Lifeboat Foundation

Rare diseases aren’t so rare. Collectively, up to 30 million Americans, many of them children, are born with one of the approximately 7,000 known rare diseases. Most of these millions of people also share a common genetic feature: their diseases are caused by an alteration in a single gene.

Many of these alterations could theoretically be targeted with therapies designed to correct or replace the faulty gene. But there have been significant obstacles in realizing this dream. The science of gene therapy has been making real progress, but pursuing promising approaches all the way to clinical trials and gaining approval from the U.S. Food and Drug Administration (FDA) is still very difficult. Another challenge is economic: for the rarest of these conditions (which is most of them), the market is so small that most companies have no financial incentive to pursue them.

To overcome these obstacles and provide hope for those with rare diseases, we need a new way of doing things. One way to do things differently—and more efficiently—is the recently launched Bespoke Gene Therapy Consortium (BGTC). It is a bold partnership of NIH, the FDA, 10 pharmaceutical companies, and several non-profit organizations [1]. Its aim: optimize the gene therapy development process and help fill the significant unmet medical needs of people with rare diseases.

A shift to digital life?

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Speaker:
James L. Burk.
Commander, MDRS Crew 261.
Executive Officer, MDRS Crew 197.
Director of IT & MarsVR, The Mars Society.
Former Senior Technical Project Manager, Microsoft.

Track Code: AM-2

Continue reading “MDRS Crew 261 Mars Analog Experiments — James L. Burk — 2021 Mars Society Virtual Convention” »

China’s rich aren’t sleeping well these days. As President Xi Jinping’s campaign to redistribute income gains momentum, the wealthy are on the defensive, deleting social media profiles and moving money around with an eye toward the next crackdown.

The new emphasis on protection is a shift for the upper classes, who have for years benefited from stellar economic growth and a relaxed official attitude to personal fortune. The country created a new billionaire every week in 2,021 bringing the total to more than 750 — more than India, Russia and Germany combined and just behind an estimated 830 in the U.S., according to the Bloomberg Billionaires Index.

China’s economy — the 2nd-largest in the world — is teetering on the brink of disaster.

Since this spring, Beijing has canceled initial public offerings, fined tech companies billions for antitrust violations, forcibly shut down China’s entire for-profit education industry, and sent CEOs running for the exits to avoid the government’s ire. Even more dire, the Chinese megadeveloper Evergrande recently started missing payments on its more than $300 billion in debt, shaking global markets. The convulsions have woken the world up to a startling new possibility — that Beijing may be willing to allow some of its private corporate behemoths to collapse in a bid to reshape the economic model that made China a superpower.

Continue reading “If China’s economy keeps stumbling, it won’t just take down Beijing — the whole world will collapse with it” »

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Progress has an accelerating rate of change due to the compounding effect of these technologies, in which they will enable countless more from 3D printing, autonomous vehicles, blockchain, batteries, remote surgeries, virtual and augmented reality, robotics – the list can go on and on.

Continue reading “Our Autonomous Future (How Automation Will Change The World)” »

The COVID-19 pandemic, caused by SARS-CoV-2, continues to rage in many countries, straining health systems and economies. Vaccines protect against severe disease and death and are considered central to ending the pandemic. COVID-19 vaccines (and SARS-CoV-2 infection) elicit antibodies that are directed against the viral spike (S) protein and neutralize the virus. However, the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1]. Furthermore, emerging viral variants with enhanced transmissibility, likely due to altered virus-host cell interactions, might rapidly spread globally. Therefore, it is important to investigate whether emerging SARS-CoV-2 variants exhibit altered host cell interactions and resistance against antibody-mediated neutralization.

Cellular & Molecular Immunology (2021) Cite this article.

Track code: TD-3

Abstract:
Solar Sails are at the same stage of engineering development as electric motors were in the 1830’s. Each attribute of solar flux has been examined in isolation, such as photon, proton, plasma, and electrodynamic systems. This talk recommends designing a simple baseline system that converges multiple propulsion methods into optimized systems, as is currently done with electric motors. Many convergences can come from this solution space. Once a baseline design is created, AI genetic algorithms can “flight test” and refine the designs in simulation to adjust proportions and geometry. Once a base design is refined, a second AI evolution pass would design fleet systems that flock like birds to optimize performance. These could fly as a protective shield around Mars crewed fleets, provide space based solar power, deploy rapid reaction probes for interstellar comets, and be used in NEO asteroid mining. In the long term, fleets of solar energy management vehicles can provide orbital Carrigan event protection and Martian solar wind protection for terraforming. This talk is also a case study in how technology revolutions happen, and how to accelerate the creation and democratization of technical solutions.

Continue reading “FlexSail: Solar Sails and Tech Revolutions — Kent Nebergall — 2021 Mars Society Virtual Convention” »

Alfredo Munoz — Digital Twins of Martian Cities as a new frontier for Space Analogs.

From the 24th Annual International Mars Society Convention, held as a Virtual Convention worldwide on the Internet from October 14–17, 2021. The four-day International Mars Society Convention, held every year since 1,998 brings together leading scientists, engineers, aerospace industry representatives, government policymakers and journalists to talk about the latest scientific discoveries, technological advances and political-economic developments that could help pave the way for a human mission to the planet Mars.

Continue reading “Digital Twins of Martian Cities — Alfredo Munoz — 2021 Mars Society Virtual Convention” »