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Category: biotech/medical – Page 687

New Technology to Control the Brain Using Magnetic Fields Developed

Nano-MIND Technology for Wireless Control of Brain Circuits with Potential to Modulate Emotions, Social Behaviors, and Appetite.

Researchers at the Center for Nanomedicine within the Institute for Basic Science (IBS) and Yonsei University in South Korea have unveiled a groundbreaking technology that can manipulate specific regions of the brain using magnetic fields, potentially unlocking the secrets of high-level brain functions such as cognition, emotion, and motivation. The team has developed the world’s first Nano-MIND (Magnetogenetic Interface for NeuroDynamics) technology, which allows for wireless, remote, and precise modulation of specific deep brain neural circuits using magnetism.

The human brain contains over 100 billion neurons interconnected in a complex network. Controlling the neural circuits is crucial for understanding higher brain functions like cognition, emotion, and social behavior, as well as identifying the causes of various brain disorders. Novel technology to control brain functions also has implications for advancing brain-computer interfaces (BCIs), such as those being developed by Neuralink, which aim to enable control of external devices through thought alone.

While magnetic fields have long been used in medical imaging due to their safety and ability to penetrate biological tissue, precisely controlling brain circuits with magnetic fields has been a significant challenge for scientists.

Quantum Sensor for the Atomic World Developed through International Scientific Collaboration

In a scientific breakthrough, an international research team from Korea’s IBS Center for Quantum Nanoscience (QNS) and Germany’s Forschungszentrum Jülich developed a quantum sensor capable of detecting minute magnetic fields at the atomic length scale. This pioneering work realizes a long-held dream of scientists: an MRI-like tool for quantum materials.

The research team utilized the expertise of bottom-up single-molecule fabrication from the Jülich group while conducting experiments at QNS, utilizing the Korean team’s leading-edge instrumentation and methodological know-how to develop the world’s first quantum sensor for the atomic world.

The diameter of an atom is a million times smaller than the thickest human hair. This makes it extremely challenging to visualize and precisely measure physical quantities like electric and magnetic fields emerging from atoms. To sense such weak fields from a single atom, the observing tool must be highly sensitive and as small as the atoms themselves.

‘Miracle’ filter turns store-bought LEDs into spintronic devices

In 2021, the same collaborators developed the technology that acts as an active spin filter made of two successive layers of material, called chiral hybrid organic-inorganic halide perovskites. Chirality describes a molecule’s symmetry, where its mirror image cannot be superimposed on itself. Human hands are the classic example; hold yours out, palms facing away. The right and left hands are arranged as mirrors of one another—you can flip your 180° to match the silhouette, but now the right palm is facing you while the left palm faces away. They’re not the same.

Some molecules, such as DNA, sugar and layers of chiral hybrid organic-halide perovskites, have their atoms arranged in chiral symmetry. The filter works by using a “left-handed” oriented chiral layer to allow electrons with “up” spins to pass, but block electrons with “down” spins, and vice versa. At the time, the scientists claimed the discovery could be used to transform conventional optoelectronics into simply by incorporating the chiral spin filter. The new study did just that.

“We took an LED from the shelf. We removed one electrode and put the spin filter material and another regular electrode. And voila! The light was highly circularly polarized,” said Vardeny.

A swinging showerhead leads to discovery of a new mode of vibration in nature

During the hot summer of 2020, confined to his Pasadena home during the COVID-19 pandemic, National Medal of Science-winning applied physicist Amnon Yariv took frequent and long showers to cool off. A surprising result, to go with his record-breaking water bill, was a proposal and theoretical model for a new class of vibrations that can convert a constant force, such as wind or water, to a mechanical oscillation.

Quantum Breakthrough: MRI for Molecules Unlocks Secrets of the Atomic World

A novel quantum sensor with exceptional resolution transforms atomic-level material analysis, paving the way for advancements in quantum technologies and sciences.

In a scientific breakthrough, an international research team from Germany’s Forschungszentrum Jülich and Korea’s IBS Center for Quantum Nanoscience (QNS) developed a quantum sensor capable of detecting minute magnetic fields at the atomic length scale. This pioneering work realizes a long-held dream of scientists: an MRI-like tool for quantum materials.

Quantum Sensor Development

Common Sedative Could Break Consciousness by Tipping Your Brain Into Chaos

A loss of controlled inhibition of overly excited brain cells might explain how a common knock-out anesthesia drug works.

A new animal study led by researchers from the Massachusetts Institute of Technology (MIT) has found that propofol, a sedative used to safely lull people into unconsciousness for medical procedures, disrupts the brain’s normal ability to regain control of highly excitable neurons.

“The brain has to operate on this knife’s edge between excitability and chaos,” explains MIT neuroscientist and senior study author Earl Miller.

In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits

Minimally invasive cellular-level target-specific neuromodulation is needed to decipher brain function and neural circuitry. Here nano-magnetogenetics using magnetic force actuating nanoparticles has been reported, enabling wireless and remote stimulation of targeted deep brain neurons in freely behaving animals.

Enhanced Database AIDS Wildfire Managers in Predicting Fires

“There is a tremendous amount of interest in what enables wildfire ignitions and what can be done to prevent them,” said Dr. Erica Fleishman. “This database increases the ability to access relevant information and contribute to wildfire preparedness and prevention.”

Can wildfires be predicted in advance to allow for safeguards that can prevent their spread? This is what a recent study published in Earth System Science Data hopes to address as a team of researchers have developed a database to help firefighters and power companies establish protocol for implementing strategies that holds the potential for helping to reduce the spread of a wildfire before it gets too large.

Wildfire closure sign seen in the Oregon Cascades in September 2020. (Credit: Oregon State University)

For the study, the researchers presented a revised database as part of the Fire Program Analysis Fire-Occurrence Database, which was created by the U.S. Forest Service in 2013 and has had been revised five times since its inception. Before this study, the database contained basic information like wildfire size, ignition source, and discovery date. However, this the researchers for this study have updated the database with social and environmental factors designed to incorporate social vulnerabilities and even distances from the ignition source to the nearest road.

Cancer Drug Shows Promise for Autism Cognitive Function

Summary: A new experimental cancer drug could ease cognitive difficulties for those with Rett syndrome, a rare autism-linked disorder, by enhancing brain cell functions. The drug, ADH-503, improves the activity of microglia, which are crucial for maintaining neural networks.

Researchers found that healthy microglia restored synapse function in brain organoids mimicking Rett syndrome. This breakthrough suggests potential therapies for Rett syndrome and other neurological conditions.

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