Lifeboat Foundation

Cotton is the primary source of natural fiber on Earth, yet only four of 50 known species are suitable for textile production. Computer scientists at DePaul University applied a bioinformatics workflow to reconstruct one of the most complete genomes of a top cotton species, African domesticated Gossypium herbaceum cultivar Wagad. Experts say the results give scientists a more complete picture of how wild cotton was domesticated over time and may help to strengthen and protect the crop for farmers in the U.S., Africa and beyond.

The findings are published in the journal G3 Genes|Genomes|Genetics. Thiru Ramaraj, assistant professor of computer science in DePaul’s Jarvis College of Computing and Digital Media, is lead author on the publication. Leaps in technological advancement in the past decade made it possible for Ramaraj to analyze the genome in his Chicago lab.

“The power of this technology is it allows us to create high-quality genomes that supply a level of detail that simply wasn’t possible before,” says Ramaraj, who specializes in bioinformatics. “This opens up the possibility for more researchers to sequence many crops that are important to the global economy and to feeding the population.”

Maryland-based IonQ is expanding the commercial availability of its next-generation Forte quantum computer — and ramping up its research and production facility in the Seattle area to work on the next, next generation.

Forte is expected to bring the quantum frontier closer to the point that customers can start running real-world applications rather than merely experimenting with quantum capabilities, said Chris Monroe, co-founder and chief scientist at IonQ.

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Analyst Ming-Chi Kuo claims that Apple will “aggressively upgrade” its iPhone hardware to better integrate with the new Apple Vision Pro.

It’s only to be expected that Apple sees its Vision Pro as part of the company’s ecosystem of devices and services, but analyst Ming-Chi Kuo claims to know the specifics of Apple’s hardware plans.

Speaking of both the 2023 and 2024 iPhone releases, Kuo says that “Apple will aggressively upgrade hardware specifications to build a more competitive ecosystem for Vision Pro.”

Quantum computing, just like traditional computing, needs a way to store the information it uses and processes. On the computer you’re using right now, information, whether it be photos of your dog, a reminder about a friend’s birthday, or the words you’re typing into browser’s address bar, must be stored somewhere. Quantum computing, being a new field, is still working out where and how to store quantum information.

In a paper published in the journal Nature Physics, Mohammad Mirhosseini, assistant professor of electrical engineering and applied physics, shows a new method his lab has developed for efficiently translating electrical quantum states into sound and vice versa. This type of translation may allow for storing quantum information prepared by future quantum computers, which are likely to made from electrical circuits.

This method makes use of what are known as phonons, the sound equivalent of a light particle called a photon. (Remember that in quantum mechanics, all waves are particles and vice versa). The experiment investigates phonons for storing quantum information because it’s relatively easy to build small devices that can store these mechanical waves.

Low-cost, flexible displays that use very little energy could be a step closer, thanks to an innovation from the University of Surrey that solves a problem that has plagued source-gated transistors (SGT). The study has been published by IEEE Transactions on Electron Devices.

Dr. Radu Sporea, project lead from the University of Surrey, said, We used a rapidly emerging semiconductor material called IGZO or indium-gallium-zinc oxide to create the next generation of source-gated transistors. Through nanoscale contact engineering, we obtained transistors that are much more stable with temperature than previous attempts. Device simulations allowed us to understand this effect.

This new design adds temperature stability to SGTs and retains usual benefits like using low power, producing high signal amplification, and being more reliable under different conditions. While source-gated transistors are not mainstream because of a handful of performance limitations, we are steadily chipping away at their shortcomings.

Immunotherapy is a fast-growing field designed to stimulate the immune system and target different diseases, including cancer. Some immunotherapies include immune cell activation therapies such as checkpoint inhibitors that block the interaction of cell markers which in turn allows the cell to kill the bound tumor cell. One example of a checkpoint inhibitor is anti-programmed cell death-1 (Anti-PD-1). Programmed cell death-1 (PD-1) is expressed on immune cells, specifically T cells. On responsibility of T cells include killing infected cells, such as cancer. The PD-1 marker is bound to PD-L1 on the infected cell and blocks the T cell’s ability to kill the tumor. Checkpoint inhibitors are effective in some subsets of cancer patients, but in more aggressive cancers such as liver cancer, immunotherapy is limited. Interestingly, a recent study in Nature Medicine by Dr. Miriam Merad and colleagues from the Ichan School of Medicine at Mount Sinai recently reported a new strategy to improve immunotherapy in liver cancer.

Merad and colleagues have uncovered a “trio of immune cells” within the tumor that helps improve immunotherapy. Researchers discovered this cohort of cells specifically in hepatocellular carcinoma (HCC), an aggressive and deadly liver cancer. It was demonstrated that specific populations in the tumor would be needed to activate T cells with immunotherapy, specifically anti-PD-1. Increased activation of T cells in HCC is critical because it demonstrates that an aggressive tumor has become sensitized to the immune system.

Researchers studied this phenomenon in patients to determine why some immune cells present in the tumor allow improved immunotherapy response, while others do not. The research team analyzed patient samples before and after checkpoint inhibitor treatment. Analysis was performed through computational methods, which allowed Merad and others to determine the immune cells necessary that help patients improve with immunotherapy. Through this computational cell analysis researchers are able to improve patient outcomes by determining if the “trio of cells” is present in the tumor.

An international team of researchers, led by University of Toronto Engineering Professor Yu Zou, is using electric fields to control the motion of material defects. This work has important implications for improving the properties and manufacturing processes of typically brittle ionic and covalent crystals, including semiconductors—a crystalline material that is a central component of electronic chips used for computers and other modern devices.

In a new study published in Nature Materials, researchers from University of Toronto Engineering, Dalhousie University, Iowa State University and Peking University, present real-time observations of dislocation motion in a single-crystalline zinc sulfide that was controlled using an external electric field.

Continue reading “Using electric fields to control the movement of defects in crystals” »

The company wants to make large-scale quantum computers a reality within just 10 years.

Researchers at Microsoft say they have created elusive quasiparticles called Majorana zero modes – but scientists outside the company are sceptical.

By Karmela Padavic-Callaghan