CRISPR will get easier and easier to administer. What does that mean for the future of our species?
To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques. These techniques can be applied to mature brain organoids or to the preceding embryoid bodies (EBs) and founding cells. This review will describe techniques used for transient and stable genetic modification of brain organoids and discuss their current use and respective advantages and disadvantages. Transient approaches include adeno-associated virus (AAV) and electroporation-based techniques, whereas stable genetic modification approaches make use of lentivirus (including viral stamping), transposon and CRISPR/Cas9 systems. Finally, an outlook as to likely future developments and applications regarding genetic modifications of brain organoids will be presented.
The development of brain organoids (Kadoshima et al., 2013; Lancaster et al., 2013) has opened up new ways to study brain development and evolution as well as neurodevelopmental disorders. Brain organoids are multicellular 3D structures that mimic certain aspects of the cytoarchitecture and cell-type composition of certain brain regions over a particular developmental time window (Heide et al., 2018). These structures are generated by differentiation of induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) into embryoid bodies followed by, or combined, with neural induction (Kadoshima et al., 2013; Lancaster et al., 2013). In principle, two different classes of brain organoid protocols can be distinguished, namely: (i) the self-patterning protocols which produce whole-brain organoids; and (ii) the pre-patterning protocols which produce brain region-specific organoids (Heide et al., 2018).
Astronomers have identified the earliest pair of quasars, shining 900 million years post-Big Bang, revealing insights into galaxy mergers and the reionization era of the Universe.
An international team of astronomers, including members from the Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), has discovered the earliest known pair of quasars using the Subaru Telescope and Gemini North telescope, both situated on Maunakea in Hawai’i. These quasars, powered by actively feeding supermassive black holes, emit intense radiation. This significant discovery will provide insights into the early evolution of the Universe.
About 400 million to 1 billion years after the Big Bang, something, possibly a combination of sources, unleashed enough radiation to strip the electrons from most of the hydrogen atoms, completely altering the nature of the Universe. Quasars are one potential source of the radiation that caused this “reionization” of the Universe. When matter falls into the supermassive black hole at the center of a galaxy, the matter heats up and releases radiation in a phenomenon known as a quasar.
The Earth’s rotation has been decelerating throughout its history due to tidal dissipation, but the variation of the rate of this deceleration through time has not been established. We present a detailed analysis of eight geological datasets to constrain the Earth’s rotational history from 650 to 240 Mya. The results allow us to test physical tidal models and point to a staircase pattern in the Earth’s deceleration from 650 to 280 Mya. During this time interval, the Earth–Moon distance increased by approximately 20,000 km and the length of day increased by approximately 2.2 h. Specifically, there are two intervals with high Earth rotation deceleration, 650 to 500 Mya and 350 to 280 Mya, separated by an interval of stalled deceleration from 500 to 350 Mya. The interval with stalled deceleration is attributed mainly to reduced tidal dissipation due to the continent-ocean configuration at the time, not to changes in Earth’s dynamical ellipticity from continental assembly or glaciation. Modeling indicates that, except for the very recent time, tidal dissipation is the main driver for decelerating Earth rotation. One potential implication of our findings is that the Earth’s tidal dissipation, along with Earth’s rotation deceleration, may play a role in the evolving Earth.
A new open-access RNA sequencing dataset, MAGE, of 731 individuals across geographically diverse human populations provides a valuable resource to study genetic diversity and evolution and expands the capacity to identify new genetic associations.
Organoids of mammary glands can help researchers more efficiently study lactation, with findings that could apply to fields ranging from agriculture to medicine.
This explores how the human brain forms abstract concepts and adapts to changing environments, specifically looking at how neurons in certain brain regions contribute to complex thinking.
It takes brains to infer how any two things in the world relate to each other, whether it’s the way bad weather links to commuting delays or how environmental conditions lead to the evolution of species. A new study based on recordings in the brains of people has yielded a pathbreaking trove of data that researchers now have used to reveal, with more clarity than ever, the neural incarnations of inferential reasoning.
“Asteroids are leftovers from the planetary formation process, so their compositions vary depending on where they formed in the solar nebula,” said Dr. Anicia Arredondo. “Hydration that is endogenous could suggest that Psyche is not the remnant core of a protoplanet.”
Could a metallic asteroid contain water and what can this teach us about the asteroid’s formation and evolution? This is what a recent study due for publication in the Planetary Science Journal hopes to address as a team of researchers led by the Southwest Research Institute (SwRI) investigated whether the metallic asteroid Psyche —which is one of the largest objects in the main asteroid belt—could contain evidence of water and hydration.
This study holds the potential to help scientists better understand the formation and evolution of asteroids and what this can teach us about the history of the solar system. This study also comes as NASA’s Psyche spacecraft is currently en route to the Psyche asteroid and is scheduled to arrive in August 2029.
Continue reading “Webb Telescope Unveils Evidence of Water and Hydration on Asteroid Psyche” »
UNIVERSITY PARK, Pa. — A new study has rewritten the conventionally understood evolutionary history of certain proteins critical for electrical signaling in the nervous system. The study, led by Penn State researchers, shows that the well-studied family of proteins — potassium ion channels in the Shaker family — were present in microscopic single cell organisms well before the common ancestor of all animals. This suggests that, rather than evolving alongside the nervous system as previously thought, these ion channels were present before the origin of the nervous system.
The study appeared in the Proceedings of the National Academy of Sciences.
“We tend to think of evolution as a one-way march toward greater and greater complexity, but that often isn’t what occurs in the natural world,” said Timothy Jegla, associate professor of biology in the Penn State Eberly College of Science and leader of the research team. “For example, it was thought that as different kinds of animals evolved and the nervous system became more complex, ion channels arose and diversified to match that complexity. But our research suggests that this is not the case. We have previously shown that the oldest living animals, those with simple nerve nets, have the highest ion channel diversity. This new finding adds to growing evidence that many of the building blocks for the nervous system were already in place in our protozoan ancestors — before the nervous system even existed.”
