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Oral immunotherapy shrinks gastrointestinal tumors in mouse study.

Immunotherapy is a promising treatment that recruits the immune system to help fight cancer, but it has had limited success in gastrointestinal cancers. Now, researchers at Washington University School of Medicine in St. Louis have engineered a probiotic that delivers immunotherapy directly to the gut to shrink tumors in mice, offering a potentially promising oral drug for hard-to-reach cancers.

The probiotic cancer treatment, described Nov. 20 in the journal Cell Chemical Biology, establishes a customizable drug delivery system that can be modified to potentially treat other gut diseases.

The findings suggest that biochemical and physical effects of exercise could help heal nerves. There’s no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.

Now, MIT engineers have found that exercise can also have benefits at the level of individual neurons. They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines. In the presence of these muscle-generated signals, neurons grew 4X farther compared to neurons that were not exposed to myokines. These cellular-level experiments suggest that exercise can have a significant biochemical effect on nerve growth.

Surprisingly, the researchers also found that neurons respond not only to the biochemical signals of exercise but also to its physical impacts. The team observed that when neurons are repeatedly pulled back and forth, similarly to how muscles contract and expand during exercise, the neurons grow just as much as when they are exposed to a muscle’s myokines.

Pervasive micropollutants in aquatic environments pose significant threats to global water supply safety. Here, authors achieved permeate concentrations below the detection limit (2.5 ng/L) using a CNT-based electrochemical membrane, with the contributions of adsorption and degradation distinguished.

The reliable control of traveling waves emerging from the coupling of oscillations and diffusion in physical, chemical and biological systems is a long-standing challenge within the physics community. Effective approaches to control these waves help to improve the present understanding of reaction-diffusion systems and their underlying dynamics.

Researchers at Université libre de Bruxelles (ULB) and Université de Rennes recently demonstrated a promising approach to control chemical waves in a type of fluid flow known as hyperbolic flow. Their experimental methods, outlined in Physical Review Letters recently, entail the control of chemical waves via the stretching and compression of fluids.

“At a summer school in Corsica, discussions between the Brussels and Rennes team triggered the curiosity to see how chemical waves studied at ULB in Brussels would behave in hyperbolic flows analyzed in Rennes,” Anne De Wit, senior author of the paper, told Phys.org. “The primary objective was to see how a non-trivial flow would influence the dynamics of waves.”

Boosting the endocannabinoid 2-AG in the brain can counteract opioid addiction while preserving their pain relief, a Weill Cornell Medicine study finds. This approach, tested in mice using the chemical JZL184, may lead to safer treatments for pain management.

The natural enhancement of chemicals produced by the body, known as endocannabinoids, may mitigate the addictive properties of opioids like morphine and oxycodone while preserving their pain-relieving effects, according to researchers from Weill Cornell Medicine in collaboration with The Center for Youth Mental Health at NewYork-Presbyterian. Endocannabinoids interact with cannabinoid receptors found throughout the body, which play a role in regulating functions such as learning and memory, emotions, sleep, immune response, and appetite.

Opioids prescribed to control pain can become addictive because they not only dull pain, but also produce a sense of euphoria. The preclinical study, published recently in the journal Science Advances, may lead to a new type of therapeutic that could be taken with an opioid regimen to only reduce the reward aspect of opioids.

Researchers have developed a new laser technology using large colloidal quantum dots of lead sulfide to emit coherent light in the extended short-wave infrared range.

This innovation promises cheaper, scalable laser solutions compatible with silicon CMOS platforms, covering a broader wavelength range without altering chemical compositions, and eliminating the need for costly femtosecond laser amplifiers.

Novel Laser Technologies

The researchers produced new materials with perovskite crystal structures and compared them with existing materials at the cell level, concluding that high efficiencies can only be achieved with lead perovskites. They then fabricated highly efficient demonstrators, such as a perovskite silicon tandem solar cell of more than 100 sq cm with screen-printed metallization.

The project also included the development of a scalable perovskite-silicon tandem solar cell that achieved a 31.6% power conversion efficiency, first announced in September. The Fraunhofer researchers used a combination of vapor deposition and wet-chemical deposition to ensure an even deposition of the perovskite layer on the textured silicon surface. “Close industrial cooperation is the next step in establishing this future technology in Europe,” said Professor Andreas Bett, coordinator of the project.

Photosynthesis is one of the most efficient natural processes for converting light energy from the sun into chemical energy vital for life on earth. Proteins called photosystems are critical to this process and are responsible for the conversion of light energy to chemical energy.

Combining one kind of these proteins, called photosystem I (PSI), with platinum nanoparticles, microscopic particles that can perform a chemical reaction that produces hydrogen — a valuable clean energy source — creates a biohybrid catalyst. That is, the light absorbed by PSI drives hydrogen production by the platinum nanoparticle.

In a recent breakthrough, researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory and Yale University have determined the structure of the PSI biohybrid solar fuel catalyst. Building on more than 13 years of research pioneered at Argonne, the team reports the first high-resolution view of a biohybrid structure, using an electron microscopy method called cryo-EM. With structural information in hand, this advancement opens the door for researchers to develop biohybrid solar fuel systems with improved performance, which would provide a sustainable alternative to traditional energy sources.

Continue reading “Unveiling the structure of a photosynthetic catalyst that turns light into hydrogen fuel” »

A team of engineers is reimagining one of the essential processes in modern manufacturing. Their goal? To transform how a chemical called acrylonitrile (ACN) is made—not by building world-scale manufacturing sites, but by using smaller-scale, modular reactors that can work if they let the catalyst, in a sense, “breathe.”

Their article, titled “Propene Ammoxidation over an Industrial Bismuth Molybdate-Based Catalyst Using Forced Dynamic Operation,” is published in Applied Catalysis A: General.

ACN is everywhere, from carbon fibers in sports equipment to acrylics in car parts and textiles. Traditionally, producing it requires a continuous, energy-intensive process. But now, researchers at the University of Virginia and the University of Houston have shown that by pausing to “inhale” fresh oxygen, a chemical catalyst can produce ACN more efficiently. This discovery could open the door to smaller, versatile production facilities that adapt to fluctuating needs.