Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 633

Stem cells, lab-grown meat, and potential new medical treatments, with Mark Kotter

Our guest in this episode is Dr. Mark Kotter. Mark is a neurosurgeon, stem cell biologist, and founder or co-founder of three biotech start-up companies that have collectively raised hundreds of millions of pounds: bit.bio, clock.bio, and Meatable.

In addition, Mark still conducts neurosurgeries on patients weekly at the University of Cambridge.

We talk to Mark about all his companies, but we start by discussing Meatable, one of the leading companies in the cultured meat sector. This is an area of technology which should have a far greater impact than most people are aware of, and it’s an area we haven’t covered before in the podcast.

Selected follow-ups:

• Dr Mark Kotter at the University of Cambridge (https://www.stemcells.cam.ac.uk/peopl…)
• Meatable (https://meatable.com/)
• bit.bio (https://www.bit.bio/)
• clock.bio (https://clock.bio/)
• After 25 years of hype, embryonic stem cells are still waiting for their moment (https://www.technologyreview.com/2023…) — Article in MIT Technology Review.
• The Nobel Prize in Physiology or Medicine 2012 (https://www.nobelprize.org/prizes/med…)
• Moo’s Law: An Investor’s Guide to the New Agrarian Revolution (https://www.harriman-house.com/mooslaw) — book by Jim Mellon.
• What is the climate impact of eating meat and dairy? (https://interactive.carbonbrief.org/w…)
• Guidance for businesses on cell-cultivated products and the authorisation process (https://www.food.gov.uk/business-guid…)
• Wild mammals make up only a few percent of the world’s mammals (https://ourworldindata.org/wild-mamma…) — Our World In Data.
• BlueRock Therapeutics (https://www.bluerocktx.com/)
• Therapies under development at bit.bio (https://www.bit.bio/therapeutics2023)
• Stem Cell Gene Therapy Shows Promise in ALS Trial (https://www.technologynetworks.com/ne…) — from Cedars-Sinai Medical Center.

Music: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration.

Continue reading “Stem cells, lab-grown meat, and potential new medical treatments, with Mark Kotter” | >

How Ancient Viruses may be Connected to Human Psychiatric Disorders

The human genome is massive, and it contains many highly repetitive sequences that confounded researchers for years. Many of these repeats were simply written off as junk DNA that had no function. However, new research is revealing that many of these regions are much more important than we thought. Some of the repetitive portions of the genome are known to be human endogenous retroviruses (HERVs). These sequences originated from viruses that infected human germ cells millions of years ago and affected our evolution. About eight percent of our genome is thought to be made up of HERVs. These HERVs have also been associated with a variety of psychiatric disorders, although the connection is unclear.

A new study reported in Nature Communications has suggested that HERVs are making a significant but unappreciated contribution to the development of psychiatric disorders, and that they may help explain a genetic component of these disorders that is thought to exist but has not yet been identified.

Tyler Goldstein’s Theory of Everyone: Sentient Singularity

Dive into the intriguing world of Sentient Singularity Theory, a groundbreaking framework that seeks to explain the interconnected nature of consciousness, cosmology, and metaphysics. Created by Tyler Goldstein, this theory posits that every particle and atom in the universe is a conscious participant in the grand dance of existence. Discover how the universe is viewed not just as a mechanical construct but as a living organism, where space, time, matter, and force emerge from the interactions of sentient beings. Join us as we explore the Four Primary Perspectives, the concept of infinite-oneness, and the idea of a self-simulating universe. Through this journey, we’ll challenge conventional understandings and delve deep into the philosophical and metaphysical implications of a Theory of Everyone. Don’t miss this thought-provoking exploration into the very fabric of reality.

#SentientSingularityTheory #Consciousness #Metaphysics #Cosmology #TheoryOfEverything.

Become a member of this channel to enjoy benefits:
/ @artificiallyaware

New study shows urolithin A can improve treatment of Alzheimer’s

The research team found that long-term urolithin A treatment in mice significantly improved their learning, memory and olfactory function. The treatment also reduced amyloid beta (Aβ) and tau pathologies and improved cellular lysosomal function [1].

The researchers’ findings also suggest that urolithin A is as effective as NAD in promoting mitophagy, positioning it as a potential therapeutic agent for Alzheimer’s disease.

“Our study on mouse models with AD shows that urolithin A, which is a naturally occurring substance in pomegranates, can alleviate memory problems and other consequences of dementia,” says Bohr. “Even though the study was conducted on mouse models, the prospects are positive. So far, research has shown promising results for the substance in the muscles, and clinical trials on humans are being planned [3].”

Can this Thumb Test tell if you are at increased Risk of a Hidden Aortic Aneurysm?

All the parts of our bodies share an inherent connectivity. This goes much further than “the foot bone’s connected to the … leg bone.” For instance, both hands and feet are connected to a constantly flowing bloodstream, and a nerve network that makes their muscles kick.

So what about the connection recently proposed by some news outlets regarding a simple test involving your palm and thumb? Could it really help diagnose a silent, yet potentially serious problem?

An aneurysm is what we’re referring to here. This is a ballooned segment of an artery—the vessels that supply oxygenated blood to your body tissues. Aneurysms may cause no problems, but if they grow larger, they can weaken, burst and bleed. This is bad enough in most arteries, but imagine if the artery involved were the biggest in your body?

Training Transhumanists at Oxford University

Those who know Oxford University for its literary luminaries might be surprised to learn that some of the most important reflections on emerging technologies come from its hallowed halls. While the leading tech innovators in Silicon Valley capture imaginations with their bold visions of future singularities, mind-machine melding, and digital immortality by 2045, they rarely engage as deeply with the philosophical issues surrounding such developments as their like-minded scholars over the pond. This essay will briefly highlight some of the key contributions of Oxford University’s professors Nick Bostrom, Anders Sandberg, and Julian Savulescu to the transhumanist movement. It will also show how this movement’s focus on radical autonomy in biotechnical enhancements shapes the wider global bioethical conversation.

As the lead author of the Transhumanist FAQ, Bostrom provides the closest the movement has to an institutional catechism. He is, in a sense, the Ratzinger of Transhumanism. The first paragraph of the seminal text emphasizes the evolutionary vision of his school. Transhumanism’s incessant pursuit of radical technological transformation is “based on the premise that the human species in its current form does not represent the end of our development but rather a comparatively early phase.” Current humans are but one intriguing yet greatly improvable iteration of human existence. Think of the first iPhone and how unattractive 2007’s most cutting-edge technology is in 2024.

In particular, transhumanists encourage radical physical, cognitive, mood, moral, and lifespan enhancements. The movement seeks to defeat humanity’s perennial enemies of aging, sickness, suffering, and death. Bostrom recognizes that he is facing the same foes as Christianity and other traditional religions. Yet he is confident that Transhumanism, through science and technology, will be far more successful than outdated superstitions. Biotechnological advances are more reliable for this worldly benefit than religion’s promises of some mysterious next life. Transhumanists claim no need for “supernatural powers or divine intervention” in their avowedly “naturalistic outlook” since they rely instead on “rational thinking and empiricism” and “continued scientific, technological, economic, and human development.” Nonetheless, Bostrom and his companions recognize that not all technology is created equal.

/* */