Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: chemistry – Page 332

Bacteria Reprogrammed to Make Designer Molecule Used in Pharmaceutical Drugs

Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published on March 22021, in Nature Communications, the researchers modified E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.

Genetically engineered E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules — called sulfated glycosaminoglycans — that are often used as drugs and nutraceuticals…

“It’s a challenge to engineer E. coli to produce these molecules, and we had to make many changes and balance those changes so that the bacteria will grow well,” said Mattheos Koffas, lead researcher and a professor of chemical and biological engineering at Rensselaer Polytechnic Institute. “But this work shows that it is possible to produce these polysaccharides using E. coli in animal-free fashion, and the procedure can be extended to produce other sulfated glycosaminoglycans.”

Twistoptics: A New, Efficient Way to Control Optical Nonlinearity

Columbia researchers engineer first technique to exploit the tunable symmetry of 2D materials for nonlinear optical applications, including laser, optical spectroscopy, imaging, and metrology systems, as well as next-generation optical quantum information processing and computing.

Nonlinear optics, a study of how light interacts with matter, is critical to many photonic applications, from the green laser pointers we’re all familiar with to intense broadband (white) light sources for quantum photonics that enable optical quantum computing, super-resolution imaging, optical sensing and ranging, and more. Through nonlinear optics, researchers are discovering new ways to use light, from getting a closer look at ultrafast processes in physics, biology, and chemistry to enhancing communication and navigation, solar energy harvesting, medical testing, and cybersecurity.

Columbia Engineering researchers report that they developed a new, efficient way to modulate and enhance an important type of nonlinear optical process: optical second harmonic generation — where two input photons are combined in the material to produce one photon with twice the energy — from hexagonal boron nitride through micromechanical rotation and multilayer stacking. The study was published online on March 32021, by Science Advances.

Stamp-Sized Patch Can Check Your Sugar, Caffeine, Alcohol, and Blood Pressure Levels

Researchers at the University of California San Diego (UCSD) have developed a wearable health monitor that may bring us one step closer to the dream of Star Trek’s famous tricorder.

The monitor, a stretchy skin patch, can do it all: measuring blood pressure and heart rate, your glucose levels, as well as one of alcohol, caffeine, or lactate levels.

According to UCSD’s press release, the patch is the first device to demonstrate measuring multiple biochemical and cardiovascular signals at the same time.

New Research Reveals That Quantum Physics Causes Mutations in Our DNA

An innovative study has confirmed that quantum mechanics plays a role in biological processes and causes mutations in DNA.

Quantum biology is an emerging field of science, established in the 1920s, which looks at whether the subatomic world of quantum mechanics plays a role in living cells. Quantum mechanics is an interdisciplinary field by nature, bringing together nuclear physicists, biochemists and molecular biologists.

In a research paper published by the journal Physical Chemistry Chemical Physics, a team from Surrey’s Leverhulme Quantum Biology Doctoral Training Centre used state-of-the-art computer simulations and quantum mechanical methods to determine the role proton tunneling, a purely quantum phenomenon, plays in spontaneous mutations inside DNA.

Dr. Ellen de Brabander — SVP, R&D, PepsiCo — The Future Of Food And Beverage Innovation

The Future Of Food And Beverage Innovation And Venturing — Dr. Ellen De Brabander, Ph.D. — Senior Vice President, R&D, PepsiCo

Dr. Ellen de Brabander, is Senior Vice President, Research and Development, at PepsiCo, the American multinational food, snack, and beverage company.

Dr. de Brabander has broad set of responsibilities at Pepsico and currently leads their global R&D functions including the Food Safety, Quality, Strategy & Portfolio Management, and their Sensory and Regulatory Affairs teams. She also leads their R&D Digital Transformation initiatives to transform the innovation process to bring new, innovative products to the market.

Dr. de Brabander is also a member of the board of governors at the New York Academy of Sciences and has served as Treasurer and board member International Life Science Institute of North America, an organization that brings together scientists from government, academia and industry to uphold the scientific integrity and objectivity of nutrition and food safety science in order to ethically improve food systems for the betterment of public health.

Additionally, Dr. de Brabander has also served as the interim and founding CEO of EIT Food (part of the EU’s European Institute of Innovation and Technology), which is a unique $1.5 Billion Euro innovation consortium with more than 50 partners from industry and academia, focused on transforming the food sector by designing and delivering unique and high impact research, innovation, business creation and education programs.

Continue reading “Dr. Ellen de Brabander — SVP, R&D, PepsiCo — The Future Of Food And Beverage Innovation” | >

Breakthrough greatly enhances ultrafast resolution achievable with X-ray free-electron lasers

A large international team of scientists from various research organizations, including the U.S. Department of Energy’s (DOE) Argonne National Laboratory, has developed a method that dramatically improves the already ultrafast time resolution achievable with X-ray free-electron lasers (XFELs). It could lead to breakthroughs on how to design new materials and more efficient chemical processes.

Detecting multiple sepsis biomarkers from whole blood – made fast, accurate, and cheap

The Wyss Institute’s eRapid electrochemical sensor technology now enables sensitive, specific and multiplexed detection of blood biomarkers at low cost with potential for many clinical applications.

Multimedia Available

The Wyss Institute for Biologically Inspired Engineering at Harvard University (http://wyss.harvard.edu) uses Nature’s design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing that are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and formation of new startups. The Wyss Institute creates transformative technological breakthroughs by engaging in high risk research, and crosses disciplinary and institutional barriers, working as an alliance that includes Harvard’s Schools of Medicine, Engineering, Arts & Sciences and Design, and in partnership with Beth Israel Deaconess Medical Center, Brigham and Women’s Hospital, Boston Children’s Hospital, Dana–Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Boston University, Tufts University, Charité – Universitätsmedizin Berlin, University of Zurich and Massachusetts Institute of Technology.

Dr. John S Torday — Lundquist Institute / UCLA — Aging And Disease As A Process Of Reverse Evolution

Dr. John Torday, Ph.D. is an Investigator at The Lundquist Institute of Biomedical Innovation, a Professor of Pediatrics and Obstetrics/Gynecology, and Faculty, Evolutionary Medicine, at the David Geffen School of Medicine at UCLA, and Director of the Perinatal Research Training Program, the Guenther Laboratory for Cell-Molecular Biology, and Faculty in the Division of Neonatology, at Harbor-UCLA Medical Center.

Dr. Torday studies the cellular-molecular development of the lung and other visceral organs, and using the well-established principles of cell-cell communication as the basis for determining the patterns of physiologic development, his laboratory was the first to determine the complete repertoire of lung alveolar morphogenesis. This highly regulated structure offered the opportunity to trace the evolution of the lung from its unicellular origins forward, developmentally and phylogenetically. The lung is an algorithm for understanding the evolution of other physiologic properties, such as in the kidney, skin, liver, gut, and central nervous system. Such basic knowledge of the how and why of physiologic evolution is useful in the effective diagnosis and treatment of disease.

Dr. Torday received his undergraduate degree in Biology and English from Boston University, and his MSc and PhD in Experimental Medicine from McGill University, Montreal, Canada. He did a post-doctoral Fellowship in Reproductive Endocrinology at the University of Wisconsin-Madison, WI.

Dr. Torday’s research has led to the publication of more than 150 peer-reviewed articles and 350 abstracts. More recently, he has gained an interest in the evolutionary aspects of comparative physiology and development, leading to the publication of 12 peer-reviewed articles on the cellular origins of vertebrate physiology, culminating in the book Evolutionary Biology, Cell-Cell Communication and Complex Disease.

Dr. Torday is also the co-author / co-editor on several volumes including: Evolution, the Logic of Biology, Evidence-Based Evolutionary Medicine, Morphogenesis, Environmental Stress and Reverse Evolution, and most recently, The Singularity of Nature: A Convergence of Biology, Chemistry and Physics.

Toward the development of drugs for aging-related diseases

In the search for ways to effectively combat age-related human disease, the enzyme sirtuin 6 (Sirt6) has recently become a focus of biochemical research. A targeted activation of Sirt6 could prevent or mitigate such diseases, for example some types of cancer. In a paper for the journal Nature Chemical Biology, biochemists from the University of Bayreuth have now shown how the small molecule MDL-801 binds to the enzyme Sirt6 and influences its activity. These findings stand to aid the development of new drugs.

Interesting pattern in cross-sections observed in F + HD → HF + D reaction

A team of researchers from the University of Science and Technology of China, the Chinese Academy of Sciences and the Southern University of Science and Technology, has discovered a thought-provoking pattern in cross-sections observed in an F + HD → HF + D reaction. In their paper published in the journal Science, the group describes their double-pronged approach to learning more about the role of relativistic spin-orbit interactions in chemical reactions. T. Peter Rakitzis, with the University of Crete, and IESL-FORTH, has published a Perspectives piece in the same journal issue outlining the difficulty of studying chemical reactions at the quantum level and the work done by the team in China.