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Category: chemistry – Page 8

Brain histamine map connects genes to brain function and mental health

New research from King’s College London and the University of Porto has mapped the histamine system in the brain. Histamine, a molecule more commonly associated with allergies, plays a separate but poorly understood role in brain function. This study addresses this gap, building the first multiscale map of the histamine system that spans from genetics to behavior and related mental health conditions.

The findings provide a new framework for understanding how this often-overlooked chemical system contributes to brain function and could point toward new treatment strategies for histamine-related conditions such as depression, ADHD, and schizophrenia. The study is published in Nature Mental Health.

Histamine is a neurotransmitter, a molecule crucial for neurons to communicate with one another. Neuroscience research has classically focused on understanding other neurotransmitter systems such as dopamine and serotonin.

Chemists discover and isolate a new boron–oxygen molecule

Oxygen is a cornerstone of chemistry, largely because it is so good at building the organic molecules that make up our world. Some oxygen-based compounds called peroxides are famous for being highly reactive—they act like oxygen delivery trucks, transferring atoms to other molecules. This process is essential for everything from creating new medicines to industrial manufacturing.

In a study published in Nature Chemistry, researchers from the labs of MIT professors Christopher C. Cummins and Robert J. Gilliard, Jr. have revealed a brand-new type of peroxide containing boron. This molecule, called a dioxaborirane, represents a major advance in a field where such structures were long-proposed, but considered too unstable to actually isolate.

7 Terrifying Theories That Suggest Aliens Actually Exist

In 1995, when Michel Mayor and Didier Queloz confirmed the first exoplanet orbiting a Sun-like star, the discovery answered one question but ignited a far deeper one: if planets are everywhere, could life be as well. For decades, this remained speculation, until a new generation of instruments transformed astronomy into something far more intimate. Using the Hubble Space Telescope and later the far more powerful James Webb Space Telescope, scientists began analyzing the atmospheres of distant worlds by capturing the faint starlight filtering through them, decoding chemical fingerprints from across hundreds of light-years.

Chronic obstructive pulmonary disease develops over decades — and we are missing the window to prevent it

Although cigarette smoking remains the main driver of COPD, e-cigarettes are also raising concerns. Vaping aerosols can contain nicotine, ultrafine particles and flavouring chemicals that may irritate the lungs and contribute to inflammation. The long-term effects are still unclear because these products are relatively new.

That matters particularly for younger people. In Great Britain, recent survey data suggest that 7% of 11-to 17-year-olds currently vape. While that does not mean they will go on to develop COPD, it does mean more young lungs are being exposed to substances whose long-term effects are not yet fully understood.

COPD is often diagnosed only after major lung damage has already occurred. Because it develops so gradually, people may dismiss early breathlessness, coughing or mucus production as a consequence of getting older, being unfit or smoking. Respiratory organisations warn that symptoms such as cough, phlegm and shortness of breath should not be treated as a normal part of ageing, while studies show that COPD remains widely underdiagnosed, including among people with respiratory symptoms.

Light reshapes metal-organic framework to harvest airborne water

Chemists at the University of Iowa have created a three-dimensional lattice that captures water from the air and stores it. In a new study appearing in the Journal of the American Chemical Society, researchers describe a millimeter-scale structure made of metal atoms connected by two types of organic molecules. When exposed to ultraviolet light, the material undergoes a chemical reaction that changes its shape, creating cavities throughout the lattice. Those cavities attract water molecules from the air and store them—like a multitude of tiny canteens.

The results, which would need to be tested at larger scales, show promise as a method to help provide drinking water to people and areas with limited access. Water stress or scarcity will affect nearly five billion people—half the world’s projected population—by 2050, according to the United Nations.

“We have found and validated a way to capture and to store water that would require only sunlight,” says Leonard MacGillivray, adjunct professor in the Department of Chemistry and former professor and department chair. “You can transport the crystal lattice and eventually release the water on demand. That’s why it’s such an advance.”

Quantum battery charges in a quadrillionth of a second with a laser — larger prototypes could last for years after charging for just a minute

This allows all molecules within the battery to charge at a constant speed, no matter its size. The more molecules involved, the more efficiently energy is absorbed throughout the system, meaning charging times actually decrease in real terms as the battery size increases.

“Similar to conventional batteries, quantum batteries charge, store and discharge energy,”, explained Hutchinson in the statement. “But while everyday batteries rely on chemical reactions, quantum batteries leverage properties of quantum mechanics. The advantage of quantum is that the system absorbs light in a single, giant ‘super absorption’ event and this charges the battery faster.”

CRISPR safeguard changes how engineered microbes can be controlled

Engineered microorganisms are widely used in industrial biotechnology and biopharmaceutical applications, including the production of biofuels, sustainable chemicals, and therapeutic compounds. However, concerns remain regarding the unintended environmental release and uncontrolled proliferation of genetically engineered microbes. For this reason, biocontainment technologies, which are designed to prevent microorganisms from surviving outside controlled environments, have become increasingly important in both academia and industry.

Conventional biocontainment strategies have relied on auxotrophy-based approaches, toxin–antitoxin systems, or DNA cleavage-based technologies such as CRISPR-Cas9. However, these methods often suffer from environmental dependency, genetic instability, and the risk of unintended mutations and cellular stress caused by DNA double-strand breaks.

In particular, DNA cleavage-based systems may compromise genomic stability and allow certain mutant cells to escape survival control. In addition, CRISPR interference (CRISPRi)-based systems are inherently reversible, posing challenges for achieving complete and permanent control of cell viability.

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