Follow our step-by-step video guide for growing cerebral organoids, or brain organoids, from human pluripotent stem cells (hPSCs). We’ll walk you through embryoid body formation, induction, expansion, and organoid maturation.
The journal Nature published a groundbreaking new study by world-renowned Stanford neuroscientist Sergiu Pasca involving the transfer of human brain organoids into the brains of rats. Insoo Hyun, Director of the Center for Life Sciences and Public Learning at the Museum of Science, speaks candidly with Dr. Pasca about his research. Why did he do it? How might this uncover the mysteries of psychiatric disorders? And the Big Question we are all wondering about – can these rats ever develop “human-like” consciousness? Together they demystify the science.
00:33 Dr. Sergiu Pasca’s Romanian roots. 00:55 Why is Dr. Pasca’s work important for Psychiatry? 04:14 Dr. Pasca’s work with human brain organoids. 06:14 Challenges with using animal brains when trying to unlock mysteries of human psychiatric disorders. 07:13 Reason for Dr. Pasca’s latest research transplanting human brain organoids into rat brains. 08:47 How the human brain organoid transplantation into a rat brain is accomplished. 10:19 What Dr. Pasca learned from his experiment and its importance. 12:02 Brain cells’ amazing ability to take over and organize themselves in appropriate environments. 13:03 Will animals with human brain organoids in their brain develop human-like consciousness? 17:30 Will manipulating human neurons in a rat change the behavior of the rat? 19:43 Application of rat experiment findings for human patients. 22:07 The ethics and regulation of using animals in scientific research. 25:25 Why context matters in research of transplanting human brain organoids into rat brains and the challenge of people backfilling science they might not understand with mythology and science fiction. 32:28 Dr. Pasca’s inspiration to work so hard to unlock the mysteries of psychiatric disorders.
“The Big Question” is a production of the Museum of Science, Boston.
Among the world’s largest science centers, the Museum of Science engages millions of people each year to the wonders of science and technology through interactive exhibitions, digital programs, giant screen productions, and preK – 8 EiE® STEM curricula through the William and Charlotte Bloomberg Science Education Center. Established in 1,830, the Museum is home to such iconic experiences as the Theater of Electricity, the Charles Hayden Planetarium, and the Mugar Omni Theater. Around the world, the Museum is known for digital experiences such as Mission: Mars launching in 2022 on Roblox, and traveling exhibitions such as the Science Behind Pixar.
Getty Images Two US high schoolers believe they have cracked a mathematical mystery left unproven for centuries. Calcea Johnson and Ne’Kiya Jackson looked at the Pythagorean theorem, foundational to trigonometry. The American Mathematical Society said the teenagers should submit their findings to a journal. Two high school seniors from New Orleans think they have managed to prove a 2,000-year-old theorem that has stumped mathematicians for centuries.
Pensions behave as government mandated ponzi schemes. New contributors are needed to pay for past contributors. But what if there are less and less new contributors and contributions? And what if past generations live longer and longer lives?
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France is facing massive protests in response to its recently announced pension reform. While France is the only country facing massive protests for now, almost all developed countries will likely be forced to conduct similar pension reforms in the future as they face rapidly aging populations.
0:00 — 1:50 Intro. 1:51 — 5:03 French pension system. 5:04 — 7:15 The Ponzi scheme. 7:16 — 9:42 Pension crisis. 9:43 — 11:20 Demographic time bomb. 11:21 A warning to us all.
ChatGPT’s impact extends beyond the education sector and is causing significant changes in other areas. The AI language model is recognized for its ability to perform various tasks, including paper writing, translation, coding, and more, all through question-and-answer-based interactions.
The AI system relies on deep learning, which requires extensive training to minimize errors, resulting in frequent data transfers between memory and processors. However, traditional digital computer systems’ von Neumann architecture separates the storage and computation of information, resulting in increased power consumption and significant delays in AI computations. Researchers have developed semiconductor technologies suitable for AI applications to address this challenge.
A research team at POSTECH, led by Professor Yoonyoung Chung (Department of Electrical Engineering, Department of Semiconductor Engineering), Professor Seyoung Kim (Department of Materials Science and Engineering, Department of Semiconductor Engineering), and Ph.D. candidate Seongmin Park (Department of Electrical Engineering), has developed a high-performance AI semiconductor device using indium gallium zinc oxide (IGZO), an oxide semiconductor widely used in OLED displays.
Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.
The Rise Of Genetic Engineering (2022) Writers: Kyle McCabe, Christopher Webb Young. Stars: Rodolphe Barrangou, George Church, Mary Beth Dallas. Genre: Documentary. Country: United States. Language: English. Release Date: August 24, 2022 (United States)
Synopsis: Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.
Methods like this allow scientists to alter and ‘re-program’ the genetics of living organisms.
This episode shows scientists at large using gene-editing technologies to revolutionize the food supply chain, bolstering food crops to prevent famines, and even speed up reforestation efforts that will reverse global warming. Genetic Engineering in farm animals is helping scientists to ‘select’ desirable traits, like physical features and gender. Incredibly, one scientist is using gene-editing technologies to resurrect the DNA of extinct species, like the Wooly Mammoth!
Despite some public concern, gene-editing is definitely a cause for hope in the fight against genetic disorders in humans. It’s already reversing a type of congenital blindness in children. And with the hyper-precision afforded by PRIME editing being prepared for clinical trials, a much more hopeful world will be revealed for families in the future.
A new, giant species of trapdoor spider has been discovered in Queensland, Australia, which researchers are describing as “rare” and “secretive.”
The species, Euoplos dignitas, was identified after four years of intensive fieldwork by researchers at Queensland Museum, following the discovery of an undescribed species in the museum’s collection.
“This species was first known from older specimens stored in the Queensland Museum collection, mostly collected in the early and mid-20th century,” Michael Rix, principal curator of arachnology at Queensland Museum, who led the study, told Newsweek.
Atmospheric physicists and NASA officials on Tuesday called this a major step forward in pollution monitoring. TEMPO will let scientists see emissions as they occur throughout the day, hour by hour, instead of a single sampling. The project involves members from the National Oceanic and Atmospheric Administration (NOAA) and the Environmental Protection Agency (EPA).
😗 I am actually pretty happy about this because full automation will simply life rather than needing as much education the AI can do most of the work much like the star trek computer. Full automation will allow for more freedom even from common tasks allowing the AI to most of the thinking and tasks.
A senior developer tested GPT4 for programming. GPT4 gave the Terraform script code for a single instance of the Fargate API. GPT4 knows that the code will not scale to 10,000 requests per second. It then describes how to create an auto-scaling group and make the modifications to scale the code with AWS and configure the application load balancer.
NOTE: his prompt was way more detailed than an ordinary person would produce. An ordinary person would not be able to verify the results either. You can make the case for 10x or 100x programmer productivity. A senior developer can become a programming lead or manager guiding the AI prompt requests from the equivalent of multiple programming teams.
The advantage will not be to let people who do not know a topic to play with powerful tools. The advantage is to increase the productivity and capacity of competent people to do more in areas that they understand. The AI tools will uplevel the productivity in areas where you know what can and should be done. You do not want someone who does not know how to drive behind the wheel of a Formula One race car.
