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Brett Adcock: Humanoids Run on Neural Net, Autonomous Manufacturing, and $50 Trillion Market #229

Humanoid robots with full-body autonomy are rapidly advancing and are expected to create a $50 trillion market, transforming industries, economy, and daily life ## ## Questions to inspire discussion.

Neural Network Architecture & Control.

đŸ€– Q: How does Figure 3’s neural network control differ from traditional robotics? A: Figure 3 uses end-to-end neural networks for full-body control, manipulation, and room-scale planning, replacing the previous C++-based control stack entirely, with System Zero being a fully learned reinforcement learning controller running with no code on the robot.

🎯 Q: What enables Figure 3’s high-frequency motor control for complex tasks? A: Palm cameras and onboard inference enable high-frequency torque control of 40+ motors for complex bimanual tasks, replanning, and error recovery in dynamic environments, representing a significant improvement over previous models.

🔄 Q: How does Figure’s data-driven approach create competitive advantage? A: Data accumulation and neural net retraining provides competitive advantage over traditional C++ code, allowing rapid iteration and improvement, with positive transfer observed as diverse knowledge enables emergent generalization with larger pre-training datasets.

🧠 Q: Where is the robot’s compute located and why? A: The brain-like compute unit is in the head for sensors and heat dissipation, while the torso contains the majority of onboard computation, with potential for latex or silicone face for human-like interaction.

The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity

What are the genetic origins of early-onset obesity?

Studying a cohort of young adults in China, researchers in Science TranslationalMedicine performed deep sequencing and identified a loss-of-function variant in the gene TUB that impairs sensitivity to leptin.


Rare human TUB variants impair leptin sensitivity through disruption of STAT3 activation, leading to hyperphagic obesity.

Radiation Therapy Target Objectives For Tonsillar Cancer Treated with Unilateral Radiation Therapy — A Replanning Study From TROG 12.01

New in the RedJournal: replanned TROG 12.01 unilateral cases to define guidelines for unilateral RT planning with maximal midline and contralateral sparing. @TROGfightcancer RadOnc HNcsm.


Unilateral radiotherapy (URT) is an effective treatment strategy in selected patients with lateralized tonsil cancer. However, there is a lack of established planning guidelines for URT treatment leading to suboptimal optimization of contralateral and midline organs at risk (OARs). This study aimed to re-optimize URT plans to maximize sparing of midline and contralateral OAR’s while maintaining target coverage, providing dosimetric guidelines for URT planning.

Cancer Outcomes Across Tumors Predicted by CCL3 Production by Neutrophils

Neutrophils are known as first responders to threatening infections and feature prominently in the microenvironment of tumors to resist cancer progression. Though neutrophils have been linked to the growth of multiple cancers, such as lung and breast, these cells can assume multiple functional states.

In a new study published in Cancer Cell titled, “ CCL3 is produced by aged neutrophils across cancers and promotes tumor growth,” researchers from Ludwig Institute for Cancer Research in Lausanne have discovered a gene expression program executed by tumor-associated neutrophils (TANs) and a corresponding biomarker that uniformly support cancer cell survival and tumor progression across human and murine tumors.

Results demonstrate that TANs characterized by this conserved genetic program are a central variable of the tumor microenvironment (TME) linked to cancer progression. The authors also identify an associated marker, CCL3, as key to supporting cancer growth.

Cancer vaccine shows promise against HPV-related throat tumors in early study

A vaccine designed to fight HPV-driven head and neck cancers has shown promising results in a lab study in human tissues and mice.

If proven effective in humans, the therapeutic shot could complement standard cancer therapies, and its design may help scientists build better vaccines for other diseases.

Abstract: This Research Article adds new information to our understanding of critical illness phenotypes

Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction.


1Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.

2Division of Clinical and Translational Research, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.

3Cardiovascular Research Institute, UCSF, San Francisco, California, USA.

SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring

Vold et al. studied two SNAP-25 variants with different clinical severity. Variants destabilize the SNARE complex and reduce binding to the Munc18-1:VAMP2:syntaxin-1 acceptor complex, with correlated effects on neurotransmitter release. Effects of co-expression of variant and wild-type SNAP-25 were modeled by assuming the co-existence of both species in a ring of SNARE complexes.

Using synthetic biology and AI to address global antimicrobial resistance threat

James J. Collins, the Termeer Professor of Medical Engineering and Science at MIT and faculty co-lead of the Abdul Latif Jameel Clinic for Machine Learning in Health, is embarking on a multidisciplinary research project that applies synthetic biology and generative artificial intelligence to the growing global threat of antimicrobial resistance (AMR).

The research project is sponsored by Jameel Research, part of the Abdul Latif Jameel International network. The initial three-year, $3 million research project in MIT’s Department of Biological Engineering and Institute of Medical Engineering and Science focuses on developing and validating programmable antibacterials against key pathogens.

AMR — driven by the overuse and misuse of antibiotics — has accelerated the rise of drug-resistant infections, while the development of new antibacterial tools has slowed. The impact is felt worldwide, especially in low-and middle-income countries, where limited diagnostic infrastructure causes delays or ineffective treatment.

Digital twin reveals how eye cells lose their organization in leading cause of vision loss

National Institutes of Health (NIH) researchers have developed a digital replica of crucial eye cells, providing a new tool for studying how the cells organize themselves when they are healthy and affected by diseases. The platform opens a new door for therapeutic discovery for blinding diseases such as age-related macular degeneration (AMD), a leading cause of vision loss in people over 50. The study is published in the journal npj Artificial Intelligence.

“This work represents the first-ever subcellular resolution digital twin of a differentiated human primary cell, demonstrating how the eye is an ideal proving ground for developing methods that could be used more generally in biomedical research,” Kapil Bharti, Ph.D., scientific director at the NIH’s National Eye Institute (NEI).

The researchers created a highly detailed, 3D data-driven digital twin of retinal pigment epithelial (RPE) cells, which perform vital recycling and supportive roles to light-sensing photoreceptors in the retina. In diseases such as AMD, RPE cells die, which eventually leads to the death of photoreceptor cells, causing loss of vision.

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