Lifeboat Foundation

The official body charged with virus classification has released four new principles that bring order to the viral world. This provides a unified framework that will enable all viruses to be classified, something vitally needed as genome technologies continue to discover millions of new virus species.

Since the ancient civilizations of Greece and Egypt, humans have attempted to classify life on Earth by putting organisms into related groups to understand life and infer relationships.

This classification of life, or taxonomy, took a giant step forward in the 18th century when Swedish botanist Carl Linnaeus established a hierarchical classification system that grouped organisms based on common characteristics. Significantly, he developed a Latin naming system that described each organism by group (genera) and specific name (species). Higher ranks brought related genera together into families, families into orders and so on through classes, phyla and kingdoms.

If you ask it the right questions, ChatGPT represents an incredible resource and tool. And people noticed fast — within five days it gained over 1 million users, and now Microsoft is in talks for a potential $10 billion investment in the company.

As a reporter, the hype surrounding the AI tool intrigued me, and a colleague of mine said it’s journalism chops were convincing (though only if you didn’t squint too hard to notice articles were riddle with misinformation).

Knowing that ChatGPT’s database cut off in 2021, I asked it to write a stock market story about trading trends in 2020, and in less than one minute it spat out a 400-word story that mapped out S&P 500 moves, meme stocks, and shares that rallied during the early days of the pandemic.

Researchers from The University of Queensland have discovered the active compound from an edible mushroom that boosts nerve growth and enhances memory.

Professor Frederic Meunier from the Queensland Brain Institute said the team had identified new active compounds from the mushroom, Hericium erinaceus. This type of edible mushroom, commonly known as the Lion’s Mane Mushroom, is native to North America, Europe, and Asia. It is commonly sought after for its unique flavor and texture, and it is also used in traditional Chinese medicine to boost the immune system and improve digestive health.

Researchers have discovered lion’s mane mushrooms improve brain cell growth and memory in pre-clinical trials.

An international team of scientists has found a way to regenerate kidneys damaged by disease, restoring function and preventing kidney failure. The discovery could drastically improve treatments for complications stemming from diabetes and other diseases.

Diabetes causes many problems in the body, but one of the most prevalent is kidney disease. Extended periods of elevated blood sugar can damage nephrons, the tiny filtering units in the kidneys, which can lead to kidney dysfunction and eventually failure.

Continue reading “Scientists regenerate kidneys to reverse diabetes damage in mice” »

Over the past decade, I’ve kept a close eye on the emergence of artificial intelligence in healthcare. Throughout, one truth remained constant: Despite all the hype, AI-focused startups and established tech companies alike have failed to move the needle on the nation’s overall health and medical costs.

Finally, after a decade of underperformance in AI-driven medicine, success is approaching faster than physicians and patients currently recognize.

The next version, ChatGPT4, is scheduled for release later this year, as is Google’s rival AI product. And, last week, Microsoft unveiled an AI-powered search engine and web browser in partnership with OpenAI, with other tech-industry competitors slated to join the fray.

Continue reading “5 Ways ChatGPT Will Change Healthcare Forever, For Better” »

The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the effects of vitamin C therapy on acute kidney injury (AKI) and mortality among septic patients.

Electronic medical records of 1,390 patients from an academic hospital who were categorized as Treatment (received at least one dose of 1.5 g IV vitamin C, n = 212) or Comparison (received no, or less than 1.5 g IV vitamin C, n = 1178) were reviewed. Propensity score matching was conducted to balance a number of covariates between groups. Multivariate logistic regressions were conducted predicting AKI and in-hospital mortality among the full sample and a sub-sample of patients seen in the ICU.

Data revealed that vitamin C therapy was associated with increases in AKI (OR = 2.07 95% CI [1.46–2.93]) and in-hospital mortality (OR = 1.67 95% CI [1.003–2.78]) after adjusting for demographic and clinical covariates. When stratified to examine ICU patients, vitamin C therapy remained a significant risk factor of AKI (OR = 1.61 95% CI [1.09–2.39]) and provided no protective benefit against mortality (OR = 0.79 95% CI [0.48–1.31]).

Amount of toxin present in wheat, which is carcinogenic when heated, can be reduced and grown, new field study confirms Toast could soon be healthier after scientists grew a field of wheat genetically-edited to remove a cancer-causing chemical. Bread, when baked, produces a dangerous toxin called acrylamide, which is believed to be carcinogenic and when toasted is even more lethal.

CRISPR has started moving out of university research laboratories and into the world of human clinical trials.

We are about to see the emergence of a new medical technology, genetic vaccines.

Enhancers change rapidly during evolution, but the mechanisms by which new enhancers originate in the genome are mostly unknown. Not all regions of the genome evolve at the same rate and mutations are elevated at late DNA replication time. To understand the role played by mutational processes in enhancer evolution, we leveraged changes in mutation rates across the genome. By examining enhancer turnover in matched healthy and tumor samples in human individuals, we find while enhancers are most common in early replicating regions, new enhancers emerged more often at late replicating regions. Somatic mutations in cancer are consistently elevated in enhancers that have experienced turnover compared to those that are maintained. A similar relationship with DNA replication time is observed in enhancers across mammalian species and in multiple tissue-types. New enhancers appeared almost twice as often in late compared to early replicating regions, independent of transposable elements. We trained a deep learning model to show that new enhancers are enriched for mutations that modify transcription factor (TF) binding. New enhancers are also typically neutrally evolving, enriched in eQTLs, and are more tissue-specific than evolutionarily conserved enhancers. Accordingly, transcription factors that bind to these enhancers, inferred by their binding sequences, are also more recently evolved and more tissue-specific in gene expression. These results demonstrate a relationship between mutation rate, DNA replication time and enhancer evolution across multiple time scales, suggesting these observations are time-invariant principles of genome evolution.

The authors have declared no competing interest.