Lifeboat Foundation

Here, we discover prototypical pacemaker neurons in the ancient cnidarian Hydra and provide evidence for a direct interaction of these neurons with the commensal microbiota. We uncover a remarkable gene-expression program conservation between the Hydra pacemaker neurons and pacemaker cells in Caenorhabditis elegans and the mammalian gut. We suggest that prototypical pacemaker cells emerged as neurons using components of innate immunity to interact with the microbial environment and ion channels to generate rhythmic contractions. The communication of pacemaker neurons with the microbiota represents a mechanistic link between the gut microbiota and gut motility. Our discoveries improve the understanding of the archetypical properties of the enteric nervous systems, which are perturbed in human dysmotility-related conditions.

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of these neurons and their interaction with microbes. In this study, we identified and functionally characterized prototypical ANO/SCN/TRPM ion channel-expressing pacemaker cells in the basal metazoan Hydra by using a combination of single-cell transcriptomics, immunochemistry, and functional experiments. Unexpectedly, these prototypical pacemaker neurons express a rich set of immune-related genes mediating their interaction with the microbial environment.

Kansas State University physicists have taken extremely fast snapshots of light-induced molecular ring-opening reactions—similar to those that help a human body produce vitamin D from sunlight. The research is published in Nature Chemistry.

“Think of this as stop-motion like a cartoon,” said Daniel Rolles, associate professor of physics and the study’s principal investigator. “For each molecule, you start the reaction with a laser pulse, take snapshots of what it looks like as time passes and then put them together. This creates a ‘molecular movie’ that shows how the electronic structure of the molecule changes as a function of how much time passes between when we start and when we stop.”

Shashank Pathak, doctoral student and lead author on the paper, said the idea was to study the dynamics of how a ring opens in a molecule on the time scale of femtosecond, which is one quadrillionth of a second. The researchers use a free-electron laser to visualize how these reactions happen by recording electron energy spectra as the atoms in the molecule move apart.

Researchers at Tel Aviv University, led by Prof. Yaniv Assaf of the School of Neurobiology, Biochemistry and Biophysics and the Sagol School of Neuroscience and Prof. Yossi Yovel of the School of Zoology, the Sagol School of Neuroscience, and the Steinhardt Museum of Natural History, conducted a first-of-its-kind study designed to investigate brain connectivity in 130 mammalian species. The intriguing results, contradicting widespread conjectures, revealed that brain connectivity levels are equal in all mammals, including humans.

“We discovered that brain connectivity —namely the efficiency of information transfer through the neural network —does not depend on either the size or structure of any specific brain,” says Prof. Assaf. “In other words, the brains of all mammals, from tiny mice through humans to large bulls and dolphins, exhibit equal connectivity, and information travels with the same efficiency within them. We also found that the brain preserves this balance via a special compensation mechanism: when connectivity between the hemispheres is high, connectivity within each hemisphere is relatively low, and vice versa.”

Participants included researchers from the Kimron Veterinary Institute in Beit Dagan, the School of Computer Science at TAU and the Technion’s Faculty of Medicine. The paper was published in Nature Neuroscience on June 8.

DNA usually forms the classic double helix shape discovered in 1953—two strands wound around each other. Several other structures have been formed in test tubes, but this does not necessarily mean they form within living cells.

Quadruple helix structures, called DNA G-quadruplexes (G4s), have previously been detected in cells. However, the technique used required either killing the cells or using high concentrations of chemical probes to visualise G4 formation, so their actual presence within living cells under normal conditions has not been tracked, until now.

A research team from the University of Cambridge, Imperial College London and Leeds University have invented a fluorescent marker that is able to attach to G4s in living human cells, allowing them to see for the first time how the structure forms and what role it plays in cells.

Yesterday, Regeneron Pharmaceuticals, with the U.S. National Institute of Allergy and Infectious Diseases (NIAID), announced it was launching Phase III trials of REGN-COV2, the company’s two-antibody cocktail for the treatment and prevention of COVID-19. Today, it announced that it had received a $450 million contract to manufacture and supply the antibody cocktail as part of Operation Warp Speed from the Biomedical Advanced Research and Development Authority (BARDA).

BARDA is part of the Office of the Assistant Secretary for Preparedness and Response at the U.S. Department of Health and Human Services. The contract was also with the Department of Defense Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense.

A Phase I trial in 30 hospitalized and non-hospitalized patients with COVID-19 received a positive review from the Independent Data Monitoring Committee.

Continue reading “Regeneron Receives $450 Million BARDA Contract for COVID-19 Antibody Cocktail” »

San Jose State’s Claire Komives is testing an antivenom inspired by opossum biochemistry against various snake species to prevent deaths in the developing world.

Magnetically separating waste particles makes it possible to reclaim a variety of raw materials from waste. Using a magnetic fluid, a waste flow can be separated into multiple segments in a single step. Researchers from Utrecht and Nijmegen have now succeeded in creating a magnetic fluid that remains stable in extremely strong magnetic fields, which makes it possible to separate materials with a high density, such as electronic components. The results have recently been published in The Journal of Physical Chemistry Letters.

Magnetic density separation

When you drop a stone and a wooden ball into a basin of water, the stone will sink while the ball floats on the surface. This is because the two objects have different densities: the stone is more dense than the water, while the wood is less dense. That principle is also used in magnetic density separation (MDS), except that instead of using water—which has a fixed density—it uses a magnetic fluid with an effective density that can change in relation to its distance from a magnet: it has a higher apparent density at less distance to the magnet. As a result, waste particles of different densities float at different depths in the fluid.

The latest AI algorithms are probing the evolution of galaxies, calculating quantum wave functions, discovering new chemical compounds and more. Is there anything that scientists do that can’t be automated?

The researchers used powerful laser flashes to irradiate thin, films of crystalline materials. These laser pulses drove crystal electrons into a fast wiggling motion. As the electrons bounced off with the surrounding electrons, they emitted radiation in the extreme ultraviolet part of the spectrum. By analyzing the properties of this radiation, the researchers composed pictures that illustrate how the electron cloud is distributed among atoms in the crystal lattice of solids with a resolution of a few tens of picometers which is a billionth of a millimeter.

The experiments pave the way towards developing a new class of laser-based microscopes that could allow physicists, chemists, and material scientists to peer into the details of the microcosm with unprecedented resolution and to deeply understand and eventually control the chemical and the electronic properties of materials.

For decades scientists have used flashes of laser light to understand the inner workings of the microcosm. Such lasers flashes can now track ultrafast microscopic processes inside solids. Still they cannot spatially resolve electrons, that is, to see how electrons occupy the minute space among atoms in crystals, and how they form the chemical bonds that hold atoms together. The reason is long known. It was discovered by Abbe more than a century back. Visible light can only discern objects commensurable in size to its wavelength which is approximately few hundreds of nanometers. But to see electrons, the microscopes have to increase their magnification power by a few thousand times.