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The fountain of youth is … a T cell?

“If we give it to aged mice, they rejuvenate. If we give it to young mice, they age slower. No other therapy right now can do this.”


The fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along.

Cold Spring Harbor Laboratory (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right set of genetic modifications, these white blood cells can attack another group of cells known as senescent cells. These cells are thought to be responsible for many of the diseases we grapple with later in life.

Senescent cells are those that stop replicating. As we age, they build up in our bodies, resulting in harmful inflammation. While several drugs currently exist that can eliminate these cells, many must be taken repeatedly over time.

Researchers develop nanofiber-based drug delivery system for skin cancer

Treating complex diseases such as skin cancer often requires simultaneous administration of multiple anticancer drugs. The delivery of such life-saving therapeutic drugs has evolved with the rise of nanotechnology-based drug carriers. Nanoplatforms offer numerous advantages, including increased bioavailability, lowered dosages, and improved biodistribution.

Now a team of researchers, led by Professor Myoung-Hwan Park from Sahmyook University in South Korea, has developed a light-responsive nanofiber-based novel (DDS) targeting skin cancer. The DDS was studied in a detailed manner, beginning with its synthesis and characterization to its biocompatibility, drug release profile, and efficacy against skin cancer. These research findings are published in the Journal of Drug Delivery Science and Technology.

Explaining the motivation behind the present research, Dr. Park states, “Conventional drugs can be efficiently delivered in a controlled manner through nano-engineered platforms, and such an approach increases the overall effectiveness of the treatment. This approach improves outcomes in cancer drug therapy by ensuring precise delivery at optimal dosages.”

Your Body Has Its Own Built-In Ozempic

This is good info but I’d like to do it naturally. I wonder if healing my gut biome with pro and prebiotics can help. There’s been psychiatric side effects with ozempic in a few cases. There’s often some kind of side effect when not natural but some people could benefit if monitored by a doctor.


Popular weight-loss and diabetes drugs, such as Ozempic and Wegovy, target metabolic pathways that gut microbes and food molecules already play a key role in regulating.

By Christopher Damman & The Conversation US

Innovative silicon nanochip can reprogram biological tissue in living body

Year 2021 Biocomputing is the future for the biological singularity because we could control all inputs and outputs of our bodies even evolve them eventually.


A silicon device that can change skin tissue into blood vessels and nerve cells has advanced from prototype to standardized fabrication, meaning it can now be made in a consistent, reproducible way. As reported in Nature Protocols, this work, developed by researchers at the Indiana University School of Medicine, takes the device one step closer to potential use as a treatment for people with a variety of health concerns.

The technology, called tissue nanotransfection, is a non-invasive nanochip device that can reprogram tissue function by applying a harmless electric spark to deliver specific genes in a fraction of a second. In laboratory studies, the device successfully converted into to repair a badly injured leg. The technology is currently being used to reprogram tissue for different kinds of therapies, such as repairing caused by stroke or preventing and reversing nerve damage caused by diabetes.

“This report on how to exactly produce these tissue nanotransfection chips will enable other researchers to participate in this new development in ,” said Chandan Sen, director of the Indiana Center for Regenerative Medicine and Engineering, associate vice president for research and Distinguished Professor at the IU School of Medicine.

Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy

Year 2023 Super tcells found in people that defeated cancer face_with_colon_three Basically tcells naturally eat cancer this therapy could lead to boosting the percentage of success rates in battling cancer.


Detailed characterization of the recognition and activation characteristics of T cells from successful therapy against melanoma unveils that individual T cells recognize multiple tumor-associated antigens simultaneously; elicitation or engineering of such “multipronged” T cells may be an effective means of enhancing the efficacy of T cell cancer therapy.

Researchers uncover molecular mechanisms behind effects of MXene nanoparticles on muscle regeneration

Tissue engineering, which involves the use of grafts or scaffolds to aid cell regeneration, is emerging as a key medical practice for treating volumetric muscle loss (VML), a condition where a significant amount of muscle tissue is lost beyond the body’s natural regenerative capacity. To improve surgical outcomes, traditional muscle grafts are giving way to artificial scaffold materials, with MXene nanoparticles (NPs) standing out as a promising option.

MXene NPs are 2D materials primarily composed of transition-metal carbides and nitride. They are highly electrically conductive, can accommodate a wide range of functional groups, and have stacked structures that promote cell interactions and growth. While there have been practical demonstrations in the laboratory showcasing their ability to promote the reconstruction of skeletal muscles, the specific mechanism by which they do so remains unclear.

To address this gap, Associate Professor Yun Hak Kim from the Department of Anatomy and Department of Biomedical Informatics, alongside Professors Suck Won Hong, and Dong-Wook Han from the Department of Cogno-Mechatronics Engineering at Pusan National University developed nanofibrous matrices containing MXene NPs as scaffolds. They used DNA sequencing to reveal the genes and biological pathways activated by MXene NPs to aid in muscle regeneration.

ITMO Researchers Develop Alternative Liquid-Based THz Radiation Source

Polar liquids, such as water, are powerful absorbents of electromagnetic waves in the terahertz range. For that reason, they were never considered as potential THz radiation sources. Last year, researchers from ITMO University and the University of Rochester proved that liquid-based radiation sources can be no less effective than traditional ones. In their new study, the staff of ITMO University’s Laboratory of Femtosecond Optics and Femtotechnologies present their research on the generation of THz radiation in liquid jets of various kinds. In the future, these findings can be used to create new alternative sources of THz radiation. The research was published in Optics Express.

Terahertz technologies: spectroscopy, security, biomedicine, and non-destructive diagnostics

Terahertz radiation is a type of electromagnetic radiation located within the frequency spectrum between infrared and radio. It passes well through a variety of materials, such as wood, plastic, and ceramics.

Nanoparticle spray reduces risk of airborne bacterial infections caused by air filtration systems

A novel nanoparticle spray coating process has been shown to all but eliminate the growth of some of the world’s most dangerous bacteria in air filtration systems, significantly reducing the risk of airborne bacterial and viral infections.

That’s the principal finding of a study, led by researchers from IMDEA Materials Institute in collaboration with scientists from the Networking Biomedical Research Center in Respiratory Diseases (CIBERES) and Rey Juan Carlos University (URJC) in Madrid, Spain. The study was published in Materials Chemistry and Physics.

The study, “Control of microbial agents by functionalization of commercial air filters with metal oxide particles,” tested various spray coatings of silver (Ag2O), copper (CuO) and zinc (ZnO) oxides as low-cost antiviral and antibacterial filters when applied to commercially available air filtration systems.

Breakthrough: Deaf Boy Can Hear After First Gene Treatment in US

His father’s voice, the sounds of passing cars and scissors clipping his hair: An 11-year-old boy is hearing for the first time in his life after receiving a breakthrough gene therapy.

The Children’s Hospital of Philadelphia (CHOP) which carried out the treatment – a first in the United States – said in a statement Tuesday the milestone represents hope for patients around the world with hearing loss caused by genetic mutations.

Aissam Dam was born “profoundly deaf” because of a highly rare abnormality in a single gene.