Lifeboat Foundation

Artificial flesh is growing ever closer to the real thing. Scientists in Australia have now created a new jelly-like material which they claim has the strength and durability of actual skin, ligaments, or even bone.

“With the special chemistry we’ve engineered in the hydrogel, it can repair itself after it has been broken like human skin can,” explains chemist Luke Connal from the Australian National University.

“Hydrogels are usually weak, but our material is so strong it could easily lift very heavy objects and can change its shape like human muscles do.”

Determining the quantum mechanical behavior of many interacting particles is essential to solving important problems in a variety of scientific fields, including physics, chemistry and mathematics. For instance, in order to describe the electronic structure of materials and molecules, researchers first need to find the ground, excited and thermal states of the Born-Oppenheimer Hamiltonian approximation. In quantum chemistry, the Born-Oppenheimer approximation is the assumption that electronic and nuclear motions in molecules can be separated.

A variety of other scientific problems also require the accurate computation of Hamiltonian ground, excited and thermal states on a quantum computer. An important example are combinatorial optimization problems, which can be reduced to finding the ground state of suitable spin systems.

So far, techniques for computing Hamiltonian eigenstates on quantum computers have been primarily based on phase estimation or variational algorithms, which are designed to approximate the lowest energy eigenstate (i.e., ground state) and a number of excited states. Unfortunately, these techniques can have significant disadvantages, which make them impracticable for solving many scientific problems.

The coldest chemical reaction in the known universe took place in what appears to be a chaotic mess of lasers. The appearance deceives: Deep within that painstakingly organized chaos, in temperatures millions of times colder than interstellar space, Kang-Kuen Ni achieved a feat of precision. Forcing two ultracold molecules to meet and react, she broke and formed the coldest bonds in the history of molecular couplings.

“Probably in the next couple of years, we are the only lab that can do this,” said Ming-Guang Hu, a postdoctoral scholar in the Ni lab and first author on their paper published today in Science. Five years ago, Ni, the Morris Kahn Associate Professor of Chemistry and Chemical Biology and a pioneer of ultracold chemistry, set out to build a new apparatus that could achieve the lowest temperature chemical reactions of any currently available technology. But they couldn’t be sure their intricate engineering would work.

Now, they not only performed the coldest reaction yet, they discovered their new apparatus can do something even they did not predict. In such intense cold—500 nanokelvin or just a few millionths of a degree above absolute zero—their molecules slowed to such glacial speeds, Ni and her team could see something no one has been able to see before: the moment when two molecules meet to form two new molecules. In essence, they captured a chemical reaction in its most critical and elusive act.

Last week, the BBC reported on the plight of axolotls in Mexico City, which are under threat of extinction. [1] The risk to these creatures is made doubly concerning when you consider their incredible ability to regenerate and apparent immunity to cancer, which is of great interest to scientists and companies working in the Longevity sector. One such company is Bioquark, a Philadelphia-based life sciences company that is working on the development of combinatorial biologics for the rejuvenation and repair of human organs and tissues. Among its clinical plans, it lists the development of therapeutic products for cancer reversion, organ repair and regeneration, and even brain death resuscitation. Nothing major then!

Bioquark has developed a novel combinatorial biologic called BQ-A, which mimics the regulatory biochemistry of the living human egg (oocyte) immediately following fertilization. While ooplasm-based reprogramming has been studied in experiments such as in-vitro fertilization and cloning, Bioquark claims it is the first company to apply it to somatic tissue in mammals.

We spoke with Bioquark’s CEO, Ira Pastor, a 30-year veteran of the pharmaceutical industry, to find out more about the company and where it’s headed.

Scientists have discovered a way to manipulate the body’s own immune response to boost tissue repair. The findings, published in Current Biology today, reveal a new network of protective factors to shield cells against damage. This discovery, made by University of Bristol researchers, could significantly benefit patients undergoing surgery by speeding recovery times and lowering the risk of complication.

When a tissue is damaged, (either accidentally or through surgery), the body quickly recruits immune cells to the injury site where they fight infection by engulfing and killing invading pathogens, through the release of toxic factors (such as unstable molecules containing oxygen known as “reactive oxygen species” e.g. peroxides). However, these bactericidal products are also highly toxic to the host tissue and can disrupt the repair process. To counteract these harmful effects the repairing tissue activates powerful protective machinery to “shield” itself from the damage.

Now, researchers from Bristol’s School of Biochemistry studying tissue repair, have mapped the exact identities of these protective pathways and identified how to stimulate this process in naïve tissues.

Artificial intelligence can be used to predict molecular wave functions and the electronic properties of molecules. This innovative AI method developed by a team of researchers at the University of Warwick, the Technical University of Berlin and the University of Luxembourg, could be used to speed-up the design of drug molecules or new materials.

Artificial intelligence and machine learning algorithms are routinely used to predict our purchasing behavior and to recognize our faces or handwriting. In scientific research, Artificial Intelligence is establishing itself as a crucial tool for scientific discovery.

In chemistry, AI has become instrumental in predicting the outcomes of experiments or simulations of quantum systems. To achieve this, AI needs to be able to systematically incorporate the fundamental laws of physics.