Lifeboat Foundation

Can weight loss leave a lasting imprint on our fat cells?

Losing weight is often touted as a cornerstone of better health, particularly for people dealing with obesity and its associated health risks.

Anyone who has ever tried to get rid of a few extra kilos knows the frustration: the weight drops initially, only to be back within a matter of weeks—the yo-yo effect has struck. Researchers at ETH Zurich have now been able to show that this is all down to epigenetics.

Continue reading “Fat cells have epigenetics-based memory: Researchers discover mechanism behind weight loss yo-yo effect” »

Researchers in the Nanoscience Center at the University of Jyväskylä, Finland, have used machine learning and supercomputer simulations to investigate how tiny gold nanoparticles bind to blood proteins. The studies discovered that favorable nanoparticle-protein interactions can be predicted from machine learning models that are trained from atom-scale molecular dynamics simulations. The new methodology opens ways to simulate the efficacy of gold nanoparticles as targeted drug delivery systems in precision nanomedicine.

Hybrid nanostructures between biomolecules and inorganic nanomaterials constitute a largely unexplored field of research, with the potential for novel applications in bioimaging, biosensing, and nanomedicine. Developing such applications relies critically on understanding the dynamical properties of the nano–bio interface.

Modeling the properties of the nano-bio interface is demanding since the important processes such as electronic charge transfer, chemical reactions or restructuring of the biomolecule surface can take place in a wide range of length and time scales, and the atomistic simulations need to be run in the appropriate aqueous environment.

Researchers from the University of Bonn have trained an AI process to predict potential active ingredients with special properties. Therefore, they derived a chemical language model — a kind of ChatGPT for molecules. Following a training phase, the AI was able to exactly reproduce the chemical structures of compounds with known dual-target activity that may be particularly effective medications. The study has now been published in Cell Reports Physical Science.

Anyone who wants to delight their granny with a poem on her 90th birthday doesn’t need to be a poet nowadays: A short prompt in ChatGPT is all it takes, and within a few seconds the AI spits out a long list of words that rhyme with the birthday girl’s name. It can even produce a sonnet to go with it if you like.

Researchers at the University of Bonn have implemented a similar model in their study — known as a chemical language model. This does not, however, produce rhymes. Instead, the AI displays the structural formulas of chemical compounds that may have a particularly desirable property: They are able to bind to two different target proteins. In the organism, this means, for example, they can inhibit two enzymes at once.

Water, a molecule essential for life, exhibits unusual properties—referred to as anomalies—that define its behavior. Despite extensive study, many mysteries remain about the molecular mechanisms underlying these anomalies that make water unique. Deciphering and replicating this distinctive behavior across various temperature ranges remains a significant challenge for the scientific community.

Now, a study presents a new theoretical model capable of overcoming the limitations of previous methodologies to understand how water behaves in extreme conditions. The paper, featured on the cover of The Journal of Chemical Physics, is led by Giancarlo Franzese and Luis Enrique Coronas, from the Faculty of Physics and the Institute of Nanoscience and Nanotechnology of the University of Barcelona (IN2UB).

The study not only broadens our understanding of the physics of water, but also has implications for technology, biology and biomedicine, in particular for addressing the treatment of neurodegenerative diseases and the development of advanced biotechnologies.

A research team led by Dr. Hyung-Suk Oh and Dr. Woong Hee Lee at the Clean Energy Research Center at Korea Institute of Science and Technology (KIST) has developed a silver-silica composite catalyst capable of reversible local pH control through a silica-hydroxide cycle, inspired by Earth’s natural cycles.

Scientists have found that a process called neurotransmitter switching—where neurons alter their chemical signals—plays a role in the development of autism-related traits.

YORKTOWN HEIGHTS, N.Y., Nov. 13, 2024 /PRNewswire/ — Today at its inaugural IBM Quantum Developer Conference, IBM (NYSE: IBM) announced quantum hardware and software advancements to execute complex algorithms on IBM quantum computers with record levels of scale, speed, and accuracy.

IBM Quantum Heron, the company’s most performant quantum processor to-date and available in IBM’s global quantum data centers, can now leverage Qiskit to accurately run certain classes of quantum circuits with up to 5,000 two-qubit gate operations. Users can now use these capabilities to expand explorations in how quantum computers can tackle scientific problems across materials, chemistry, life sciences, high-energy physics, and more.

A research team reports in the journal Angewandte Chemie that gamma radiation can transform methane into a diverse range of products at room temperature, including hydrocarbons, oxygenated molecules, and amino acids. This reaction likely plays a significant role in the formation of complex organic molecules in the universe—and may even contribute to the origins of life. Additionally, it presents new opportunities for industrially converting methane into high-value products under mild conditions.

With these research results, the team led by Weixin Huang at the University of Science and Technology of China (Hefei) has contributed to our fundamental understanding of the early development of molecules in the universe.

“Gamma rays, high-energy photons commonly existing in cosmic rays and unstable isotope decay, provide external energy to drive chemical reactions of simple molecules in the icy mantles of interstellar dust and ice grains,” states Huang. “This can result in more complex organic molecules, presumably starting from methane (CH₄), which is widely present throughout the interstellar medium.”

This study explores how muscle contractions, such as those that occur during exercise, influence motor neurons—the cells responsible for controlling muscle movement.

There’s no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.

Now, MIT engineers have found that exercise can also have benefits at the level of individual neurons. They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines.

Continue reading “When muscles work out, they help neurons grow: Biochemical and physical effects of exercise could help heal nerves” »