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Eukaryotes generate the energy for survival through cellular respiration in mitochondria by a process known as the oxidative phosphorylation. In this process, nutrients and oxygen are converted into a chemical form of energy: ATP. This is achieved with a proton gradient built up by the electron transport chain inside mitochondria.

Continue reading “Exploring a massive supercomplex in mitochondria comprising all four respiratory complexes” »

Follow our step-by-step video guide for growing cerebral organoids, or brain organoids, from human pluripotent stem cells (hPSCs). We’ll walk you through embryoid body formation, induction, expansion, and organoid maturation.

0:35 — Embryoid Body Formation.
2:57 — Induction.
4:07 — Expansion.
6:42 — Organoid Maturation.

Continue reading “How to Grow Cerebral Organoids from Human Pluripotent Stem Cells” »

Ambassador Dr. John-Arne Røttingen, MD, Ph.D. (https://www.bsg.ox.ac.uk/people/john-arne-rottingen) is Ambassador for Global Health, at the Ministry of Foreign Affairs, Norway, and a Visiting Fellow of Practice, at the Blavatnik School of Government, Oxford University.

Ambassador Dr. Røttingen has previously served as the Chief Executive of the Research Council of Norway; the founding Chief Executive Officer of the Coalition for Epidemic Preparedness Innovations (CEPI); Executive Director of Infection Control and Environmental Health at the Norwegian Institute of Public Health; founding Chief Executive of the Norwegian Knowledge Centre for the Health Services; Professor of Health Policy at the Department of Health Management and Health Economics, Institute of Health and Society, University of Oslo; and Adjunct Professor at the Department of Global Health and Population, Harvard T.H. Chan School of Public Health.

Continue reading “Dr. John-Arne Røttingen, MD, PhD — Ambassador for Global Health, Ministry of Foreign Affairs, Norway” »

Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.

That newly found strategy used by tumors that have spread—and are consequently more deadly—may help explain why sometimes promising immunotherapies designed to help the immune system kill cancer don’t, says Kebin Liu, Ph.D., cancer immunologist in the Department of Biochemistry and Molecular Biology at the Medical College of Georgia.

It also may mean an additional therapeutic maneuver is needed to stop some tumors, which often are diagnosed after they have spread, says Liu, corresponding author of the study in the journal Cancer Cell.

In the current edition of The Lancet Neurology, researchers of the Human Brain Project (HBP) present the novel clinical uses of advanced brain modeling methods. Computational brain modeling techniques that integrate the measured data of a patient have been developed by researchers at AMU Marseille as part of the HBP. The models can be used as predictive tools to virtually test clinical hypotheses and strategies.

To create personalized brain models, the researchers use a simulation technology called The Virtual Brain (TVB), which HBP scientist Viktor Jirsa has developed together with collaborators. For each patient, the computational models are created from data of the individually measured anatomy, structural connectivity and brain dynamics.

The approach has been first applied in epilepsy, and a major clinical trial is currently ongoing. The TVB technology enables clinicians to simulate the spread of abnormal activity during epileptic seizures in a patient’s brain, helping them to better identify the target areas. In January, the team had presented the detailed methodology of the epilepsy work on the cover of Science Translational Medicine.

In the intensive care unit (ICU), critically ill patients are cared for by a multidisciplinary care team. Compassionate and caring behaviors on the part of the care team result in better outcomes for patients and their families, and care providers entering the demanding field of medicine because they wish to help people and relieve suffering. However, studies have demonstrated deficiencies in delivering compassionate health care. Evidence suggests that physicians may miss up to 90% of opportunities to respond to patients with compassion.

To determine what factors drive and enhance compassionate care behaviors in the ICU setting and which factors drain and negate caring attitudes and behaviors, Shahla Siddiqui, MD, MSc, FCCM, and a colleague conducted an observational, qualitative study of an international panel of intensive and critical care providers. The researcher-clinicians report in PLOS ONE that while ICU physicians and nurses feel a deep moral imperative to deliver the highest level of compassionate care, pressures of capacity strain, lack of staff, lack of compassionate skills training and a heavy emphasis on electronic health record maintenance present significant hurdles to achieving that goal.

“Studies done on physician compassion from a patient perspective emphasize listening and awareness of the patient’s emotional state, which not only builds trust within the patient-physician relationship but also enhances resilience amongst the care team and prevents burnout,” said Siddiqui, an anesthesiologist at BIDMC. “Our aim was to describe compassionate behaviors in the ICU, study the factors that enhance and those that drain such behaviors with an aim to enable recommendations for practice and training.”

In 2015, European countries formulated the Sustainable Development Goals (SDG), which aimed to end TB by 2030. However, in September 2018, global leaders at the first United Nations (UN) General Assembly High-Level Meeting on the Fight Against TB agreed on an ambitious target of eradicating TB by 2022. They strategized that increased access to TB treatment and preventive measures would help achieve their goal quickly. Another measure adopted to progress the TB eradication goal was increasing the funds related to TB research and services.

An uneven progress regarding TB eradication by 2030 was observed in some European regions by the World Health Organization (WHO). Although the majority of Western European countries were on track for TB elimination, Eastern European and Central Asian countries reported a high number of incidences of drug-resistant (DR) TB.

In the European Union/European Economic Area (EU/EEA), TB prevalence is low. Based on the TB surveillance conducted in Europe, out of 30 countries, 24 reported less than 10 TB cases per 100,000 population in 2021. These countries have been encouraged to maintain this low rate and attain the pre-elimination phase of less than 10 TB cases per million population per year. A recent Eurosurveillance journal editorial discussed the progress in the EU/EEA, between 2018 and 2021, towards achieving the 2030 targets for TB elimination.

Summary: Using a new technology called The Virtual Brain, researchers are able to create personalized computerized brain models of individual patients based on their anatomy, structural connectivity, and brain dynamics.

Source: Human Brain Project.

In the current edition of The Lancet Neurology, researchers of the Human Brain Project (HBP) present the novel clinical uses of advanced brain modeling methods.

“People study cells in the context of their biology and biochemistry, but cells are also simply physical objects you can touch and feel,” Guo says. “Just like when we construct a house, we use different materials to have different properties. A similar rule must apply to cells when forming tissues and organs. But really, not much is known about this process.”

His work in cell mechanics led him to MIT, where he recently received tenure and is the Class of ’54 Career Development Associate Professor in the Department of Mechanical Engineering.

At MIT, Guo and his students are developing tools to carefully poke and prod cells, and observe how their physical form influences the growth of a tissue, organism, or disease such as cancer. His research bridges multiple fields, including cell biology, physics, and mechanical engineering, and he is working to apply the insights from cell mechanics to engineer materials for biomedical applications, such as therapies to halt the growth and spread of diseased and cancerous cells.