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Category: engineering – Page 4

Engineering high-fidelity tapasin variants to enhance MHC-I antigen presentation

New in JBC press|

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Human leukocyte antigen (HLA) proteins are extremely polymorphic, with different allotypes exhibiting a wide range of dependencies on the chaperone tapasin for peptide loading, expression, and stability at the cell surface. Given its central role in antigen processing, tapasin is frequently downregulated across viral infections and cancers, impairing antigen presentation and hindering the identification of therapeutically relevant peptide antigens. We hypothesized that elucidating the mutational tolerance of tapasin surfaces which mediate interactions with polymorphic HLA residues can provide a means for fine-tuning its chaperoning function and reveal mechanistic epitopes that underlie its function.

How does the most common cause of Alternating Hemiplegia of Childhood (AHC) lead to abnormal repolarization and arrhythmogenesis?

Andrew P. Landstrom & team propose a Ca2+-mediated mechanism in ATP1A3-D801N carriers & identify NCX1 as a possible therapeutic target.

1Department of Cell Biology and.

2Department of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA.

3Department of Biomedical Engineering and.

4Division of Pediatric Neurology and Developmental Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.

3D-printed metamaterials that stretch and fail by design

MIT’s Department of Mechanical Engineering (MechE) offers a world-class education that combines thorough analysis with hands-on discovery. One of the original six courses offered when MIT was founded, MechE faculty and students conduct research that pushes boundaries and provides creative solutions for the world’s problems.

Turmeric and ginger extract may boost implant bonding and kill 92% bacteria

An extract of turmeric and ginger helps bone implants bond strongly while killing bacteria and cancer cells, according to new research from Washington State University with implications for millions of patients with joint replacements and bone cancer. In early tests, the extract roughly doubled bone bonding within six weeks around the implant site, killed more than 90% of bacteria on implant surfaces, and sharply reduced cancer-causing cells. The findings marry elements of a naturopathic approach drawing on traditional medicine with current medical technologies. Turmeric, a golden-orange spice, and ginger root have been used for food and medicinal purposes in China and India for thousands of years.

“Basically, I say it’s combining the best with the latest,” said Susmita Bose, the Westinghouse Distinguished Chair Professor in WSU’s School of Mechanical and Materials Engineering and corresponding author of the paper. “The best part is from the food, and the latest aspect comes from the biomedical device.”

The new study, published in the Journal of the American Ceramic Society, is the most recent work from Bose and Amit Bandyopadhyay, Boeing Distinguished Professor in the School of Mechanical and Materials Engineering, demonstrating that compounds from turmeric and ginger can be effective supplements to cutting-edge medical treatment. That work builds upon their earlier research into the use of 3D printing to produce bone implants, an idea once considered far-fetched that is now a common way to manufacture implants.

Research moves closer to ‘smart’ sensors in knee replacements

If you have a knee replacement, imagine pointing your phone at your knee and pulling up an app that tells you how much stress the artificial joint is experiencing. Knowing the activities that cause the biggest problems—which can lead to a second replacement surgery—would be invaluable. Research led by Binghamton University is closer to making this technology a reality.

Professor Shahrzad “Sherry” Towfighian—a faculty member from the Thomas J. Watson College of Engineering and Applied Science’s Department of Mechanical Engineering—has worked toward “smart-knee” tech over the past decade.

According to the American College of Rheumatology, nearly 800,000 total knee replacements are done every year in the U.S., and that number is expected to rise sharply by 2030 as the population ages and sports injuries become more common.

Breaking fuel cell barriers: New platinum catalyst brings high-efficiency hydrogen vehicles closer to commercialization

A research team has developed a next-generation platinum-based catalyst that improves both activity and durability in hydrogen fuel cells. The study is published in Advanced Materials. The team was led by Professor Sang Uck Lee of the School of Chemical Engineering at Sungkyunkwan University, with Ph.D. candidate Jun Ho Seok as a co-first author and Dr. Sung Chan Cho, in collaboration with Professor Kwangyeol Lee’s team at Korea University and Dr. Sung Jong Yoo’s team at the Korea Institute of Science and Technology (KIST).

Hydrogen fuel cells generate electricity through the electrochemical reaction of hydrogen and oxygen and are considered a promising clean energy technology. However, their broader commercialization has been hindered by the sluggish oxygen reduction reaction (ORR) at the cathode and by catalyst degradation during long-term operation.

Conventional platinum-based intermetallic catalysts are known for their structural stability, but their atomic composition and arrangement are difficult to tune precisely. This has limited efforts to optimize their electronic structure and has made it challenging to achieve both high catalytic activity and long-term durability under demanding operating conditions, such as those required for hydrogen-powered vehicles.

High-throughput platform helps engineer fast-acting covalent protein drugs

A team led by principal investigators Bobo Dang and Ting Zhou at Westlake University/Westlake Laboratory have developed a high-throughput platform for engineering fast-acting covalent protein therapeutics. Their study, titled “A high-throughput selection system for fast-acting covalent protein drugs” published in Science, opens new avenues for next-generation biologics.

Covalent small-molecule drugs have shown great success in cancer therapy by forming irreversible bonds with their targets. This has inspired efforts to extend covalent strategies to protein therapeutics, especially engineered miniproteins. However, their development is limited by a kinetic mismatch: Miniproteins are rapidly cleared in vivo, whereas covalent bond formation is typically slow. In addition, high-throughput platforms for systematically optimizing covalent protein reactivity have been lacking.

To address this challenge, the researchers proposed that precise spatial positioning of chemical warheads within protein scaffolds could enable molecular preorganization, thereby accelerating covalent bond formation without increasing intrinsic reactivity.

Ending the Sun’s Monopoly: The Future of Stellarator Fusion — Brian Berzin, CEO, Thea Energy

“with Brian Berzin — Co-Founder & CEO of Thea Energy.

What if we could build a fusion reactor that runs continuously—without the instability issues that have plagued the field for years?

Brian Berzin is the Co-Founder and CEO of Thea Energy (https://thea.energy/), a next-generation fusion company focused on advancing stellarator technology—one of the most promising but historically underexplored approaches to magnetic confinement fusion.

Brian brings a unique combination of deep technical and financial expertise, with a background spanning electrical engineering, venture capital, private equity, and investment banking.

Prior to founding Thea Energy, Brian served as Vice President of Strategy at General Fusion, where he helped shape commercialization strategy and led engagement with global capital markets during a pivotal period for privately funded fusion.

Continue reading “Ending the Sun’s Monopoly: The Future of Stellarator Fusion — Brian Berzin, CEO, Thea Energy” | >

Stretching metals can tune catalysis: A new method predicts energy shifts

Heterogeneous catalysis—in which catalysts and reactants are of different phases, e.g., solid and gas—is important to many industrial processes and often involves solid metal as the catalyst. Ammonia synthesis, catalytic converters for automobile exhaust, methanol synthesis, carbon dioxide reduction, and hydrogen production are examples of such metal-catalyzed heterogeneous catalysis.

The electronic structure of metal surfaces governs the adsorption of reactants and intermediates, and thus the catalytic activity. For this reason, strain engineering —which tunes the electronic structure of a metal catalyst by stretching or compressing its crystal lattice—has emerged as an important strategy for enhancing catalytic performance. Unfortunately, scientists have not been able to quantify how metal strain influences adsorption energies and reaction barriers across different metal catalysts, thereby limiting the rational design of catalysts with desired properties.

To address this challenge, a research team from the Lanzhou Institute of Chemical Physics (LICP) of the Chinese Academy of Sciences has developed a method to predict how strain modifies adsorption energies and reaction barriers across diverse metal systems. The study is published in the journal Cell Reports Physical Science.

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