Lifeboat Foundation

The way the team made the human–monkey embryo is similar to previous attempts at half-human chimeras.

Here’s how it goes. They used de-programmed, or “reverted,” human stem cells, called induced pluripotent stem cells (iPSCs). These cells often start from skin cells, and are chemically treated to revert to the stem cell stage, gaining back the superpower to grow into almost any type of cell: heart, lung, brain…you get the idea. The next step is preparing the monkey component, a fertilized and healthy monkey egg that develops for six days in a Petri dish. By this point, the embryo is ready for implantation into the uterus, which kicks off the whole development process.

This is where the chimera jab comes in. Using a tiny needle, the team injected each embryo with 25 human cells, and babied them for another day. “Until recently the experiment would have ended there,” wrote Drs. Hank Greely and Nita Farahany, two prominent bioethicists who wrote an accompanying expert take, but were not involved in the study.

Circa 2019

As quantum computing enters the industrial sphere, questions about how to manufacture qubits at scale are becoming more pressing. Here, Fernando Gonzalez-Zalba, Tsung-Yeh Yang and Alessandro Rossi explain why decades of engineering may give silicon the edge.

In the past two decades, quantum computing has evolved from a speculative playground into an experimental race. The drive to build real machines that exploit the laws of quantum mechanics, and to use such machines to solve certain problems much faster than is possible with traditional computers, will have a major impact in several fields. These include speeding up drug discovery by efficiently simulating chemical reactions; better uses of “big data” thanks to faster searches in unstructured databases; and improved weather and financial-market forecasts via smart optimization protocols.

Continue reading “Manufacturing silicon qubits at scale” »

Researchers have developed a way to dynamically switch the surface of liquidmetal between reflective and scattering states. This technology could one day be used to create electrically controllable mirrors or illumination devices.

Liquid metals combine the electrical, thermal and optical properties of metals with the fluidity of a liquid. The new approach uses an electrically driven chemical reaction to create switchable reflective surfaces on a liquid metal. No optical coatings nor polishing steps, which are typically required to make reflective optical components, are necessary to make the liquid metal highly reflective.

In the Optical Society (OSA) journal Optical Materials Express, researchers led by Yuji Oki of Kyushu University in Japan show that switching between reflective and scattering states can be achieved with just 1.4 V, about the same voltage used to light a typical LED. The researchers collaborated with Michael D. Dickey’s research team at North Carolina State University to develop the new method, which can be implemented at ambient temperature and pressures.

Circa 2018

The death-cap mushroom has a long history as a tool of murder and suicide, going back to ancient Roman times. The fungus, Amanita phalloides, produces one of the world’s deadliest toxins: α-amanitin. While it may seem ill-advised, researchers are eager to synthesize the toxin because studies have shown that it could help fight cancer. Scientists now report in the Journal of the American Chemical Society how they overcame obstacles to synthesize the death-cap killer compound.

α-Amanitin achieves its impressive deadliness by acting as a potent inhibitor of RNA polymerase II, the enzyme primarily responsible for transcribing genes into the messenger molecule RNA. Using α-amanitin bound to antibodies against tumor molecules, cancer researchers have reportedly cured mice of pancreatic cancer. These conjugates are currently in human trials; however, the only way to obtain α-amanitin so far has been to harvest mushrooms, which is time-consuming and results in relatively small amounts of the compound. Synthetic production approaches have been hampered by α-amanitin’s unusual bicyclic structure, among other tricky features. David M. Perrin and colleagues decided to take on the challenge to produce the toxin in the laboratory, once and for all.

The researchers had to work through three key obstacles to produce α-amanitin in the laboratory: production of the “oxidatively delicate” 6-hydroxy-tryptathionine, the an enantio-selective synthesis of (2 S, 3 R, 4 R)-4, 5-dihydroxy-isoleucine and a diastereoselective sulfoxidation to favor the (R)-sulfoxide. Due to its toxic nature, the researchers limited production to less than a milligram, but based on their results, they are confident that good yields are can be readily obtained by scaling up the process. The researchers also say that the development of this synthetic route will enable chemists to attenuate the toxicity and potentially improve α-amanitin’s activity against cancer, something that is only made possible by the use of synthetic derivatives.

A long-held goal by chemists across many industries, including energy, pharmaceuticals, energetics, food additives and organic semiconductors, is to imagine the chemical structure of a new molecule and be able to predict how it will function for a desired application. In practice, this vision is difficult, often requiring extensive laboratory work to synthesize, isolate, purify and characterize newly designed molecules to obtain the desired information.

Recently, a team of Lawrence Livermore National Laboratory (LLNL) materials and computer scientists have brought this vision to fruition for energetic molecules by creating machine learning (ML) models that can predict molecules’ crystalline properties from their chemical structures alone, such as molecular density. Predicting crystal structure descriptors (rather than the entire crystal structure) offers an efficient method to infer a material’s properties, thus expediting materials design and discovery. The research appears in the Journal of Chemical Information and Modeling.

“One of the team’s most prominent ML models is capable of predicting the crystalline density of energetic and energetic-like molecules with a high degree of accuracy compared to previous ML-based methods,” said Phan Nguyen, LLNL applied mathematician and co-first author of the paper.

There may be life in Enceladus’ deep sea plumes.

The Cassini probe revealed a subsurface ocean beneath Enceladus’ icy surface that may be habitable. A new analysis shows that the chemistry has the right stuff.

The US Defense Advanced Research Projects Agency (DARPA) has recently commissioned three private companies, Blue Origin, Lockheed Martin and General Atomics, to develop nuclear fission thermal rockets for use in lunar orbit.

Such a development, if flown, could usher in a new era of spaceflight. That said, it is only one of several exciting avenues in rocket propulsion. Here are some others.

The standard means of propulsion for spacecraft uses chemical rockets. There are two main types: solid-fueled (such as the solid rocket boosters on the Space Shuttle), and liquid-fueled (such as the Saturn V).

In a decade-long quest, scientists at Berkeley Lab, the University of Hawaii, and Florida International University uncover new clues to the origins of the universe – and land new chemistry for cleaner combustion engines.

For nearly half a century, astrophysicists and organic chemists have been on the hunt for the origins of C₆H₆, the benzene ring – an elegant, hexagonal molecule comprised of 6 carbon and 6 hydrogen atoms.

Astrophysicists say that the benzene ring could be the fundamental building block of polycyclic aromatic hydrocarbons or PAHs, the most basic materials formed from the explosion of dying, carbon-rich stars. That swirling mass of matter would eventually give shape to the earliest forms of carbon – precursors to molecules some scientists say are connected to the synthesis of the earliest forms of life on Earth.

The Future Bathroom is Here. Clean. Effortless. Chemical-Free.