Lifeboat Foundation

As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus.

University of South Florida Health (USF Health) Morsani College of Medicine scientists recently worked with colleagues at the University of Arizona College of Pharmacy to identify several existing compounds that block replication of the COVID-19 virus (SARS-CoV-2) within human cells grown in the laboratory. The inhibitors all demonstrated potent chemical and structural interactions with a viral protein critical to the virus’s ability to proliferate.

The research team’s drug discovery study appeared June 15 in Cell Research, a high-impact Nature journal.

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According to the study in PNAS, the ultra-thin yet strong material acts as a barrier that mosquitoes can’t bite through. The graphene also blocks chemical signals mosquitoes use to sense that a blood meal is near, blunting their urge to bite in the first place.

NASA is bringing the smell of space to Earth with a new fragrance called Eau de Space. The fragrance was developed by chemist Steve Pearce, who was contracted by NASA in 2008 to recreate the scent of space.

With his knowledge of flavor and fragrance chemistry, Pearce used astronauts’ descriptions of the smell of space to come up with combinations to match what was described as “ozone, hot metal, and fried steak,” CNN reports.

“It’s a bitter kind of smell in addition to being smoky and burned, kind of like a smell from a gun, right after you fire the shot,” astronaut Peggy Whitson told CNN. Eau de Space product manager, Matt Richmond, said he has struggled to accurately describe the fragrance’s scent, adding that astronauts have also likened the smell to “a mix of gunpowder, seared steak, raspberries, and rum.”

New research from the University of Colorado Boulder has offered some of the clearest evidence to date showing how the gut microbiome produces a metabolite that, over time, contributes to age-related declines in cardiovascular health.

High blood levels of trimethylamine-N-Oxide (TMAO), a metabolic byproduct of digestion, have been strongly linked to negative cardiovascular health. When one eats red meat, eggs or other animal proteins, certain types of gut bacteria feed on chemicals in those foods and produce TMA, or trimethylamine, which is then turned into TMAO in the liver.

A number of studies have linked TMAO to heart disease, however, until now it hasn’t been clear exactly how this metabolite causes cardiovascular damage. A robust new study, published in the journal Hypertension, is offering one of the first thorough mechanistic investigations illustrating how TMAO damages the cardiovascular system.

Brain-inspired computing paradigms have led to substantial advances in the automation of visual and linguistic tasks by emulating the distributed information processing of biological systems. The similarity between artificial neural networks (ANNs) and biological systems has inspired ANN implementation in biomedical interfaces including prosthetics and brain-machine interfaces. While promising, these implementations rely on software to run ANN algorithms. Ultimately, it is desirable to build hardware ANNs that can both directly interface with living tissue and adapt based on biofeedback. The first essential step towards biologically integrated neuromorphic systems is to achieve synaptic conditioning based on biochemical signalling activity. Here, we directly couple an organic neuromorphic device with dopaminergic cells to constitute a biohybrid synapse with neurotransmitter-mediated synaptic plasticity. By mimicking the dopamine recycling machinery of the synaptic cleft, we demonstrate both long-term conditioning and recovery of the synaptic weight, paving the way towards combining artificial neuromorphic systems with biological neural networks.

A USC Dornsife chemistry professor’s bet on a student proposal leads to new understanding of what defines a metal — and lands the cover of Science.

Ryan McMullen had never heard of the USC Dornsife College of Letters, Arts and Sciences when he started casting about for a graduate chemistry program. But on the recommendation of one of his professors, he sent an email to the College’s Professor of Chemistry Stephen Bradforth proposing an experiment to tease out what makes a metal really a metal.

Continue reading “Results of an Experiment” »

Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic components or the transmission of signals. High-frequency electromagnetic fields can only be shielded with conductive shells that are closed on all sides. Often thin metal sheets or metallized foils are used for this purpose. However, for many applications such a shield is too heavy or too poorly adaptable to the given geometry. The ideal solution would be a light, flexible and durable material with extremely high shielding effectiveness.

Aerogels against electromagnetic radiation

A breakthrough in this area has now been achieved by a research team led by Zhihui Zeng and Gustav Nyström. The researchers are using nanofibers of cellulose as the basis for an aerogel, which is a light, highly porous material. Cellulose fibers are obtained from wood and, due to their chemical structure, enable a wide range of chemical modifications. They are therefore a highly popular research object. The crucial factor in the processing and modification of these cellulose nanofibres is to be able to produce certain microstructures in a defined way and to interpret the effects achieved. These relationships between structure and properties are the very field of research of Nyström’s team at Empa.

face_with_colon_three Circa 2012

Scientists have been able to generate the world’s fastest laser pulse with a beam shot for 67 attoseconds (0.000000000000000067 seconds). This breaks the previous record of 80 attoseconds that was established in 2008. This could help engineers see extremely rapid quantum mechanical processes, like the movements of electrons during chemical reactions.

The researchers published their findings in the journal Optics Letters. This will allow the study of electron motions with attosecond pulses. The blast was obtained by sending pulses from a titanium-sapphire near-infrared laser through a system known as double optical gating (DOG) in which the gate concentrates the energy of extreme ultraviolet light pulses and focuses them on a cell filled with neon gas.

If there’s one myth that has persisted through the years without much evidence, it’s this: multiply your dog’s age by seven to calculate how old they are in “human years.” In other words, the old adage says, a four-year-old dog is similar in physiological age to a 28-year-old person.

But a new study by researchers at University of California San Diego School of Medicine throws that out the window. Instead, they created a formula that more accurately compares the ages of humans and dogs. The formula is based on the changing patterns of methyl groups in dog and human genomes — how many of these chemical tags and where they’re located — as they age. Since the two species don’t age at the same rate over their lifespans, it turns out it’s not a perfectly linear comparison, as the 1:7 years rule-of-thumb would suggest.