Compared to open hemihepatectomy, the laparoscopic approach resulted in faster recovery time and higher quality of life, researchers found. Treatment with laparoscopic hemihepatectomy (resection, or surgical…
Category: biotech/medical – Page 678
New AI tech predicts cardiac events due to coronary inflammation
“The ORFAN study is an expanding global registry which will include long-term clinical and outcome data for 250,000 patients from around the world, and we are very pleased to publish these initial results,” said Keith Channon, MD, Professor of Cardiovascular Medicine at University of Oxford, Caristo Chief Medical Officer, and co-author of The Lancet publication.
“Coronary inflammation is a crucial piece of the puzzle in predicting heart attack risk. We are excited to discover that CaRi-Heart results performed exceptionally well in predicting patient cardiac events. This tool is well positioned to help clinicians identify high-risk patients with seemingly ‘normal’ CCTA scans.”
Ron Blankstein, MD, Professor of Medicine and Radiology at Harvard Medical School, Director of Cardiac Computed Tomography at Brigham and Women’s Hospital, and co-author of the publication, applauded The Lancet for publishing results from one of the largest studies in the field of CCTA.
Targeted Therapy Reduces Immunotherapeutic Neurotoxicity
Immunotherapy is a form of cancer treatment that harnesses the immune system to recognize and target the tumor. In most cancers, the immune system fails to detect the rapid proliferation of tumor cells. Lack of immune cell detection is due to the tumor polarizing or reprogramming immune cells to promote cancer progression and suppress the immune system. This is done through variety of ways including the release of proteins or cytokines that direct immune cell development and function. Current immunotherapies target these polarized immune cells to switch them back toward an anti-tumor function. Although there are many ways to redirect immune cells to attack cancer, immunotherapies maintain limited efficacy due to the immunosuppressive mechanisms within the tumor microenvironment (TME). In addition, heightened toxicity associated with immunotherapy also pose challenges when prescribing treatments to patients.
One immunotherapy that has demonstrated significant promise in cancer patients is chimeric antigen receptor (CAR) T cells are immune cells within the body that are responsible for killing or lysing invading pathogens, including cancer. The immune system orchestrates a response by employing T cells to recognize an infection, in healthy individuals. In the context of cancer, T cells cannot recognize that the tumor is deleterious to the body. Therefore, CAR T cells are generated to reprogram the cell’s ability to recognize and lyse the tumor. CAR T cell therapy takes the patient’s T cells and engineers them to target specific surface markers on the tumor. They are then grown in a dish and expanded before being intravenously reinfused in the patient. CAR T cell therapy is commonly associated with lymphoma, but unfortunately neurotoxicity can be an adverse side effect which limits efficacy.
Violence and aggression against educators grew post-pandemic, survey says
While threats and violence against pre-K to 12th-grade teachers and other school personnel in the United States declined during the pandemic, after the restrictions were lifted, incidents rebounded to levels equal to or exceeding those prior to the pandemic, according to research published in American Psychologist.
As a result, the percentage of teachers expressing intentions to resign or transfer rose from 49% during the pandemic to 57% afterward, the researchers found.
“Aggression and violence against educators and school personnel are major concerns that affect the well-being of school personnel and the students and families they serve. This study highlights a growing crisis in our schools that needs to be addressed nationally,” said lead author Susan Dvorak McMahon, Ph.D., of DePaul University, chair of the APA Task Force on Violence Against Educators and School Personnel. The task force conducted two surveys in collaboration with national education and related organizations.