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Scientists Discover Unexpected Link Between Diet And Lung Cancer Risk

Most of us would probably think of smoking or air pollution when it comes to lung cancer risk, but researchers have discovered an intriguing link between the disease and the quality of our diets.

The researchers, from the University of Florida and the University of Kentucky, found that the molecule glycogen, which stores the simple sugar glucose, could potentially act as a driver of some types of lung cancer.

Glycogen was found at higher levels in human tissue samples of lung adenocarcinoma, the type responsible for 40 percent of lung cancers worldwide. In tests on mice, the team found that more glycogen helped lung cancers to grow faster, while taking the molecule away led to restricted tumor growth.

Which Biomarkers Are Associated With Cancer Cachexia?

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Scientists propose a targeted lysosomal dysfunction approach for glioblastoma treatment

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications on how the targeted suppression of lysosome function may lead to brain cancer therapy.

Glioblastoma is a type of brain cancer with a very poor prognosis of survival. Causes of are not known, and there is no method for preventing the cancer. Traditional treatment includes the drug temozolomide (TMZ). In many cases, TMZ kills glioblastoma cells, but a significant portion of patients show resistance to the drug.

Changes in the levels of metabolites— playing key roles in metabolic processes in living organisms—have been observed in TMZ-resistant glioblastoma cells, pointing to the importance of understanding and targeting metabolic pathways in the context of cancer therapy.

Cancer cells mimic Sherpa genes to survive low oxygen

Results of a study show convergent genetic adaptation under hypoxia (lack of oxygen) between populations living at high-altitude in the Himalayan region such as Tibetans and Sherpas, and the development of oxygen-starved cancer cells. The study was directed by Rodrigo Toledo, Head of the Vall d’Hebron Institute of Oncology’s (VHIO) Biomarkers and Clonal Dynamics Group and published in the journal Cancer Discovery.

Patients with cyanotic congenital heart disease (CCHD) are chronically hypoxic and have an estimated six-fold higher risk of developing pheochromocytoma and paraganglioma (PPGL), which are associated with (NETs) of the adrenal glands and/or paraganglia, respectively. These cancers can continue to grow and proliferate under chronic hypoxia.

“With this study, we aimed to achieve deeper insights into how tumors can survive, grow, and even metastasize under low oxygen conditions, known as hypoxia. Our findings reveal a broad convergence in in tumors that continue to develop and grow under hypoxia, and in high-altitude populations who thrive in such a challenging environment,” said Toledo, corresponding author of this present article.

Medical Breakthrough: Scientists Use Patient’s Own Fat Cells to Reverse Type 1 Diabetes

A new hope for diabetes patients: reprogrammed stem cells achieve insulin independence.

In a pioneering medical breakthrough, scientists in China have successfully reversed type 1 diabetes in a patient by reprogramming her own fat cells into insulin-producing pancreatic cells. This revolutionary approach offers a promising alternative to current diabetes treatments and could pave the way for a potential cure for millions of people affected by this chronic autoimmune disease. The patient involved in the study remains free from insulin injections more than a year after receiving the experimental treatment, highlighting the potential of stem cell therapy as a game-changer in diabetes care.

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