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Category: biotech/medical – Page 633

Newly discovered protein prevents DNA triplication

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent. This means that, millions of times a day, a biochemical wonder takes place in the body: the copying of the DNA molecule. It is a high-precision job carried out by specific proteins and includes systems to protect against potential errors that could lead to diseases such as cancer.

One of these anti-failure systems has just been discovered by researchers in the DNA Replication Group at the Spanish National Cancer Research Centre (CNIO), led by Juan Méndez. It is based on a protein that ensures that DNA is copied only once, as it should be, and not twice or more.

The work is published in The EMBO Journal.

Using generative AI to improve software testing

Generative AI is getting plenty of attention for its ability to create text and images. But those media represent only a fraction of the data that proliferate in our society today. Data are generated every time a patient goes through a medical system, a storm impacts a flight, or a person interacts with a software application.

Using generative AI to create realistic around those scenarios can help organizations more effectively treat patients, reroute planes, or improve software platforms—especially in scenarios where real-world data are limited or sensitive.

For the last three years, the MIT spinout DataCebo has offered a generative software system called the Synthetic Data Vault to help organizations create synthetic data to do things like test software applications and train machine learning models.

Shape-shifting ultrasound stickers detect post-surgical complications

Researchers led by Northwestern University and Washington University School of Medicine in St. Louis have developed a new, first-of-its-kind sticker that enables clinicians to monitor the health of patients’ organs and deep tissues with a simple ultrasound device.

When attached to an organ, the soft, tiny sticker changes in shape in response to the body’s changing pH levels, which can serve as an sign for post-surgery complications such as anastomotic leaks. Clinicians then can view these shape changes in real time through ultrasound imaging.

Currently, no existing methods can reliably and non-invasively detect anastomotic leaks—a life-threatening condition that occurs when gastrointestinal fluids escape the digestive system. By revealing the leakage of these fluids with high sensitivity and , the non-invasive sticker can enable earlier interventions than previously possible. Then, when the patient has fully recovered, the biocompatible, bioresorbable sticker simply dissolves away—bypassing the need for surgical extraction.

The Flu’s Hidden Weakness: New Antibodies Target “Dark Side” of Virus Protein

Scientists at the National Institutes of Health have discovered antibodies that attack a difficult-to-detect area of the influenza virus, shedding light on the relatively unexplored “dark side” of the neuraminidase (NA) protein head. The antibodies target a region of the NA protein that is common among many influenza viruses, including H3N2 subtype viruses, and could be a new target for countermeasures. The research, led by scientists at the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center, part of NIH, was recently published in the journal Immunity.

Influenza, or flu, sickens millions of people across the globe each year and can lead to severe illness and death. While vaccination against influenza reduces the burden of the disease, updated vaccines are needed each season to provide protection against the many strains and subtypes of the rapidly evolving virus. Vaccines that provide protection against a broad range of influenza viruses could prevent outbreaks of new and reemerging flu viruses without the need for yearly vaccine reformulation or vaccinations.

Michigan lawmaker introduces bill requiring state health plans to cover cutting-edge cancer treatments

A Michigan state senator introduced a bill that would require health insurance companies in the state to cover cutting-edge cancer treatments, even if they are not categorized as a “cancer drug.”

State Sen. Jeff Irwin (D-Mich.) announced his new bill in a video on X, formerly Twitter, on Tuesday. The legislation would build on an existing law that already says cancer drugs must be covered by health insurance companies.

Blocking Key Potein may Halt Progression of Alzheimer’s disease

Researchers at the University of Colorado Anschutz Medical Campus have found that inhibiting a key protein can stop the destruction of synapses and dendritic spines commonly seen in Alzheimer’s disease.

The study, whose first author is Tyler Martinez, a student in the Pharmacology and Molecular Medicine PhD program at the University of Colorado School of Medicine, was published recently in the journal eNeuro.

The researchers, using rodent neurons, found that targeting a protein called Mdm2 with an experimental cancer drug known as nutlin, stopped neurotoxic amyloid-b peptides that accumulate in Alzheimer’s disease (AD) from overly pruning synapses.

Long-term Analysis reveals SARS-CoV-2 Infection and Vaccine-induced Antibody Responses are Long-Lasting

A long-term analysis conducted by leading microbiologists at the Icahn School of Medicine at Mount Sinai reveals that antibody responses induced by COVID-19 vaccines are long-lasting. The study results, published online in the journal Immunity challenge the idea that mRNA-based vaccine immunity wanes quickly.

The emergence of SARS-CoV-2, the virus that causes COVID-19, in late 2019 sparked the global pandemic that is now in its fifth year. Vaccines that were developed at record speed have saved millions of lives. However, the emergence of SARS-CoV-2 variants and waning immunity have decreased the effectiveness of the vaccines against symptomatic disease. The common perception now is that mRNA-based vaccine-induced immunity wanes quickly.

However, this assumption is largely based on data from short-term studies that include a very limited number of data points following peak responses.

3D-printed skin closes wounds and contains hair follicle precursors

Science: In future maybe wounds be cured and closed in seconds by 3D printing regeneration.

Fat tissue holds the key to 3D printing layered living skin and potentially hair follicles, according to researchers who recently harnessed fat cells and supporting structures from clinically procured human tissue to precisely correct injuries in rats. The advancement could have implications for reconstructive facial surgery and even hair growth treatments for humans.

The team’s findings were published March 1 in Bioactive Materials. The U.S. Patent and Trademark Office granted the team a patent in February for the bioprinting technology it developed and used in this study.

“Reconstructive surgery to correct trauma to the face or head from injury or disease is usually imperfect, resulting in scarring or permanent hair loss,” said Ibrahim T. Ozbolat, professor of engineering science and mechanics, of and of neurosurgery at Penn State, who led the that conducted the work.

Dancing cells show how the brain awakens from anesthesia

According to a Mayo Clinic study published in Nature Neuroscience, the cells that act as the central nervous system’s first line of defense against harm also play a role in helping the brain awaken from anesthesia. This discovery could help pave the way for innovative methods that address post-anesthesia complications.

When coming out of anesthesia, more than one-third of patients can experience either extreme drowsiness or hyperactivity, a side effect called delirium. Mayo researchers found that special immune cells in the brain called microglia can act to shield neurons from the aftereffects of anesthesia to awaken the brain.

“This is the first time we’ve seen microglia enhance and boost by physically engaging the brain circuits,” says Mayo Clinic neuroscientist Long-Jun Wu, senior author of the study.