Lifeboat Foundation

“Mikhail first approached me nearly 15 years ago with the totally crazy idea that replacing hydrogen with deuterium in bioactive molecules so as to slow down undesirable chemical reactions. Well, if ever there were a proof that some of the craziest ideas are actually right, it is this one. In the years since, Misha and his company Retrotope have taken this concept from chemistry to yeast to mice and all the way to highly promising clinical results for several hitherto untreatable orphan diseases. I’m looking forward to hearing the latest!” says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-mikhail-s-shchepinov-t…aging-2019

#undoingaging #sens #foreverhealthy

The paper is the latest in a series demonstrating the ability to use a dirhodium catalyst to selectively functionalize C-H bonds in a streamlined manner, while also maintaining virtually full control of the three-dimensional shape of the molecules produced.

“This latest catalyst is so selective that it goes cleanly for just one C-H bond—even though there are several C-H bonds very similar to it within the molecule,” says senior author Huw Davies, professor of organic chemistry. “That was a huge surprise, even to us.”

This dirhodium catalyst works on a substrate of tert-butyl cyclohexane, a hydrocarbon—one of the simplest of organic molecules, consisting entirely of C-H bonds.

New program coming on-line at Bioquark Inc. (www.bioquark.com) — Ectocrine interactions (the“Ectocrinome”) represents a completely unexplored area related to human health

https://www.prweb.com/releases/bioquark_inc_and_ectocrine_te…004155.htm

An international team of physicists and materials scientists from NUST MISIS, Bayerisches Geoinstitut (Germany), Linkoping University (Sweden), and the California Institute of Technology (U.S.) has discovered an “impossible” modification of silica-coesite-IV and coasite-V materials, which seems to defy the generally accepted rules for the formation of chemical bonds in inorganic materials formulated by Linus Pauling, who won the 1954 Nobel Prize in Chemistry for that discovery. The research results were published in Nature Communications on November 15th, 2018.

According to Pauling’s rules, the fragments of the atomic lattice in inorganic materials are connected by vertices, because bonding by faces is the most energy-intensive way to form a chemical connection. Therefore, it does not exist in nature. However, scientists have proved, both experimentally and theoretically, using NUST MISIS’ supercomputer, that it is possible to form such a connections if the materials are at ultra-high pressure conditions. The obtained results show that fundamentally new classes of materials exist at extreme conditions.

“In our work, we have synthesized and described metastable phases of high-pressure silica: coesite-IV and coesite-V. Their crystal structures are drastically different from any of the earlier described models,” says Igor Abrikosov, leader of the theoretical research team. “Two newly discovered coesites contain octahedrons SiO₆, that, contrary to Pauling’s rule, are connected through common face, which is the most energy-intensive chemical connection. Our results show that the possible silicate magmas in the lower mantle of the Earth can have complex structures, which makes these magmas more compressible than predicted before.”

Continue reading “Silica paradox: Scientists discover seemingly ‘impossible’ material” »

The team combines 1,200 scientists from 52 countries in disciplines ranging from geology and microbiology to chemistry and physics. A year before the conclusion of their 10-year study, they will present an amalgamation of findings to date before the American Geophysical Union’s annual meeting opens this week.

Global team of scientists find ecosystem below earth that is twice the size of world’s oceans.

We thought we knew everything about carbon. We were wrong.

If classic monster movies and old science experiments are to be believed, life begins with a spark.

Not everybody is convinced by this kind of origin story, so the search continues for sources of energy capable of transforming a prebiotic soup into a life-generating dish. Maybe the secret ingredient isn’t anything more shocking than a pinch of salt.

A new study led by researchers from the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology in Japan has turned their attention to common old sodium chloride as a potential conduit for the chemical energy required for early biochemistry.

Continue reading “Life on Earth Could Have Started Thanks to a Simple Ingredient We Use Every Day” »

QUT chemistry researchers have discovered cheaper and more efficient materials for producing hydrogen for the storage of renewable energy that could replace current water-splitting catalysts.

Professor Anthony O’Mullane said the potential for the chemical storage of renewable energy in the form of hydrogen was being investigated around the world.

Continue reading “New catalyst material produces abundant cheap hydrogen” »

The periodic table is chemistry’s holy text. Not only does it list all of the tools at chemists’ disposal, but its mere shape—where these elements fall into specific rows and columns—has made profound predictions about new elements and their properties that later came true. But few chemists on Earth have a closer relationship with the document than Dawn Shaughnessy, whose team is partially responsible for adding six new elements to table’s ranks.

Shaughnessy leads a team of real-life alchemists. You might be familiar with alchemy as a medieval European practice where mystics attempted to transmute elements into more valuable ones. But rather than turn the element lead into gold, Shaughnessy and her team turned plutonium into flerovium.

Shaughnessy’s parents encouraged her to pursue science from a young age—her father was an engineer, and she had an electronics kit as well as a chemistry set as a child. She’d first thought about doing orthopedic research but didn’t want to cut people open, she explained to me, and chemistry was a natural fit. But when she arrived at the University of California, Berkeley as an undergraduate, she learned that chemistry could be more than just mixing liquids in beakers. She could create the atoms themselves.

Continue reading “Meet Dawn Shaughnessy, the Real-Life Alchemist Who Expanded the Periodic Table” »