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Category: biotech/medical – Page 598

Accumulation of advanced oxidation protein products promotes age-related decline of type H vessels in bone

Abstract. Type H vessels have been proven to couple angiogenesis and osteogenesis. The decline of type H vessels contributes to bone loss in the aging process. Aging is accompanied by the accumulation of advanced oxidation protein products (AOPPs). However, whether AOPP accumulation is involved in age-related decline of type H vessels is unclear. Here, we show that the increase of AOPP levels in plasma and bone were correlated with the decline of type H vessels and loss of bone mass in old mice. Exposure of microvascular endothelial cells to AOPPs significantly inhibited cell proliferation, migration, and tube formation, increased NADPH oxidase activity and excessive reactive oxygen species generation, upregulated the expression of vascular cell adhesion molecule-1 and intercellular cell adhesion molecule-1, and eventually impaired angiogenesis, which was alleviated by redox modulator N-acetylcysteine and NADPH oxidase inhibitor apocynin. Furthermore, reduced AOPP accumulation by NAC treatment was able to alleviate significantly the decline of type H vessels, bone mass loss and deterioration of bone microstructure in old mice. Collectively, these findings suggest that AOPPs accumulation contributes to the decline of type H vessels in the aging process, and illuminate a novel potential mechanism underlying age-related bone loss.

Deadly H5N1 Outbreak Triggers Unprecedented Caspian Tern Die-Off in Washington and Spreads To Harbor Seals

A 2023 epidemiological study revealed that 56% of a large Caspian tern breeding colony at Rat Island, Washington, succumbed to an outbreak of highly pathogenic avian influenza. Following this event, no birds have successfully bred on the island, heightening concerns about the outbreak’s potential impact on an already declining Pacific coast population.

As part of the study, a team including Washington Department of Fish and Wildlife (WDFW) as well as Washington State University researchers also documented that the avian flu virus H5N1was transmitted to harbor seals for the first time in the northeastern Pacific.

While there has not been another large coastal wildlife outbreak of H5N1 since, researchers estimated that about 10–14% of the Caspian tern population in the Pacific flyway have been lost to H5N1 infections.

Could Data Be Stored in Plastic? Here’s How It Works

A new technique enables data storage in synthetic polymers, allowing direct bit access without full sequence decoding, significantly increasing storage density and stability, demonstrated by encoding a university address in ASCII within a polymer.

The need for data storage is growing, with many types of data requiring long-term preservation. Synthetic polymers present an efficient alternative to traditional storage media, as they can store information using less space and energy. However, conventional retrieval methods, like mass spectrometry, limit the length—and therefore the storage capacity—of individual polymer chains. Now, as reported in Angewandte Chemie, researchers have developed a new approach that overcomes this limitation, enabling direct access to specific data bits without having to read the entire chain.

Advantages of polymer storage over DNA.

Stanford Scientists Overturn Mendel’s Law With Shocking Cancer Discovery

A trio of research papers from Stanford Medicine researchers and their international collaborators transforms scientists’ understanding of how small DNA circles — until recently dismissed as inconsequential — are major drivers of many types of human cancers.

The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called ecDNA for extrachromosomal DNA, in nearly 15,000 human cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an anti-cancer therapy targeting the circles that is already in clinical trials.

The team, jointly known as eDyNAmiC, are a group of international experts led by professor of pathology Paul Mischel, MD. In 2022, Mischel and the eDyNAmiC team were awarded a $25 million grant from the Cancer Grand Challenges initiative to learn more about the circles. Cancer Grand Challenges, a research initiative co-founded by Cancer Research UK and the National Cancer Institute in the United States, supports a global community of interdisciplinary, world-class research teams to take on cancer’s toughest challenges.

Infection Aftershock: COVID-19’s Long-Term Impact on Your Heart

New research indicates that people who contracted COVID-19 early in the pandemic faced a significantly elevated risk of heart attack, stroke, and death for up to three years post-infection.

Those with severe cases saw nearly quadruple the risk, especially in individuals with A, B, or AB blood types, while blood type O was associated with lower risk. This finding highlights long-term cardiovascular threats for COVID-19 patients and suggests that severe cases may need to be considered as a new cardiovascular risk factor. However, further studies on more diverse populations and vaccinated individuals are needed to validate these results.

Long-term cardiovascular risks linked to COVID-19 infection.

NIH study demonstrates long-term benefits of weight-loss surgery in young people

Adolescents see a greater remission of type 2 diabetes compared to adults.

What

Young people with severe obesity who underwent weight-loss surgery at age 19 or younger continued to see sustained weight loss and resolution of common obesity-related comorbidities 10 years later, according to results from a large clinical study funded by the National Institutes of Health (NIH).

Novel magnetic therapy complements chemotherapy to enhance breast cancer treatment outcomes

Breast cancer is the leading cause of cancer-associated death for women worldwide. While chemotherapy is the mainstream treatment for breast cancer, more than 50% of women undergoing chemotherapy will experience at least one chemotherapy-related adverse side effect. Sometimes, the side effects could be so severe that patients need to terminate treatment early or doctors have to reduce the chemo dosage, and this could worsen their disease. Prolonged exposure to high doses of chemotherapeutic agents could also result in resistance to chemotherapy.

A team of researchers from the National University of Singapore (NUS) is pioneering a novel magnetic therapy — delivered using the OncoFTX System — that serves as an effective companion therapy to chemotherapy to enhance treatment outcome for breast cancer.

Our magnetic technology stimulates cellular oxygen respiration to produce energy. In certain cancers with elevated respiratory rates — such as breast tumors — the magnetic pulses cause the cancer cells to ‘hyperventilate’ and die. Fortunately, the healthy tissues near the cancer are able to tolerate the increased respiratory rate, without ill consequences. Therefore, the OncoFTX System is more selective for cancer than conventional chemotherapy or radiotherapy. Importantly, this therapy is localized, non-invasive and painless.

New medical procedure for treating irregular heart rhythm

The technology is designed to treat the condition atrial fibrillation, or irregular heart rhythm. This is in a way that carries a lower risk of complications and shorter anaesthesia time (when compared to traditional treatment).

The new technology took eighteen years to develop. In recent months, pulsed field ablation has been approved by the U.S. Food and Drug Administration (FDA) and the acceptance marks a milestone in heart treatment.

The process involves the use of microsecond-scale, high-voltage electrical fields to cause irreversible electroporation and destabilization of cell membranes, according to the New England Journal of Medicine.

Uncovering the effect of low-frequency static magnetic field on tendon-derived cells: from mechanosensing to tenogenesis

Magnetotherapy has been receiving increased attention as an attractive strategy for modulating cell physiology directly at the site of injury, thereby providing the medical community with a safe and non-invasive therapy.

Pesqueira, T., Costa-Almeida, R. & Gomes, M.E. Sci Rep 7, 10,948 (2017). https://doi.org/10.1038/s41598-017-11253-6

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