Lifeboat Foundation

Researchers say they have been able to tap a new pool of organ donors to preserve and transplant their hearts: people whose hearts have stopped beating, resulting in so-called circulatory death.

Traditionally, the only people considered to be suitable organ donors were those who have been declared brain-dead but whose hearts and other organs have continued to function.

There’s another group that would be willing to donate if survival wasn’t possible: people who may have severe brain injuries but who are not brain-dead. In these cases, people are considered deceased when their hearts stop beating after withdrawal of life support, also called circulatory death.

To learn more about nose and sinus cancers, we spoke with head and neck surgeon Ehab Hanna, M.D.

What are the symptoms of nose and sinus cancers?

Early symptoms often mimic those of more common conditions, such as sinus infections and allergies. As a result, these cancers are often misdiagnosed.

Colorectal cancer screening can detect cancer early, giving you the greatest chance for successful treatment. While colonoscopy is the gold standard for colorectal cancer screening, you may be wondering when you should get your first test.

We spoke with gastroenterologist Mazen Alasadi, M.D., about the recommended age for colonoscopies.

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Continue reading “HsCRP: What’s Optimal, Which Factors May Reduce It?” »

Year 2022 Microfluidics could even enable large amounts of liquids to be transferred with minimal weight buy here it is used in organs on a chip.

Organs-on-chips are microfluidic systems containing miniature tissues with the aim of mimicking human physiology for a range of biomedical and therapeutic applications. Leung, de Haan et al. report practical tips to inform design and operational decisions during the implementation of organ-on-a-chip systems.

Year 2017 😗😁

Pathologists tested the ‘efforts’ of Wim Delvoye’s artwork, which replicates a human digestive system, to raise awareness of bowel cancer screening tests.

Year 2021 😗😁

MIT engineers, in collaboration with scientists at Cancer Research UK Manchester Institute, have developed a new way to grow tiny replicas of the pancreas, using either healthy or cancerous pancreatic cells. Their new models could help researchers develop and test potential drugs for pancreatic cancer, which is currently one of the most difficult types of cancer to treat.

Using a specialized gel that mimics the extracellular environment surrounding the pancreas, the researchers were able to grow pancreatic “organoids,” allowing them to study the important interactions between pancreatic tumors and their environment. Unlike some of the gels now used to grow tissue, the new MIT gel is completely synthetic, easy to assemble and can be produced with a consistent composition every time.

Continue reading “Engineers grow pancreatic ‘organoids’ that mimic the real thing” »

Year 2019 😗😁

Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human primary cells can potentially correlate clinical testing. Liver-on-a-chip can not only predict drug hepatotoxicity and drug metabolism, but also connect other artificial organs on the chip for a human-on-a-chip, which can reflect the overall effect of a drug. Engineering an effective liver-on-a-chip device requires knowledge of multiple disciplines including chemistry, fluidic mechanics, cell biology, electrics, and optics.

Year 2021

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.