Lifeboat Foundation

Crispre cas 9.

A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience can overcome this barrier by studying multiple species to differentiate between species-specific and general mechanisms of neural circuit functioning. Targeted manipulation of neural circuits often depends on genetic dissection, and use of this technique has been restricted to only a few model species, limiting its application in comparative research. However, ongoing advances in genomics make genetic dissection attainable in a growing number of species. To demonstrate the potential of comparative gene editing approaches, we developed a viral-mediated CRISPR/Cas9 strategy that is predicted to target the oxytocin receptor (Oxtr) gene in 80 rodent species. This strategy specifically reduced OXTR levels in all evaluated species (n = 6) without causing gross neuronal toxicity. Thus, we show that CRISPR/Cas9-based tools can function in multiple species simultaneously. Thereby, we hope to encourage comparative gene editing and improve the translatability of neuroscientific research.

The development of comparative gene editing strategies improves the translatability of animal research.

A scientist claims he has increased his lifespan by 20 percent after living 93 days underwater.

Joseph Dituri, 55, a retired Naval officer, has been living inside a 100-square-foot pod at the bottom of the Atlantic Ocean for 93 days, researching how a pressurized environment impacts the human body.

Continue reading “Scientist living at the bottom of the Atlantic said he has de-aged” »

12 years of blood, sweat, and science went into success.

USC Dornsife researchers employ artificial intelligence to unveil the intricate world of DNA structure and chemistry, enabling unprecedented insights into gene regulation and disease.

Atom for the first time. Using a pioneering technique known as synchrotron X-ray scanning tunneling microscopy (SX-STM), the team was able to identify and characterize individual atoms, opening new possibilities in environmental, medical, and quantum research.

A team of scientists from Ohio University, Argonne National Laboratory, the University of Illinois-Chicago, and others, led by Ohio University Professor of Physics, and Argonne National Laboratory scientist, Saw Wai Hla, has taken the world’s first X-ray SIGNAL (or SIGNATURE) of just one atom. This groundbreaking achievement was funded by the U.S. Department of Energy, Office of Basic Energy Sciences, and could revolutionize the way scientists detect materials.

Researchers have for the first time characterized a unique molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in prevention of cancer.

The study, which is published June 2, 2023 in Science Advances, was led by Dr. Luke Clifton at the STFC ISIS Neutron and Muon Source (ISIS) in Oxfordshire, alongside co-lead Professor Gerhard Gröbner at the University of Umeå and partners at the European Spallation Source in Sweden. It is the most recent in a series of research collaborations by this team, investigating the cellular proteins responsible for apoptosis.

Apoptosis is essential for human life, and its disruption can cause cancerous cells to grow and not respond to cancer treatment. In healthy cells, it is regulated by two proteins with opposing roles known as Bax and Bcl-2.

Year 2022 face_with_colon_three

New way of altering DNA is used to engineer an “exciting”, experimental therapy for a 13-year-old girl.

Year 2022 o.o!!!

From ocean depths to mountain peaks, humans have littered the planet with tiny shards of plastic. We have even absorbed these microplastics into our bodies—with uncertain implications.

Images of plastic pollution have become familiar: a turtle suffocated by a shopping bag, water bottles washed up on beaches, or the monstrous “Great Pacific Garbage Patch” of floating detritus.

Continue reading “‘They’re everywhere’: microplastics in oceans, air and human body” »

On Monday, Apple is more than likely going to reveal its long-awaited augmented or mixed reality Reality Pro headset during the keynote of its annual WWDC developer conference in California. It’s an announcement that has been tipped or teased for years now, and reporting on the topic has suggested that at various times, the project has been subject to delays, internal skepticism and debate, technical challenges and more. Leaving anything within Apple’s sphere of influence aside, the world’s overall attitude toward AR and VR has shifted considerably — from optimism, to skepticism.

Part of that trajectory is just the natural progression of any major tech hype cycle, and you could easily argue that the time to make the most significant impact in any such cycle is after the spike of undue optimism and energy has subsided. But in the case of AR and VR, we’ve actually already seen some of the tech giants with the deepest pockets take their best shots and come up wanting — not for lack of trying, but because of limitations in terms of what’s possible even at the bleeding edge of available tech. Some of those limits might actually be endemic to AR and VR, too, because of variances in the human side of the equation required to make mixed reality magic happen.

The virtual elephant in the room is, of course, Meta. The name itself pretty much sums up the situation: Facebook founder Mark Zuckerberg read a bad book and decided that VR was the inevitable end state of human endeavor — the mobile moment he essentially missed out on, but even bigger and better. Zuckerberg grew enamored by his delusion, first acquiring crowdfunded VR darling Oculus, then eventually commandeering the sobriquet for a shared virtual universe from the dystopian predictions of a better book and renaming all of Facebook after it.