Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: engineering – Page 189

Engineering an immunotherapy to outwit cancer — and launch a biotech

Tweaking an immune protein called interleukin-18 can overcome tumors that lure it into binding with a decoy receptor protein and render it harmless to cancer cells, new research in mice shows. In conjunction with the paper, published Wednesday in Nature, a company founded by senior author Aaron Ring announced $25 million in initial financing to create and commercialize a drug based on the discovery.

The approach adds another weapon to an immunotherapy arsenal that activates immune responses hijacked by cancer. Checkpoint inhibitors, for example, take the brakes off immune cells that should battle invaders. IL-18 is a cytokine that normally activates T cells and natural killer cells, two immune forces that fight infection, but it’s disarmed by the decoy wielded by tumors.

Experiment confirms 50-year-old theory describing how an alien civilization could exploit a black hole

Aliens & Black Holes

Penrose predicted that the object would acquire a negative energy in this unusual area of space. By dropping the object and splitting it in two so that one half falls into the black hole while the other is recovered, the recoil action would measure a loss of negative energy—effectively, the recovered half would gain energy extracted from the black hole’s rotation. The scale of the engineering challenge the process would require is so great, however, that Penrose suggested only a very advanced, perhaps alien, civilisation would be equal to the task.

A 50-year-old theory that began as speculation about how an alien civilization could use a black hole to generate energy has been experimentally verified for the first time in a Glasgow research lab.

MIT Automated Tabletop Fast Protein Synthesis Machine May Accelerate Drug Development

Automated tabletop machine could accelerate the development of novel drugs to treat cancer and other diseases.

Many proteins are useful as drugs for disorders such as diabetes, cancer, and arthritis. Synthesizing artificial versions of these proteins is a time-consuming process that requires genetically engineering microbes or other cells to produce the desired protein.

MIT chemists have devised a protocol to dramatically reduce the amount of time required to generate synthetic proteins. Their tabletop automated flow synthesis machine can string together hundreds of amino acids, the building blocks of proteins, within hours. The researchers believe their new technology could speed up the manufacturing of on-demand therapies and the development of new drugs, and allow scientists to design artificial proteins by incorporating amino acids that don’t exist in cells.

‘Janus’ nanorods convert light to heat that can destroy pollutants in water

With a new nanoparticle that converts light to heat, a team of researchers has found a promising technology for clearing water of pollutants.

Trace amounts of contaminants such as pesticides, pharmaceuticals and perfluorooctanoic acid in drinking water sources have posed significant health risks to humans in recent years. These micropollutants have eluded conventional treatment processes, but certain chemical processes that typically involve ozone, hydrogen peroxide or UV light have proven effective. These processes, however, can be expensive and energy-intensive.

A new nanoparticle created by Yale University engineers as part of an effort for the Rice-based Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment (NEWT) could lead to technologies that get around those limitations. The particle is described in a study published this week in the Proceedings of the National Academy of Sciences.

Synthetic Plasma Liquid Based Electronic Circuits Realization-A Novel Concept

Circa 2016

Biomedical research is contributing significant role in the field of biomedical engineering and applied science. It brings research and innovations to a different level. This study investigated artificial human blood –synthetic plasma liquid as conductive medium. Keeping in mind the conductivity of synthetic plasma, astable multivibrator as well as differential amplifier circuit were demonstrated. The circuits were given normal input voltages at regular temperature and ideal conditions. The result shows desired response which supports the novel concept. For both the circuits, phase shift of 180° achieved by analysing biological electronic circuits.

Keywords: Synthetic plasma, biomedical science, human body.

Tesla Model 3 gets a solar roof thanks to Lightyear

A Tesla Model 3 has been modified with a solar roof as part of Lightyear’s solar car development program.

We have been reporting on Lightyear for a few years now.

The startup first caught our attention because it spun out of Solar Team Eindhoven, a group of engineering students from the Technical University of Eindhoven (Netherlands) who have been competing in the World Solar Challenge with their Stella and Stella Lux, energy positive solar cars — meaning that they can produce more energy than they consume.

Discovering how the brain works through computation

Accelerating progress in neuroscience is helping us understand the big picture—how animals behave and which brain areas are involved in bringing about these behaviors—and also the small picture—how molecules, neurons, and synapses interact. But there is a huge gap of knowledge between these two scales, from the whole brain down to the neuron.

A team led by Christos Papadimitriou, the Donovan Family Professor of Computer Science at Columbia Engineering, proposes a new computational system to expand the understanding of the brain at an intermediate level, between and cognitive phenomena such as language. The group, which includes computer scientists from Georgia Institute of Technology and a neuroscientist from the Graz University of Technology, has developed a brain architecture that is based on neuronal assemblies, and they demonstrate its use in the syntactic processing in the production of language; their model, published online June 9 in PNAS, is consistent with recent experimental results.

“For me, understanding the brain has always been a computational problem,” says Papadimitriou, who became fascinated by the brain five years ago. “Because if it isn’t, I don’t know where to start.”

Sound waves transport droplets for rewritable lab-on-a-chip devices

Engineers at Duke University have demonstrated a versatile microfluidic lab-on-a-chip that uses sound waves to create tunnels in oil to touchlessly manipulate and transport droplets. The technology could form the basis of a small-scale, programmable, rewritable biomedical chip that is completely reusable to enable on-site diagnostics or laboratory research.

The results appear online on June 10 in the journal Science Advances.

“Our new system achieves rewritable routing, sorting and gating of droplets with minimal external control, which are essential functions for the digital logic control of droplets,” said Tony Jun Huang, the William Bevan Distinguished Professor of Mechanical Engineering and Materials Science at Duke. “And we achieve it with less energy and a simpler setup that can control more droplets simultaneously than previous systems.”

Extremely brilliant giga-electron-volt gamma rays from a two-stage laser-plasma accelerator

Laser-wakefield accelerators have led to the development of compact, ultrashort X-ray or gamma-ray sources to deliver peak brilliance, similar to conventional synchrotron sources. However, such sources are withheld by low efficiencies and limited to 107–8 photons per shot in the kiloelectron volt (KeV) to megaelectron volt (MeV) range. In a new report now published on Science Advances, Xing-Long Zhu and a research team in physics and astronomy in China and the U.K., presented a new approach to efficiently produce collimated, ultrabright gamma (γ)-ray beams. The resulting photon energies were tunable for up to gigaelectron volts by focussing a multi-petawatt laser pulse into a 2-stage wakefield accelerator. The high-intensity laser allowed them to efficiently generate a multi-gigaelectron volt electron beam with a high density and charge during the first stage of the experiment. The laser and electron beams entered a high-density plasma region in the second stage thereafter. Using numerical simulations, they demonstrated the production of more than 1012 gamma ray photons per shot with energy conversion efficiency above 10 percent for photons above 1 megaelectron volt (MeV) and achieved a peak brilliance above 1026 photons S-1 mm-2 mrad-2 per 0.1 percent bandwidth at 1 MeV. This research outcome will offer new avenues in both fundamental and applied physics and engineering.

Bright sources of high-energy gamma rays are versatile for broad areas of applications, including fundamental research in astrophysics, particle and nuclear physics, as well as high-resolution imaging. Researchers can improve such applications with compact gamma ray sources with low divergence, short pulse duration, high energy, and high peak brilliance. While widely used synchrotrons and X-ray free electron lasers (XFELS) can deliver X-ray pulses with peak brilliance, they are limited to low photon energies. The size and cost of such research structures can also limit their regular applications. Researchers have therefore rapidly developed compact laser-wakefield accelerators (LWFAs) in the past two decades to offer a radically different approach to drive the acceleration and radiation of high-energy particles on a much smaller scale. Continuous advancements in the field of ultrahigh-power laser technology will enable brilliant high-energy gamma sources.

Spherical Solar Cells Soak Up Scattered Sunlight

Flat solar panels still face big limitations when it comes to making the most of the available sunlight each day. A new spherical solar cell design aims to boost solar power harvesting potential from nearly every angle without requiring expensive moving parts to keep tracking the sun’s apparent movement across the sky.

The spherical solar cell prototype designed by Saudi researchers is a tiny blue sphere that a person can easily hold in one hand like a ping pong ball. Indoor experiments with a solar simulator lamp have already shown that it can achieve between 15 percent and 100 percent more power output compared with a flat solar cell with the same total surface area, depending on the background materials reflecting sunlight into the solar cells. The research group hopes its nature-inspired design can fare similarly well in future field tests in many different locations around the world.

“The placement and shape of the housefly’s eyes increase their angular field of view so they can see roughly 270 degrees around them in the horizontal field,” says Nazek El-Atab, a postdoctoral researcher in microsystems engineering at the King Abdullah University of Science and Technology (KAUST). “Similarly, the spherical architecture increases the ‘angular field of view’ of the solar cell, which means it can harvest sunlight from more directions.”

/* */