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Category: engineering – Page 21

Microfluidic component library component library enables rapid, low-cost device prototyping

Researchers have developed a freely available droplet microfluidic component library, which promises to transform the way microfluidic devices are created. This innovation, based on low-cost rapid prototyping and electrode integration, makes it possible to fabricate microfluidic devices for under $12 each, with a full design-build-test cycle completed within a single day. The components are biocompatible, high-throughput, and capable of performing multistep workflows, such as droplet generation, sensing, sorting, and anchoring, all critical for automating microfluidic design and testing.

Microfluidics, particularly droplet-based systems, has become a promising technology for diverse fields, including protein engineering, single-cell sequencing, and nanoparticle synthesis. However, the traditional methods of fabricating —typically using PDMS (polydimethylsiloxane)—are time-consuming and costly, often requiring cleanroom facilities or external vendors.

While alternatives like laser cutting and 3D printing have been explored, these methods often suffer from limitations in resolution, material compatibility, and scalability. As a result, there has been an urgent need for a more efficient, cost-effective, and accessible fabrication method to help propel innovation in microfluidic technology.

Light-powered breakthrough enables precision tuning of quantum dots

Researchers at North Carolina State University have demonstrated a new technique that uses light to tune the optical properties of quantum dots—making the process faster, more energy-efficient and environmentally sustainable—without compromising material quality.

The findings are published in the journal Advanced Materials.

“The discovery of quantum dots earned the Nobel Prize in chemistry in 2023 because they are used in so many applications,” says Milad Abolhasani, corresponding author of a paper on the work and ALCOA Professor of Chemical and Biomolecular Engineering at NC State. “We use them in LEDs, , displays, quantum technologies and so on. To tune their , you need to tune the bandgap of quantum dots—the minimum energy required to excite an electron from a bound state to a free-moving state—since this directly determines the color of light they emit.

3D nanoprinting technique can transform ceramics for high-performance systems, from disease detection to space travel

The same material from which you drink your morning coffee could transform the way scientists detect disease, purify water, and insulate space shuttles thanks to an entirely new approach to ceramic manufacturing.

Published in Advanced Science, 3D-AJP is an aerosol jet 3D nanoprinting technique that allows for the fabrication of highly complex ceramic structures that—at just 10 micrometers (a fraction of the width of human hair)—are barely visible to the naked eye. These 3D structures are made up of microscale features including pillars, spirals, and lattices that allow for controlled porosity, ultimately enabling advances in ceramic applications.

“It would be impossible to machine ceramic structures as small and as precise as these using traditional manufacturing methods,” explained Rahul Panat, professor of mechanical engineering at Carnegie Mellon University and the lead author of the study. “They would shatter.”

Researchers spin ‘wheel of fortune’ to find a fundamental proof of quantum mechanics

Researchers from the National University of Singapore (NUS) and University of New South Wales (UNSW) Sydney have proven that a spinning atomic nucleus really is fundamentally a quantum resource. The teams were led respectively by Professor Valerio Scarani, from NUS Department of Physics, and Scientia Professor Andrea Morello from UNSW Engineering. The paper was published in the journal Newton on 14 February 2025.

It has long been inferred that tiny particles such as electrons or protons are indeed quantum due to the way they get deflected in a magnetic field. However, when left to spin freely, they appear to behave in exactly the same way as a classical spinning item, such as a Wheel of Fortune turning on its axis. For more than half a century, experts in spin resonance have taken this fact as a universal truth.

For the same reason, a technician or a doctor operating a (MRI) machine at the hospital never needed to understand quantum mechanics—the spinning of the protons inside the patient’s body produces the same kind of magnetic field that would be created by attaching a fridge magnet to a spinning wheel.

Copper-Based Electrocatalysts: Using Corrosion for Efficient Biomass Upgrading

Researchers at NIMTE have turned metal corrosion into a tool for efficient biomass upgrading, achieving high HMF-to-BHMF conversion rates with a CoCuMW/CF electrode. Their findings offer a low-cost, sustainable solution for bio-based chemical production.

A research team led by Prof. Jian Zhang from the Ningbo Institute of Materials Technology and Engineering (NIMTE) of the Chinese Academy of Sciences (CAS) has harnessed metal corrosion to develop high-performance electrodes, facilitating the efficient and cost-effective upgrading of bio-based 5-hydroxymethylfurfural (HMF). Their findings were published in Chem Catalysis.

While corrosion is typically associated with material degradation and economic loss, researchers are now investigating its potential for advantageous applications, particularly in biomass upgrading.

Learning from catastrophe

Engineers are renowned clock-problem solvers. They’re also notorious for treating every problem like a clock. Increasing specialization and cultural expectations play a role in this tendency. But so do engineers themselves, who are typically the ones who get to frame the problems they’re trying to solve in the first place.

In his latest book, Wicked Problems, Guru Madhavan argues that the growing number of cloudy problems in our world demands a broader, more civic-minded approach to engineering. “Wickedness” is Madhavan’s way of characterizing what he calls “the cloudiest of problems.” It’s a nod to a now-famous coinage by Horst Rittel and Melvin Webber, professors at the University of California, Berkeley, who used the term “wicked” to describe complex social problems that resisted the rote scientific and engineering-based (i.e., clock-like) approaches that were invading their fields of design and urban planning back in the 1970s.

Madhavan, who’s the senior director of programs at the National Academy of Engineering, is no stranger to wicked problems himself. He’s tackled such daunting examples as trying to make prescription drugs more affordable in the US and prioritizing development of new vaccines. But the book isn’t about his own work. Instead, Wicked Problems weaves together the story of a largely forgotten aviation engineer and inventor, Edwin A. Link, with case studies of man-made and natural disasters that Madhavan uses to explain how wicked problems take shape in society and how they might be tamed.

‘Gut-on-chip’ can predict immunotherapy outcomes for melanoma patients

A team of researchers has developed a “gut-on-chip” (a miniature model of the human intestine on a chip-sized device) capable of reproducing the main features of intestinal inflammation and of predicting the response of melanoma patients to immunotherapy treatment. The results have just been published in Nature Biomedical Engineering.

The interaction between microbiota and has long been known. It is the result of both systemic effects, i.e., the elicited in the entire body by immunotherapy, and local processes, especially in the gut, where most of the bacteria that populate our body live. However, the latter can only be studied in animal models, with all their limitations.

Indeed, there is no clinical reason to subject a patient receiving immunotherapy for melanoma to colonoscopy and colon biopsy. Yet intestinal inflammation is one of the main side effects of this treatment, often forcing the therapy to be discontinued.

Scientists Think They Could Revolutionize Computing by Leveraging Quantum Teleportation

To test this new system, the team executed what is known as Grover’s search algorithm—first described by Indian-American computer scientist Lov Grover in 1996. This search looks for a particular item in a large, unstructured dataset using superposition and entanglement in parallel. The search algorithm also exhibits a quadratic speedup, meaning a quantum computer can solve a problem with the square root of the input rather than just a linear increase. The authors report that the system achieved a 71 percent success rate.

While operating a successful distributed system is a big step forward for quantum computing, the team reiterates that the engineering challenges remain daunting. However, networking together quantum processors into a distributed network using quantum teleportation provides a small glimmer of light at the end of a long, dark quantum computing development tunnel.

“Scaling up quantum computers remains a formidable technical challenge that will likely require new physics insights as well as intensive engineering effort over the coming years,” David Lucas, principal investigator of the study from Oxford University, said in a press statement. “Our experiment demonstrates that network-distributed quantum information processing is feasible with current technology.”

Quantum-inspired advancement turns crystal gaps into terabyte storage for classical memory

From punch card-operated looms in the 1800s to modern cellphones, if an object has an “on” and an “off” state, it can be used to store information.

In a computer laptop, the binary ones and zeroes are transistors either running at low or high voltage. On a compact disc, the one is a spot where a tiny indented “pit” turns to a flat “land” or vice versa, while a zero is when there’s no change.

Historically, the size of the object making the “ones” and “zeroes” has put a limit on the size of the storage device. But now, University of Chicago Pritzker School of Molecular Engineering (UChicago PME) researchers have explored a technique to make ones and zeroes out of crystal defects, each the size of an individual atom for classical computer memory applications.

Light-activated Ink Developed to Remotely Control Cardiac Tissue to Repair the Heart

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.

“We showed for the first time that with this optoelectronically active ink, we can print scaffolds that allow remote control of engineered heart tissues,” said co-corresponding author Y. Shrike Zhang, Ph.D., of the Division of Engineering in Medicine at Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system. “This approach paves the way for non-invasive light stimulation, tissue regeneration, and host integration capabilities in cardiac therapy and beyond.”

Three-dimensional bioprinted tissues composed of cells and other body-compatible materials are a powerful emerging tool to repair damaged heart tissue. But most bioprinted tissues cannot generate the necessary electrical activity for cellular function. They must instead rely on invasive wire and electrode placement to control heart activity, which can damage body tissues.