Physical non-equilibria can drive cycles of replication and selection chemistries that play a role in the prebiotic replication of DNA and RNA. This Perspective offers insights from astrophysics, geoscience and microfluidics on how various environments on early Earth could have hosted such reactions.

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, according to a new study from researchers at Weill Cornell Medicine. The finding solves a 50-year mystery concerning the purpose of these chemical modifications, and suggests that faulty mRNA modification may underlie some autoimmune and inflammatory disorders.

Pharmaceutical synthesis is often quite complex; simplifications are needed to speed up the initial phase of drug development and lower the cost of generic production. Now, in a study recently published in Science, researchers from Osaka University have discovered a chemical reaction that could transform drug production because of its simplicity and utility.

Pharmaceuticals generally contain a few tens of atoms and a similar number of chemical bonds between the atoms. Thus, designing complex drug architectures from simple precursors using the techniques of organic chemistry usually requires careful planning and tedious, incremental steps.

The gold standard in drug synthesis is to create, in one step, as many chemical bonds as possible. In principle, adding one carbon atom—by forming four bonds in one step—to a drug precursor can be a means of doing so. Unfortunately, atomic carbon is generally too unstable for use in common chemical reaction conditions. This is the problem that the researchers sought to address.

The study was undertaken by Yasuhiro Oba’s team from Hokkaido University in Japan and astrochemists at NASA. A few years ago, Oba developed a technique to delicately excavate and separate different chemical compounds found in meteorite dust.

Using their mild extraction technique that uses cold water instead of acids, scientists found life-creating bases and compounds in four meteorite samples from Australia, US state of Kentucky, and Canadian province of British Columbia.

The discovery of these compounds in meteorites means that it is possible life on Earth as it stands today was created by compounds that came from outer space.