Lifeboat Foundation

Listen now (47 mins) | At the Interface of biomedical science and A.I.

A Ludwig Cancer Research study has punctured a longstanding assumption about the source of the most common type of DNA mutation seen in the genome—one that contributes to many genetic diseases, including cancer.

Led by Ludwig Oxford Leadership Fellow Marketa Tomkova, postdoc Michael McClellan, Assistant Member Benjamin Schuster-Böckler and Associate Investigator Skirmantas Kriaucionis, the study has implications not only for basic cancer biology but also for such things as assessments of carcinogenic risk associated with environmental factors and our understanding of the emergence of drug resistance during cancer therapy. Its findings are reported in the current issue of Nature Genetics.

The mutation in question—in which cytosine ©, one of the four bases of DNA that spell out our genes, is erroneously switched to thymine (T)—was thought to be primarily the result of a spontaneous chemical reaction with water. This reaction, deamination, is about twice as likely to happen when a cytosine is chemically tagged by the addition of a molecule known as a methyl group to create 5-methylcytosine, which occurs in DNA at so-called “CpG” positions, where C is followed by the base guanine (G).

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Researchers from the Sapienza University of Rome found that caffeine has a positive effect on endothelial cells, a group of cells responsible for vascular regeneration.

We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.

Methods.

Continue reading “Caffeine improves systemic lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival” »

Although intracranial atherosclerotic disease (ICAD) is a known risk factor for cerebrovascular ischemic events, its potential role in dementia risk remains unclear. The Atherosclerosis Risk in Communities (ARIC) study was a prospective cohort study that recruited participants from four U.S. communities. From 2011 to 2013, a subset comprising 1,590 participants (mean age, 77; 40% men; 28% Black) underwent ICAD evaluation and neurocognitive testing to ascertain the prospective association of ICAD with dementia risk, independent of other known cardiovascular risk factors. ICAD was diagnosed based on focal-wall thickness on brain MRI, with or without luminal stenosis on magnetic resonance angiography (MRA).

During a median follow-up of 5.6 years, 286 cases of incident dementia were observed. After adjustment for established dementia risk factors, including cardiovascular risk factors, patients with ICAD (regardless of luminal stenosis) had an independently higher risk for incident dementia than those without ICAD (HR, 1.57; 95% CI, 1.17–2.11). The presence of stenosis 50% on MRA was associated with even higher risk (HR, 1.89; 95% CI, 1.29–2.78). An important limitation was the investigators’ inability to determine dementia subtypes.

This prospective trial adds further observational evidence that ICAD is independently associated with dementia. Furthermore, this study provides evidence that earlier stages of atherosclerosis (i.e., involvement of the arterial wall without luminal narrowing) are also associated with increased risk. While the pathophysiology of this association has yet to be elucidated, I will counsel my patients with ICAD about this association and will strongly recommend proven management strategies (e.g., smoking cessation, lipid lowering) to mitigate vascular disease progression, given the higher risk of dementia in those with luminal disease.

Engineers have worked out how to give robots complex instructions without electricity for the first time which could free up more space in the robotic ‘brain’ for them to ‘think’

Mimicking how some parts of the human body work, researchers from King’s College London have transmitted a series of…

Continue reading “New breakthrough helps free up space for robots to ‘think’, say scientists” »

Human Immortality — If you thought Human Immortality was just a concept in science fiction, this episode reveals how it will become science fact. For some scientists featured in this program, achieving Immortality is not a question of ‘If’. The real question is ‘When?’

Human Immortality (2022)
Director: Emma Watts.
Writers: Kyle McCabe, Christopher Webb Young.
Stars: Samantha Brady, Aubrey DeGrey, Leonard Guarente.
Genre: Documentary.
Country: United States.
Language: English.
Release Date: August 31, 2022 (United States)

Continue reading “Human Immortality | Life Extension | YouTube Documentary” »

Source: University of Pittsburgh.

Higher levels of HDL-C—known as the “good cholesterol”—have been shown to correlate with heightened risk for Alzheimer’s disease.

A new study published in the Journal of Clinical Endocrinology & Metabolism might explain why.

Duke University engineers are layering atom-thick lattices of carbon with polymers to create unique materials with a broad range of applications, including artificial muscles.

The lattice, known as graphene, is made of pure carbon and appears under magnification like chicken wire. Because of its unique optical, electrical, and mechanical properties, graphene is used in electronics, energy storage, composite materials, and biomedicine.