Just as stiffened joints can hinder mobility, it appears the stem cells of hair follicles can also grow stiff, obstructing hair growth.
The Mayo Clinic has reportedly been testing the system since April.
Google’s Med-PaLM 2, an AI tool designed to answer questions about medical information, has been in testing at the Mayo Clinic research hospital, among others, since April, The Wall Street Journal.
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In January 2021, EPFL engineers announced in Advanced Science their concept of a novel cardiac assist device that is devoid of rigid metallic components. It consists of a soft, artificial muscle wrapped around the aorta that can constrict and dilate the vessel, ultimately enhancing the aorta’s natural function and aiding the heart to pump blood to the rest of the body.
Now June 2021, EPFL engineers led by Yves Perriard of the Laboratory of Integrated Actuators in collaboration with University of Bern, have successfully implanted their first artificial tubular muscle, in vivo, in a pig. During the 4-hour long operation, their cardiac assist device maintained 24 000 pulsations, of which 1,500 were activated artificially by the augmented aorta.
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Artificial intelligence algorithms, such as the sophisticated natural language processor ChatGPT, are raising hopes, eyebrows and alarm bells in multiple industries. A deluge of news articles and opinion pieces, reflecting both concerns about and promises of the rapidly advancing field, often note AI’s potential to spread misinformation and replace human workers on a massive scale. According to Jonathan Chen, MD, PhD, assistant professor of medicine, the speculation about large-scale disruptions has a kernel of truth to it, but it misses another element when it comes to health care: AI will bring benefits to both patients and providers.
Chen discussed the challenges with and potential for AI in health care in a commentary published in JAMA on April 28. In this Q&A, he expands on how he sees AI integrating into health care.
The algorithms we’re seeing emerge have really popped open Pandora’s box and, ready or not, AI will substantially change the way physicians work and the way patients interact with clinical medicine. For example, we can tell our patients that they should not be using these tools for medical advice or self-diagnosis, but we know that thousands, if not millions, of people are already doing it — typing in symptoms and asking the models what might be ailing them.
A genetic editing system similar to CRISPR-Cas9 has been uncovered for the first time in eukaryotes – the group of organisms that include fungi, plants, and animals. The system, based on a protein called Fanzor, can be guided to precisely target and edit sections of DNA, and that could open up the possibility of its use as a human genome editing tool.
The research team, led by Professor Feng Zhang at the McGovern Institute for Brain Research at MIT and the Broad Institute of MIT and Harvard, began to suspect that Fanzor proteins might act as nucleases – enzymes that can chop up nucleic acids, like DNA – during a previous investigation.
The arrangement of electrons in matter, known as the electronic structure, plays a crucial role in fundamental but also applied research, such as drug design and energy storage. However, the lack of a simulation technique that offers both high fidelity and scalability across different time and length scales has long been a roadblock for the progress of these technologies.
Researchers from the Center for Advanced Systems Understanding (CASUS) at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) in Görlitz, Germany, and Sandia National Laboratories in Albuquerque, New Mexico, U.S., have now pioneered a machine learning–based simulation method that supersedes traditional electronic structure simulation techniques.
Their Materials Learning Algorithms (MALA) software stack enables access to previously unattainable length scales. The work is published in the journal npj Computational Materials.
Interesting discovery! I’d love to see it in action.
A new ferroelectric polymer that efficiently converts electrical energy into mechanical strain has been developed by Penn State researchers. This material, showing potential for use in medical devices and robotics, overcomes traditional piezoelectric limitations. Researchers improved performance by creating a polymer nanocomposite, significantly reducing the necessary driving field strength, expanding potential applications.
A new type of ferroelectric polymer that is exceptionally good at converting electrical energy into mechanical strain holds promise as a high-performance motion controller or “actuator” with great potential for applications in medical devices, advanced robotics, and precision positioning systems, according to a team of international researchers led by Penn State.
Plants have the unique ability to regenerate entirely from a somatic cell, i.e., an ordinary cell that does not typically participate in reproduction. This process involves the de novo (or new) formation of a shoot apical meristem (SAM) that gives rise to lateral organs, which are key for the plant’s reconstruction.
At the cellular level, SAM formation is tightly regulated by either positive or negative regulators (genes/protein molecules) that may induce or restrict shoot regeneration, respectively. But which molecules are involved? Are there other regulatory layers that are yet to be uncovered?
To seek answers to the above questions, a research group led by Nara Institute of Science and Technology (NAIST), Japan studied the process in Arabidopsis, a plant commonly used in genetic research. Their research—which was published in Science Advances —identified and characterized a key negative regulator of shoot regeneration.
The mesh has already proved successful on fruit fly larvae in Minnesota, and with two species of mushroom coral in Hawaii and Australia. In Florida, Hagedorn and colleagues were trying it on Diploria labyrinthiformis, a kind of brain coral whose larvae are more than 100 times bigger than those of mushroom coral. In the first few attempts, rewarmed larvae were falling apart. Each larval size, Hagedorn was learning, needs its own version of the treatment. “We’re struggling a little bit to get this to work,” she says.
WHILE SCIENTISTS such as Bischof and Hagedorn wrestle with vitrification, others are seeking an easier route by avoiding ultralow temperatures that require large infusions of cryoprotectant and make rewarming so challenging.
At Harvard University and MGH, scientists are taking cues from nature to push tissues below freezing while holding back the ice. The wood frog (Rana sylvatica) is a champion of this realm. Found in much of North America, including the frigid Canadian Arctic, it can spring to life after spending months with as much as two-thirds of its body frozen at temperatures as low as −16°C.
Each time our cells divide, the protective caps that keep our chromosomes from fraying, called telomeres, lose a bit of their DNA. Telomeres shorten steadily as we age, but in certain medical conditions like dyskeratosis congenita, the process is accelerated.
“Your telomeres determine your lifeline; how long they are determines how old your body is,” says Becca Hudson, who was diagnosed with dyskeratosis congenita at age 14. “My telomere length was below the first percentile for my age.”
Trying out for cheerleading, 14-year-old Becca was pulled when testing found something amiss with her blood work. She had very low counts of platelets, red cells, and white cells. Her doctor called later that day and said she should be admitted that night to Boston Children’s Hospital.
