experts say.
Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy
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Background and ObjectiveSeveral studies have shown that idiopathic normal-pressure hydrocephalus (iNPH) can mimic other neurodegenerative disorders, particularly progressive supranuclear palsy (PSP). In this study, we investigated iNPH clinical and…
A research team has uncovered a previously unknown type of immune signaling molecule—a novel compound combining histidine and ADP-ribose—produced by bacteria’s Thoeris II defense system in response to viral infection. This finding expands our understanding of bacterial immunity and may pave the way for innovative tools in biotechnology, gene editing, and antimicrobial therapy.
The paper, titled “TIR domains produce histidine-ADPR as an immune signal in bacteria,” is published in the journal Nature, and the team includes scientists at Vilnius University’s Life Sciences Centre (VU LSC), together with colleagues from the Weizmann Institute of Science (Israel) and Harvard Medical School.
The discovery sheds light on how bacteria, much like humans, communicate viral threats at the molecular level—in this case, triggering a self-sacrificing response to halt virus spread and protect bacterial populations. Beyond its fundamental significance, the finding opens exciting avenues for rethinking immune mechanisms and virus-host interactions.