Lifeboat Foundation

Glass, rubber and plastics all belong to a class of matter called amorphous solids. And in spite of how common they are in our everyday lives, amorphous solids have long posed a challenge to scientists.

Since the 1910s, scientists have been able to map in 3D the atomic structures of crystals, the other major class of solids, which has led to myriad advances in physics, chemistry, biology, materials science, geology, nanoscience, drug discovery and more. But because amorphous solids aren’t assembled in rigid, repetitive atomic structures like crystals are, they have defied researchers’ ability to determine their atomic structure with the same level of precision.

Until now, that is.

Bipolar disorder affects millions of Americans, causing dramatic swings in mood and, in some people, additional effects such as memory problems.

While bipolar disorder is linked to many genes, each one making small contributions to the disease, scientists don’t know just how those genes ultimately give rise to the disorder’s effects.

However, in new research, scientists at the University of Wisconsin-Madison have found for the first time that disruptions to a particular protein called Akt can lead to the brain changes characteristic of bipolar disorder. The results offer a foundation for research into treating the often-overlooked cognitive impairments of bipolar disorder, such as memory loss, and add to a growing understanding of how the biochemistry of the brain affects health and disease.

The companies attempting to avoid transparency.

Jerry Lehnert.

· 1tSpohntsnorted ·

Continue reading “State’s Largest Business Lobby Sues Environmental Regulators Over PFAS Sampling Of Wastewater” »

SYNTHETIC cells made by combining components of Mycoplasma bacteria with a chemically synthesised genome can grow and divide into cells of uniform shape and size, just like most natural bacterial cells.

In 2016, researchers led by Craig Venter at the J. Craig Venter Institute in San Diego, California, announced that they had created synthetic “minimal” cells. The genome in each cell contained just 473 key genes thought to be essential for life.

For the first time, a team of scientists has created a synthetic single-celled organism that can divide and grow like a regular living cell. This breakthrough could lead to designer cells that can produce useful chemicals on demand or treat disease from inside the body.

This new study, by scientists from the J. Craig Venter Institute (JCVI), the National Institute of Standards and Technology (NIST) and MIT, builds on over a decade’s work in creating synthetic lifeforms. In 2010 a JCVI team created the world’s first cell with a synthetic genome, which they dubbed JCVI-syn1.0.

In 2016, the researchers followed that up with JCVI-syn3.0, a version where the goal was to make the organism as simple as possible. With only 473 genes, it was the simplest living cell ever known – by comparison, an E. coli bacterium has well over 4000 genes. But perhaps it was too simple, because the cells weren’t all that effective at dividing. Rather than uniform shapes and sizes, some of them would form filaments and others wouldn’t fully separate.

CLEVELAND, Ohio — The Cleveland Clinic and IBM have entered a 10-year partnership that will install a quantum computer — which can handle large amounts of data at lightning speeds — at the Clinic next year to speed up medical innovations.

The Discovery Accelerator, a joint Clinic-IBM center, will feature artificial intelligence, hybrid cloud data storage and quantum computing technologies. A hybrid cloud is a data storage technology that allows for faster storage and analysis of large amounts of data.

The partnership will allow Clinic researchers to use the advanced tech in its new Global Center for Pathogen Research and Human Health for research into genomics, population health, clinical applications, and chemical and drug discovery.

More than 25 years ago, biologists in Arkansas began to report dozens of bald eagles paralyzed, convulsing, or dead. Their brains were pocked with lesions never seen before in eagles. The disease was soon found in other birds across the southeastern United States. Eventually, researchers linked the deaths to a new species of cyanobacteria growing on an invasive aquatic weed that is spreading across the country. The problem persists, with the disease detected regularly in a few birds, yet the culprit’s chemical weapon has remained unknown.

Today in Science, a team identifies a novel neurotoxin produced by the cyanobacteria and shows that it harms not just birds, but fish and invertebrates, too. “This research is a very, very impressive piece of scientific detective work,” says microbiologist Susanna Wood of the Cawthron Institute. An unusual feature of the toxic molecule is the presence of bromine, which is scarce in lakes and rarely found in cyanobacteria. One possible explanation: the cyanobacteria produce the toxin from a bromide-containing herbicide that lake managers use to control the weed.

The discovery highlights the threat of toxic cyanobacteria that grow in sediment and on plants, Wood says, where routine water quality monitoring might miss them. The finding also equips researchers to survey lakes, wildlife, and other cyanobacteria for the new toxin. “It will be very useful,” says Judy Westrick, a chemist who studies cyanobacterial toxins at Wayne State University and was not involved in the new research. “I started jumping because I got so excited.”

Stanford University neurobiologist Sergiu Pașca has been making brain organoids for about 10 years, and his team has learned that some of these tissue blobs can thrive in a dish for years. In the new study, they teamed up with neurogeneticist Daniel Geschwind and colleagues at the University of California, Los Angeles (UCLA), to analyze how the blobs changed over their life spans…

…They noticed that when an organoid reached 250 to 300 days old—roughly 9 months—its gene expression shifted to more closely resemble that of cells from human brains soon after birth. The cells’ patterns of methylation—chemical tags that can affix to DNA and influence gene activity—also corresponded to increasingly mature human brain cells as the organoids aged, the team reports today in Nature Neuroscience.

Organoids develop genetic signatures of postnatal brains, possibly broadening their use as disease models.

Continue reading “Brain cell clusters, grown in lab for more than a year, mirror changes in a newborn’s brain” »

Doctors take a microscopic craft loaded with cancer-killing chemicals, inject it into the human body, and drive it to a malignant tumor to deliver its payload before making a quick exit. The plan is to move to clinical trials by 2023.

Chemotherapy and radiation can cause too much collateral damage to treat some brain tumors. Crumb-sized robots could be the solution.