Lifeboat Foundation

Language impairment is comorbid in most children with Autism Spectrum Disorder (ASD) but its neural basis is poorly understood. Using structural magnetic resonance imaging (MRI), the present study provides the whole-brain comparison of both volume-and surface-based characteristics between groups of children with and without ASD and investigates the relationships between these characteristics in language-related areas and the language abilities of children with ASD measured with standardized tools. A total of 36 school-aged children participated in the study: 18 children with ASD and 18 age-and sex-matched typically developing controls. The results revealed that multiple regions differed between groups of children in gray matter volume, gray matter thickness, gyrification, and cortical complexity (fractal dimension).

Optical imaging and metrology techniques are key tools for research rooted in biology, medicine and nanotechnology. While these techniques have recently become increasingly advanced, the resolutions they achieve are still significantly lower than those attained by methods using focused beams of electrons, such as atomic-scale transmission electron spectroscopy and cryo-electron tomography.

Researchers at University of Southampton and Nanyang Technological University have recently introduced a non-invasive approach for optical measurements with atomic-scale resolution. Their proposed approach, outlined in Nature Materials, could open exciting new possibilities for research in a variety of fields, allowing scientists to characterize systems or phenomena at the scale of a fraction of a billionth of a meter.

“Since the nineteen century, improvements of spatial resolution of microscopy has been a major trend in science that has been marked with at least seven Nobel Prizes,” Nicolay I. Zheludev, one of the researchers who carried out the study told Phys.org. “Our dream was to develop technology that can detect atomic scale events with light, and we have been working on this for the last three years.”

A machine learning-based method developed by a Mount Sinai research team allows medical facilities to forecast the mortality risk for certain cardiac surgery patients. The new method is the first institution-specific model for determining the risk of a cardiac patient before surgery and was developed using vast amounts of Electronic Health Data (EHR).

Comparing the data-driven approach to the current population-derived models reveals a considerable performance improvement.

Summary: Researchers have developed an artificial electronic skin (e-skin) capable of converting sensory inputs into electrical signals that the brain can interpret. This skin-like material incorporates soft integrated circuits and boasts a variety of sensory abilities, including temperature and pressure detection.

This advance could facilitate the creation of prosthetic limbs with sensory feedback or advanced medical devices. The e-skin operates at a low voltage and can endure continuous stretching without losing its electrical properties.

In my work, I build instruments to study and control the quantum properties of small things like electrons. In the same way that electrons have mass and charge, they also have a quantum property called spin. Spin defines how the electrons interact with a magnetic field, in the same way that charge defines how electrons interact with an electric field. The quantum experiments I have been building since graduate school, and now in my own lab, aim to apply tailored magnetic fields to change the spins of particular electrons.

Research has demonstrated that many physiological processes are influenced by weak magnetic fields. These processes include stem cell development and maturation, cell proliferation rates, genetic material repair, and countless others. These physiological responses to magnetic fields are consistent with chemical reactions that depend on the spin of particular electrons within molecules. Applying a weak magnetic field to change electron spins can thus effectively control a chemical reaction’s final products, with important physiological consequences.

Currently, a lack of understanding of how such processes work at the nanoscale level prevents researchers from determining exactly what strength and frequency of magnetic fields cause specific chemical reactions in cells. Current cell phone, wearable, and miniaturization technologies are already sufficient to produce tailored, weak magnetic fields that change physiology, both for good and for bad. The missing piece of the puzzle is, hence, a “deterministic codebook” of how to map quantum causes to physiological outcomes.

A research group led by Professor Minoru Osada (he, him) and postdoctoral researcher Yue Shi (she, her) at the Institute for Future Materials and Systems (IMaSS), Nagoya University in Japan, has developed a new technology to fabricate nanosheets, thin films of two-dimensional materials a couple of nanometers thick, in about one minute.

This technology enables the formation of high-quality, large nanosheet films with a single click without the need for specialized knowledge or technology. Their findings are expected to contribute to developing the industrial manufacturing process for various types of nanosheet devices. The study was published in ACS Applied Materials & Interfaces.

Nanosheets have a thickness that is measured in nanometers. Nanometers are so thin that the sheets cannot be seen from the side with the naked eye. They have potential uses in several different fields, including electronics, catalysis, energy storage, and biomedicine. Those made from graphene and inorganic nanosheets are being tested for use in a range of devices, from solar cells to sensors and batteries, because they have electrical, transparency, and heat-resistance functions different from those of conventional bulk materials.

Researchers at the University of Cologne have discovered a protein complex, called DREAM, that inhibits DNA repair mechanisms in human, mouse, and nematode cells, thereby contributing to aging and disease. They successfully suppressed the DREAM complex with a pharmaceutical agent, boosting the cells’ resilience to DNA damage, and suggesting potential new treatments for aging and cancer, although further research is needed.

Researchers at the University of Cologne have found that a protein complex impedes the repair of genomic damage in human cells, mice, and the nematode Caenorhabditis elegans. Furthermore, they were able to successfully obstruct this complex with a pharmaceutical agent for the first time.

When we suppress the so-called DREAM complex in body cells, various repair mechanisms kick in, making these cells extremely resilient towards all kinds of DNA.

Year 2022

Experiments such as this one cannot be funded with federal research dollars, though they break no U.S. laws. The work was conducted in China, not because it was illegal in the United States, the researchers said, but because the monkey embryos, which are difficult to procure and expensive, were available there. The experiment used a total of 150 embryos, which were obtained without harming the monkeys, “just like in the IVF procedure,” Tan said.

But such experiments, which combine human cells with those of animals, are nevertheless controversial. This work, and other work by Izpisua Belmonte, has moved so rapidly, bioethicists have had trouble keeping up.

Continue reading “International team creates first chimeric human-monkey embryos” »

They identified a new type of stem cell, which enables deer to regenerate their antlers year after year.

When transplanted into mice, it took just 45 days for them to grow antler-like bumps containing cartilage and bone.

This early research could potentially give us a better way to repair skeletal injuries — and maybe even help us to regrow our own limbs one day: https://www.freethink.com/science/deer-antlers-regeneration.

Continue reading “Scientists in China have grown deer antlers on mice using stem cells:” »