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Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans. The study, to be published March 17 in the Journal of Experimental Medicine, uses a new, highly versatile form of CRISPR-based genome editing with the potential to correct a wide variety of disease-causing genetic mutations.

Researchers have previously used genome editing to restore the vision of mice with genetic diseases, such as Leber congenital amaurosis, that affect the retinal pigment epithelium, a layer of non-neuronal cells in the eye that supports the light-sensing rod and cone photoreceptor cells. However, most inherited forms of blindness, including retinitis pigmentosa, are caused by genetic defects in the neural photoreceptors themselves.

“The ability to edit the genome of neural retinal cells, particularly unhealthy or dying photoreceptors, would provide much more convincing evidence for the potential applications of these genome-editing tools in treating diseases such as retinitis pigmentosa,” says Kai Yao, a professor at the Wuhan University of Science and Technology.

Northwestern Medicine scientists have uncovered a mechanism by which exercise activates metabolic benefits in the body, according to a new study published in Cell Metabolism.

It’s well known that exercise elicits many health benefits. However, how this is accomplished is not yet well understood. During exercise, autophagy, the body’s cellular recycling system that allows old or damaged cellular structures to be broken down, is activated in both contracting muscles and various non-contracting organs, such as the liver.

In the study, investigators performed proteomic analyses on the blood of mice before and after exercise. They identified a protein secreted from contracting muscle, FN1, which significantly increased in the plasma and serum of mice after exercise.

Even if you’re in remission or you show no evidence of disease, you may still have fears that cancer may return. We spoke with our social work counselors to learn more about fear of recurrence and get advice on how to manage it.

Superconducting at 69F!
Advanced superconducting materials at room temperature will bring about a paradigm shift in human technology and help us make great advances in energy, medicine, electronics and space explorations.
The Terran Space Academy walks you through the importance of the latest discovery, the details behind their research, and the space technologies it will immediately impact.
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Continue reading “Superconducting Breakthrough! This REALLY Changes Everything!” »

Intracerebral hemorrhage, and bleeding into the brain tissue, is a devastating neurological condition affecting millions of people annually. It has a high mortality rate, while survivors are affected by long-term neurological deficits. No medication has been found to support brain recovery following hemorrhage.

In an international collaboration, researchers from the Brain Repair laboratory, University of Helsinki, together with their Taiwanese colleagues investigated whether a protein called cerebral dopamine neurotrophic factor (CDNF) has potential as a treatment for brain hemorrhage.

Researchers suggest that cerebral dopamine neurotrophic factor, a protein being currently tested for Parkinson’s disease treatment, also has therapeutic effects and enhances immune cell’s response after brain hemorrhage.

HUMANS in the next 100 years could be part-machine, part-flesh creatures with brain chips and bionic limbs and organs in a vision of “cyborgs” once described by Elon Musk.

Men and women born around 2100 could live in a world very different to ours as humans may be totally connected to the internet and meshed together with artificial intelligence.

Mobile phones would no longer be needed — as everything you now do with your smartphone will now be done with a chip in your brain.

In a recent review published in the International Journal of Molecular Sciences, researchers in Canada investigate the impact of intestinal microbiota dysbiosis on atherosclerotic cardiovascular disease (ASCVD) incidence.

Study: Role of the Gut Microbiome in the Development of Atherosclerotic Cardiovascular Disease. Image Credit: ART-ur / Shutterstock.com

Summary: Text-to-image generation deep learning models like OpenAI’s DALL-E 2 can be a promising new tool for image augmentation, generation, and manipulation in a healthcare setting.

Source: JMIR Publications

A new paper published in the Journal of Medical Internet Research describes how generative models such as DALL-E 2, a novel deep learning model for text-to-image generation, could represent a promising future tool for image generation, augmentation, and manipulation in health care.

“It’s poor for that particular cell, but it protects the whole colony of bacteria so that virus doesn’t spread through it,” said Jackson.

CRISPR vs. cancer: The newly published papers detail the structure and function of Cas12a2, but more research is needed to determine how we might be able to harness this system for our benefit.

Continue reading “New killer CRISPR system is unlike any scientists have seen” »