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Category: chemistry – Page 3

Commercially viable biomanufacturing: Designer yeast turns sugar into lucrative chemical 3-HP

Using a tiny, acid-tolerant yeast, scientists have demonstrated a cost-effective way to make disposable diapers, microplastics, and acrylic paint more sustainable through biomanufacturing.

A key ingredient in those everyday products is acrylic acid, an important industrial chemical that gives disposable diapers their absorbency, makes water-based paints and sealants more weather-proof, improves stain resistance in fabric, and enhances fertilizers and soil treatments.

Acrylic acid is converted from a precursor called 3-hydroxypropanoic acid, or 3-HP, which is made almost exclusively from petroleum through chemical synthesis—an energy-intensive process. But 3-HP can also be produced from renewable plant material by using engineered microbes to ferment plant sugars into this high-value chemical. Until now, however, the biomanufacturing process has not proven profitable.

Advances in thin-film electrolytes push solid oxide fuel cells forward

Under the threat of climate change and geopolitical tensions related to fossil fuels, the world faces an urgent need to find sustainable and renewable energy solutions. While wind, solar, and hydroelectric power are key renewable energy sources, their output strongly depends on environmental conditions, meaning they are unable to provide a stable electricity supply for modern grids.

Solid oxide fuel cells (SOFCs), on the other hand, represent a promising alternative; these devices produce electricity on demand directly from clean electrochemical reactions involving hydrogen and oxygen.

However, existing SOFC designs still face technical limitations that hinder their widespread adoption for power generation. SOFCs typically rely on bulk ceramic electrolytes and require high operating temperatures, ranging from 600–1,000 °C. This excessive heat not only forces manufacturers to use expensive, high-performance materials, but also leads to earlier component degradation, limiting the cell’s service life and driving up costs.

Radiotracers could improve choice of bladder cancer therapies

A research team at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) has developed a radiopharmaceutical molecule marker that can visualize tumors that carry the cell surface protein Nectin-4. This primarily occurs in the body in cases of urothelial carcinoma, a common form of bladder cancer.

In pre-clinical trials, the drug candidate, NECT-224, proved stable and was successfully used in humans for the first time. As the team has now reported in the Journal of Medicinal Chemistry, in the future, it could be used to better identify patients who would benefit from Nectin-4-targeted therapies.

Many modern cancer drugs only work when the target structure to which they are supposed to bind is also present on the tumor cells. In the case of urothelial carcinoma, the cell surface protein Nectin-4 lends itself to this purpose. It serves as a “door sign” for antibody-coupled agents that are able to eliminate tumor cells in a targeted fashion. But not every tumor produces the same amount of Nectin-4.

OLED lighting: Corrugated panel design extends longevity and efficiency

The organic light emitting diodes—known widely as OLEDs—that create vibrant smartphone displays could illuminate rooms, but current designs burn out too quickly at the high brightness needed for room lighting. A new approach overcomes this tradeoff by building OLEDs on a corrugated surface, packing more emitting material into a given lighting panel area to produce the same amount of light while operating the OLED itself at lower brightness.

This corrugated panel strategy increased device lifespan by a factor of 2.7 compared to flat panels operated at the same current, according to a study led by the University of Michigan in collaboration with OLEDWorks and The Pennsylvania State University.

“While the problems we solved along the way were daunting, in the end the new device performed tremendously better than predecessors. It’s rewarding to see our ideas point towards a valid path to improve the efficiency and lifetime of OLED lighting,” said Max Shtein, a professor of materials science and engineering and chemical engineering at U-M and co-corresponding author of the study published in Nature Communications.

Entanglement enhances the speed of quantum simulations, transforming long-standing obstacles into a powerful advantage

Researchers from the Faculty of Engineering at The University of Hong Kong (HKU) have made a significant discovery regarding quantum entanglement. This phenomenon, which has long been viewed as a significant obstacle in classical quantum simulations, actually enhances the speed of quantum simulations. The findings are published in Nature Physics in an article titled “Entanglement accelerates quantum simulation.”

Simulating the dynamic evolution of matter is fundamental to understanding the universe, yet it remains one of the most challenging tasks in physics and chemistry. For decades, “entanglement”—the complex correlation between quantum particles—has been viewed as a formidable barrier. In classical computing, high entanglement makes simulations exponentially harder to perform, often acting as a bottleneck for studying complex quantum systems.

Led by Professor Qi Zhao from the School of Computing and Data Science at HKU, the research team collaborated with Professor You Zhou from Fudan University and Professor Andrew M. Childs from the University of Maryland, and overturned this long-held belief. They discovered that while entanglement hinders classical computers, it actually accelerates quantum simulations, turning a former obstacle into a powerful resource.

Sensor lights up to reveal scopolamine, a common substance used for sexual assault

A team from the Universitat Politècnica de València (UPV) has led the development of a new sensor capable of quickly and easily detecting scopolamine, one of the substances most commonly used in crimes of chemical submission, especially in sexual assaults. The sensor detects the presence of this drug in less than five minutes with high sensitivity. The research is published in the journal Angewandte Chemie International Edition.

“Scopolamine is a substance that is difficult to detect using conventional methods, especially when found in drinks. For this reason, our group from the IDM Institute at the UPV set out to develop new, simple tools that can immediately alert us to its presence,” says Vicente Martí Centelles, a researcher at the Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) at the UPV.

The electrifying science behind Martian dust

Mars, often depicted as a barren red planet, is far from lifeless. With its thin atmosphere and dusty surface, it is an energetic and electrically charged environment where dust storms and dust devils continually reshape the landscape, creating dynamic processes that have intrigued scientists.

Planetary scientist Alian Wang has been shedding light on Mars’s electrifying dust activities through a series of papers. Her latest research, published in Earth and Planetary Science Letters, explores the isotopic geochemical consequences of these activities.

New evidence for a particle system that ‘remembers’ its previous quantum states

In the future, quantum computers are anticipated to solve problems once thought unsolvable, from predicting the course of chemical reactions to producing highly reliable weather forecasts. For now, however, they remain extremely sensitive to environmental disturbances and prone to information loss.

A new study from the lab of Dr. Yuval Ronen at the Weizmann Institute of Science, published in Nature, presents fresh evidence for the existence of non-Abelian anyons—exotic particles considered prime candidates for building a fault-tolerant quantum computer. This evidence was produced within bilayer graphene, an ultrathin carbon crystal with unusual electronic behavior.

In quantum mechanics, particles also behave like waves, and their properties are described by a wave function, which can represent the state of a single particle or a system of particles. Physicists classify particles according to how the wave function of two identical particles changes when they exchange places. Until the 1980s, only two types of particles were known: bosons (such as photons), whose wave function remains unchanged when they exchange places, and fermions (such as electrons), whose wave function becomes inverted.

THz spectroscopy system bypasses long-standing tradeoff between spectral and spatial resolution

Terahertz (THz) radiation, which occupies the frequency band between microwaves and infrared light, is essential in many next-generation applications, including high-speed wireless communications, chemical sensing, and advanced material analysis.

To harness THz waves, scientists rely on functional devices like metasurfaces and resonant gratings, which exhibit sharp and effective resonance features. Characterizing and optimizing these high-performance devices, however, remains a technical challenge.

The difficulty stems from a fundamental tradeoff when performing THz measurements: achieving high spectral resolution versus high spatial resolution. To accurately capture the narrow spectral fingerprints of certain gases and the features of devices with a high quality factor (Q), researchers need very high spectral resolution.

Potential Anti-Cancer Fungal Compound Finally Synthesized After 55 Years

The fungal compound verticillin A, discovered more than 50 years ago, has long been regarded for its potential cancer-fighting capabilities. S cientists have now managed to artificially synthesize the compound for the first time, meaning they can study it in more detail and potentially develop new cancer treatments.

Being able to produce verticillin A on demand in the lab is a major step forward. In nature, it’s found only in small amounts in a microscopic fungus and is very difficult to extract.

Before now, the complex chemical structure and inherent instability of verticillin A made it tricky to synthesize, but researchers from MIT and Harvard Medical School have overcome both problems.

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