Lifeboat Foundation

We’re way behind several species when it comes to regeneration, and scientists are keen to discover the secrets of these other animals so we can learn from them – including, in a new study, the marine worm Platynereis dumerilii.

These worms are experts in regeneration – they can survive losing a large chunk of their bodies – and now we have a better idea of how they’re doing it: specialized cells near a wound are reverting to their original stem cell-like form, before adapting again to replace lost tissue.

Regeneration in most species is handled by stem cells, which develop into whatever type of cells are needed. However, when the end segment of Platynereis is removed, multiple populations of other cells are recruited to swiftly restore the missing body section.

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Continue reading “17.2y Younger Biological Age (Blood Test #8 In 2024, Test #56 Since 2015)” »

https://www.youtube.com/watch?v=Lk-7wG9Y5hM

An important update on E5.

Here we look at an attempt to replicate the amazing results with E5 from Dr Katcher’s 2020 paper by an institute that has been set up in Brazil.
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Continue reading “Reversing Age by 54% with E5” »

Adding a photocopier gene to mRNA vaccines could make them last longer and curb side effects.

Doshi et al. present a very nice systematic evaluation of minimal requirements for adenoviral helper genes necessary in production of AAVs, as well as some progress towards stable cell lines with integrated helper genes.

The replication-defective adeno-associated virus (AAV) is extensively utilized as a research tool or vector for gene therapy. The production process of AAV remains intricate, expensive, and mechanistically underexplored. With the aim of enhancing AAV manufacturing efficiencies in mammalian cells, we revisited the questions and optimization surrounding the requirement of the various adenoviral helper genes in enabling AAV production. First, we refined the minimal set of adenoviral genes in HEK293 AAV production to E2A, L4-22K/33K, and VA RNA I. These findings challenge the previously accepted necessity of adenoviral E4orf6 in AAV production. In addition, we identified L4-22K genes as crucial helpers for AAV production.

Zhao, N., Zhang, CJ., Zhang, X. et al. npj Regen Med 9, 42 (2024). https://doi.org/10.1038/s41536-024-00387-7

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Young people don’t worry about their health the same way older individuals do. Of course, many Gen Zers and Millenials do prioritize their physical and mental wellbeing. But they are young, while the risk of life-changing conditions like heart disease, diabetes, chronic pain, and cancer increases with age. However, research shows that Gen Z and Millenials are not as safe as once thought. The number of cases of colon cancer has doubled in the United States since the 1990s. Especially in the age 20 to 49 demographic.

Colon cancer is also known as colorectal cancer, bowel cancer, or rectal cancer — depending on where the tumor begins. It’s also called the silent killer because there may be few or zero warning signs. And once the symptoms finally appear, the cancer has already progressed.

Continue reading “Doctors Reveal Surge Behind ‘Silent Killer’ in Gen Z and Millenials and One Way to Reduce the Risk” »

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Stunning images have revealed miles of undersea tunnels connecting a set of islands halfway between Scotland and Iceland.

The Faroe Islands have built 17 tunnels on land and four subsea-including the world’s only underwater roundabout – to deal with its unpredictable weather.

Gallbladder cancer is the latest form of the disease discovered to be rising in people under 50 — alongside bowel, breast and lung.

Data from charity Cancer Research UK (CRUK) show an 84 per cent rise in cases of the gastrointestinal cancer among Brits aged 24–49 since the early 90s.

While a significant increase in cases of the disease has been seen in Brits of all ages, younger adults have seen the largest rise of any age group.