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Category: biotech/medical – Page 57

Brewing possibilities: Using caffeine to edit gene expression

What if a cup of coffee could help treat cancer? Researchers at the Texas A&M Health Institute of Biosciences and Technology believe it’s possible. By combining caffeine with the use of CRISPR—a gene-editing tool known as clustered regularly interspaced short palindromic repeats—scientists are unlocking new treatments for long-term diseases, like cancer and diabetes, using a strategy known as chemogenetics.

The work is published in the journal Chemical Science.

Yubin Zhou, professor and director of the Center for Translational Cancer Research at the Institute of Biosciences and Technology, specializes in utilizing groundbreaking tools and technology to study medicine at the cellular, epigenetic and genetic levels. Throughout his career and over 180 publications, he has sought answers to medical questions by using highly advanced tools like CRISPR and chemogenetic control systems.

Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs)

Here, Deepak A. Rao & team use mass cytometry immune profiling to identify T cell features in pre-treatment blood samples from patients that are associated with irAEs after ICI therapy.

1Division of Rheumatology, Inflammation, Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

2Division of Rheumatology, Hospital for Special Surgery and Weill Cornell Medicine, New York, New York, USA.

3Memorial Sloan Kettering Center and Weill Cornell Medical College, New York, New York, USA.

Capturing the moment of organelle handoff inside living cells

For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum (ER) and transition onto microtubule tracks inside living cells. This new finding reveals that the ER plays an active and dynamic role in steering intracellular traffic rather than serving as a passive factory. The study is published in the journal ACS Nano.

For the study led by Director Cho Minhaeng at the Center for Molecular Spectroscopy and Dynamics within the Institute for Basic Science and Professor Hong Seok-Cheol at Korea University, the research team captured in real time the moment an autophagosome—an organelle responsible for cellular recycling—moves from the ER onto a neighboring microtubule. This long-sought observation provides direct experimental evidence for how intracellular transport is coordinated at nanoscopic contact sites within the crowded environment of living cells.

Autophagy is an essential cellular process in which damaged proteins and aged organelles are enclosed by double-membrane structures and delivered for degradation and recycling. The importance of autophagy was recognized by the 2016 Nobel Prize in Physiology or Medicine awarded to Yoshinori Ohsumi. Although scientists have long proposed that autophagosomes are transferred from the ER to microtubules at specialized contact sites, direct real-time experimental evidence of this cellular “handoff” had remained out of reach—until now.

Novel nanomaterial uses oxidative stress to kill cancer cells

Scientists at Oregon State University have developed a new nanomaterial that triggers a pair of chemical reactions inside cancer cells, killing the cells via oxidative stress while leaving healthy tissues alone. The study led by Oleh and Olena Taratula and Chao Wang of the OSU College of Pharmacy appears in Advanced Functional Materials.

The findings advance the field of chemodynamic therapy (CDT), an emerging treatment approach based on the distinctive biochemical environment found in cancer cells. Compared to healthy tissues, malignant tumors are more acidic and have elevated concentrations of hydrogen peroxide, the scientists explain.

Conventional CDT works by using the tumor microenvironment to trigger the chemical production of hydroxyl radicals—molecules, made up of oxygen and hydrogen—with an unpaired electron. These reactive oxygen species are able to damage cells through oxidation by stealing electrons from molecules like lipids, proteins, and DNA.

Treatment of Stage IIB Seminoma in a Patient With Down Syndrome and Eisenmenger Syndrome: A Case Report

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Management of testicular germ cell tumors in patients with complex comorbidities remains challenging. We present a case of stage IIB seminoma in a patient with Down syndrome (DS) and Eisenmenger syndrome (ES).

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