Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: chemistry – Page 205

The CD was initially soaked in 40 mL of acetone for 1.5 minutes, releasing the metal layer by breaking down the polycarbonate substrate. The metal from the CD was easily harvested with polyimide tape, which also serves as the substrate layer in the new device integration to improve the mechanical durability and robustness of the thin metal film.

“When you pick up your hair on your clothes with sticky tape, that is essentially the same mechanism,” said Assistant Professor Ahyeon Koh, who led the research. “We loosen the layer of metals from the CD and then pick up that metal layer with tape, so we just peel it off. That thin layer is then processed and flex ible.”

Researchers created the sensors utilizing a commercially available Cricut cutter, an off-the-shelf machine for crafters that generally cut designs from materials like paper, vinyl, card stock, and iron-on transfers. The flexible circuits then would be removed and stuck onto a person. The whole fabrication process was completed in 20–30 minutes, without releasing toxic chemicals or needing expensive equipment, and it costs about $1.50 per device.

Read more | >

Nowadays, the development of renewable energy sources, such as wind, solar, and nuclear energy sources, has become imperative, due to the limited resource constraints of the traditional fossil fuels [1 ]. However, these renewable sources could not deliver a regular power supply as the sources are variable in time and diffuse in space. Thus, the focus has been shifted to the electrical energy storage to smooth the intermittency of the energy sources. Rechargeable battery has the ability to store chemical energy and convert it into electrical energy with high efficiency [ 2]. Lithium-ion battery (LIB), as one typical rechargeable electrochemical battery, has dominated the markets of portable electronic devices, electric vehicles, and hybrid electric vehicles in the past decades, due to its high output voltages, high energy densities, and long cycle life; even though the high cost and the shortage of lithium resources are inhibiting the application of LIB in large-scale energy storage [[3], [4], [5], [6], [7], [8], [9]].

Sodium-ion battery (SIB) is one promising alternative to LIB, with comparable performance to that of LIB, abundant sodium resources and low price of starting materials [[10], [11], [12], [13]]. As Na atom is heavier and larger than those of Li atom, the gravimetric and volumetric energy density of Na-ion battery are expected to not exceed those of the Li analogues [14]. However, energy density would not be considered as the critical issue in the field of large-scale grid support, for which the operating cost and the battery durability are the most important aspects [15,16].

Read more | >

A novel bioremediation technology for cleaning up per-and polyfluoroalkyl substances, or PFAS, chemical pollutants that threaten human health and ecosystem sustainability, has been developed by Texas A&M AgriLife researchers. The material has potential for commercial application for disposing of PFAS, also known as “forever chemicals.”

Published July 28 in Nature Communications, the was a collaboration of Susie Dai, Ph.D., associate professor in the Texas A&M Department of Plant Pathology and Microbiology, and Joshua Yuan, Ph.D., chair and professor in Washington University in St. Louis Department of Energy, Environmental and Chemical Engineering, formerly with the Texas A&M Department of Plant Pathology and Microbiology.

Removing PFAS contamination is a challenge

PFAS are used in many applications such as food wrappers and packaging, dental floss, fire-fighting foam, nonstick cookware, textiles and electronics. These days, PFAS are widely distributed in the environment from manufacturing or from products containing the chemicals, said Dai.

Read more | >

Four billion years ago, the Earth looked very different than it does today, devoid of life and covered by a vast ocean. Over the course of millions of years, in that primordial soup, life emerged. Researchers have long theorized how molecules came together to spark this transition. Now, scientists at Scripps Research have discovered a new set of chemical reactions that use cyanide, ammonia and carbon dioxide—all thought to be common on the early earth—to generate amino acids and nucleic acids, the building blocks of proteins and DNA.

“We’ve come up with a new paradigm to explain this shift from prebiotic to biotic chemistry,” says Ramanarayanan Krishnamurthy, Ph.D., an associate professor of chemistry at Scripps Research, and lead author of the new paper, published July 28, 2022 in the journal Nature Chemistry. “We think the kind of reactions we’ve described are probably what could have happened on .”

In addition to giving researchers insight into the chemistry of the early earth, the newly discovered chemical reactions are also useful in certain , such as the generation of custom labeled biomolecules from inexpensive starting materials.

Read more | >

Perovskite solar cells (PSCs) are promising solar technologies. Although low-cost wet processing has shown advantages in small-area PSC fabrication, the preparation of uniform charge transport layers with thickness of several nanometers from solution for meter-sized large area products is still challenging.

Recently, a research group led by Prof. LIU Shengzhong from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has developed a facile surface redox engineering (SRE) strategy for vacuum-deposited NiO x to match the slot-die-coated perovskite, and fabricated high-performance large-area perovskite submodules.

This work was published in Joule (“Surface redox engineering of vacuum-deposited NiO x for top-performance perovskite solar cells and modules”).

Read more | >

A single chemical could be responsible for whether people go bald or not, a new study has found.

In the UK, approximately two thirds of men will face male pattern baldness. The study says the discovery of the chemical could “not only treat baldness, but ultimately speed wound healing”.

Researchers at the University of California, Riverside, found that a sole chemical is responsible for hair follicles dividing and dying.

Read more | >

The platform, still in the early development phase, is called Druglike, according to a press release that circulated on July 25. Its goals are ostensibly lofty, but the details are extremely sketchy, and Shkreli’s intentions have already drawn skepticism. It’s also unclear whether the enterprise will run Shkreli afoul of his lifetime ban from the pharmaceutical industry, which stemmed from the abrupt and callous 4,000 percent price hike of a life-saving drug that made him infamous.

Shkreli, who is named as a cofounder of Druglike, says the platform aims to make early-stage drug discovery more affordable and accessible. “Druglike will remove barriers to early-stage drug discovery, increase innovation and allow a broader group of contributors to share the rewards,” Shkreli said in the press release. “Underserved and underfunded communities, such as those focused on rare diseases or in developing markets, will also benefit from access to these tools.”

Generally, early-stage drug development can sometimes involve virtual screens to identify potential drug candidates. In these cases, pharmaceutical scientists first identify a “target”—a specific compound or protein that plays a critical role in developing a disease or condition. Then researchers look for compounds or small molecules that could interfere with that target, sometimes binding or “docking” directly to the target in a way that keeps it from functioning. This can be done in physical labs using massive libraries of compounds in high-throughput chemical screens. But it can also be done virtually, using specialized software and a lot of computing power, which can be resource-intensive.

The Virus Zoo is my latest educational blog post! I’ve written up ~1 page ‘cheat sheets’ on the molecular biology of specific viruses. I cover genome, structure, and life cycle. So far, my zoo includes adeno-associated virus (AAV), adenovirus, and herpes simplex virus 1 (HSV-1). However, I plan to add more viruses as time goes on! Some others I would like to incorporate later are coronavirus, HIV, anellovirus, lentivirus, ebolavirus, and MS2 bacteriophage. Feel free to suggest other interesting viruses in the comments! All images were created by me. #virology #molecularbiology #biotechnology #genetherapy #virus #biochemistry #genetics

Genome and Structure:

AAV genomes are about 4.7 kb in length and are composed of ssDNA. Inverted terminal repeats (ITRs) form hairpin structures at ends of the genome. These ITR structures are important for AAV genomic packaging and replication. Rep genes (encoded via overlapping reading frames) include Rep78, Rep68, Rep52, Rep40.1 These proteins facilitate replication of the viral genome. As a Dependoparvovirus, additional helper functions from adenovirus (or certain other viruses) are needed for AAVs to replicate.

AAV capsids are about 25 nm in diameter. Cap genes include VP1, VP2, VP3 and are transcribed from overlapping reading frames.2 The VP3 protein is the smallest capsid protein. The VP2 protein is the same as VP3 except that it includes an N-terminal extension with a nuclear localization sequence. The VP1 protein is the same as VP2 except that it includes a further N-terminal extension encoding a phospholipase A2 (PLA2) that facilitates endosomal escape during infection. In the AAV capsid, VP1, VP2, and VP3 are present at a ratio of roughly 1:1:10. It should be noted that this ratio is actually the average of a distribution, not a fixed number.

Continue reading “The Virus Zoo: A Quick Primer on Molecular Virology” | >

As more drivers adopt plug-in hybrid and electric vehicles, the demand for lithium-ion batteries will continue to explode over the next decade. But processes for extracting lithium can be time-consuming and chemical-intensive, and traditional sources—including brine and hard rock—could ultimately be depleted.

Scientists and engineers are now looking to unconventional sources, including oil-and gas-produced water, geothermal brines, and rejected brines from seawater desalination. But how much lithium lies within these sources, and how to best extract it, remains an open question.

Asst. Prof. Chong Liu’s team now has the answer. By analyzing more than 122,000 unconventional water sources, she and her team discovered that there is, in fact, enough lithium within these sources to make it worthwhile to extract.

Read more | >