Lifeboat Foundation

It’s going to get even worse, says the CEO in the earnings call.

Mark Zuckerberg’s dream of building the future of the internet is costing Meta billions of dollars every quarter. In the quarterly earnings call on Wednesday, Reality Labs, Meta’s division tasked with building the metaverse, reported a loss of $3.67 billion in the period between July through September, up from $2.8 billion in the previous quarter, Engadget.

IStock/COM & O

Continue reading “Mark Zuckerberg’s metaverse dream is costing billions — and Meta plans to spend more next year” »

Protecting People, Society & Environment — Lydie Evrard, Deputy Director General; Head, Department of Nuclear Safety & Security, International Atomic Energy Agency (IAEA)

Lydie Evrard (https://www.iaea.org/about/organizational-structure/departme…d-security) is Deputy Director General and Head of the Department of Nuclear Safety and Security at the International Atomic Energy Agency (IAEA).

Continue reading “Lydie Evrard — Deputy Director General, IAEA — Head of the Department of Nuclear Safety and Security” »

Tesla is rumored to be looking to invest in Nuevo Leon, a Mexican state bordering Texas, as CEO Elon Musk meets with the governor.

Earlier this year, people crossing the border between Texas and Nuevo Leon were surprised to see not just the usual marked lanes for cars and trucks but also one marked “Tesla” – pictured above.

We ended up finding out that Tesla had struck a deal with the state of Nuevo Leon to have its own lane at the border crossing in order to reduce wait times for cargo going through the border. Or at least that was the explanation of Ivan Rivas, the economy minister of Nuevo Leon.

Researchers created an artificial intelligence process that determines when and where wildfires will occur.

Wildfires have caused extreme fire damages across the globe, along with many deaths. It is significant to know when wildfires are spreading, and where, to prevent loss of life. Realizing this important information in advance is key. Forecasting wildfire danger can be a difficult task because of the complexity involving climate system, interactions with vegetation and socio-economic components.

Currently, available information for widespread fires only provides limited data and information.

Continue reading “A newly developed AI-based method can accurately predict wildfires” »

Just a quick vid. He mentions the hope of replacing current gene therapy with a pill or three which I heard Cynthia Kenyon say many years ago.

Dr David Sinclair talks about longevity genes, genes therapies and his works on resetting the eyes in this short clip.

Continue reading “That Our Body Has A MEMORY OF YOUTH Has Been Proved | Dr David Sinclair Interview Clips” »

The Taiwanese firm TSMC is the world’s largest chipmaker. But if tensions boil over with China, it could have trillions of dollars of economic costs.

Factories have added 467,000 jobs in the last 12 months, as production jumped to its highest level since 2008. But manufacturing remains a much smaller slice of the U.S. economy than it used to be.

The tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. The Taraxacum genus from the Asteraceae family is found in the temperate zone of the Northern hemisphere. It is available in several areas around the world. In many countries, it is used as food and in some countries as therapeutics for the control and treatment of T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, and sesquiterpene lactones. Studies have outlined the useful pharmacological profile of dandelion for the treatment of an array of diseases, although little attention has been paid to the effects of its bioactive components on T2D to date. This review recapitulates previous work on dandelion and its potential for the treatment and prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, and their potential mechanisms of action in T2D. Although initial research appears promising, data on the cellular impact of dandelion are limited, necessitating further work on clonal β-cell lines (INS-1E), α-cell lines, and human skeletal cell lines for better identification of the active components that could be of use in the control and treatment of T2D. In fact, extensive in-vitro, in-vivo, and clinical research is required to investigate further the pharmacological, physiological, and biochemical mechanisms underlying the effects of dandelion-derived compounds on T2D.

Keywords: type 2 diabetes, dandelion, chlorogenic acid, chicory acid, taraxasterol, sesquiterpene.

Abbreviations: ADP — adenosine diphosphate; AFLD — alcoholic fatty liver disease; AMPK — adenosine monophosphate-activated protein kinase; ATP — adenosine triphosphate; cAMP — cyclic adenosine monophosphate; CGA — chlorogenic acid; CoA — coenzyme A; CRA — chicory acid; DAG — diacylglycerol; DBD — DNA-binding domain; DNA — deoxyribonucleic acid; DPPH — 2,2-diphenyl-1-picrylhydrazyl; Dw — dry weight; FOS — fructose oligosaccharide; G6P — glucose-6-phosphate; GDP — guanosine 5’-diphosphate; GLP-1 — glucagon-like peptide 1; GLUT2 — glucose transporter 2; GLUT4 — muscle glucose transporter protein 4; GPCR — G protein-coupled receptor; GTP — guanosine triphosphate; HNB — 2-hydroxy-5-nitrobenzenaledehyde; HPLC — high-pressure liquid chromatography; IC₅₀ — half maximal inhibitory concentration; IDF — International Diabetes Federation; IDX-1 — islet duodenum homeobox 1; IL-1α — interleukin 1 alpha; INS-1E — rat insulinoma clonal beta-cell line; IR — insulin receptor; IRS-1 — insulin receptor substrate 1; Km — Michaelis constant; IP3 — inositol triphosphate; IRS-1 — insulin receptor substrate 1; LBD — ligand-binding domain; LC-DAD — liquid chromatography with (photo) diode array detection; LPS — lipopolysaccharide; MAPK — mitogen-activated protein kinase; NADH — nicotinamide adenine dinucleotide; NAFLD — non-alcoholic fatty liver disease; NF-κb — nuclear factor kappa B; NO — nitric oxide; PI3K — phosphatidylinositol 3 kinase; PKA — protein kinase A; PKC — protein kinase C; PPAR-γ — peroxisome proliferator-activated receptor gamma; ROS — reactive oxygen species; RxR — retinoid X receptor; SEL — sesquiterpene lactones; SUR1 — sulphonylurea receptor 1; T2D — type 2 diabetes; TAG — triacylglycerol; TNF-α — tumor necrosis factor; TO — Taraxacum officinale; TS — taraxasterol; UPLC-MS/MS — ultra-performance liquid chromatography — tandem mass spectrometry; UV/VIS — ultraviolet visible; WHO — World Health Organization.

This GB Live News is in partnership with VB Lab funded by Xsolla.

Video games have always been resilient, even in an increasingly volatile geopolitical climate. Long-time game players are fiercely loyal, and enthusiastic new gamers keep pouring into the market, says Chris Hewish, president of Xsolla. In the first half of 2022 alone, more than 651 deals were announced or closed, for a value of $107 billion. But in a fiercely competitive market, clouded by less economic certainy, studios and indie developers are exploring an increasing number of ways to reach the audiences.

“Game companies do need to look at how their business models can function in a macroeconomic climate, heading into a recession,” he added. “Capital is going to become tighter. If you have a business model based upon growth over profitability, it’s going to be harder to find fuel for that growth. Readjusting to focus on profitability is probably one of the biggest things game companies can do right now, if they haven’t already, to weather the storm in a macro sense. But the opportunity with players and the number of people playing and spending, that’s still looking good.”