Lifeboat Foundation

#microbiome

The microbiota can influence host behaviour through the gut–brain axis. In this Opinion, Johnson and Foster explore the evolution of this relationship and propose that adaptations of competing gut microorganisms may affect behaviour as a by‑product, leading to host dependence.

The idea that intelligence can differ between populations has made headlines again, but the rules of evolution make it implausible.

Kevin Mitchell

Associate professor of genetics and neuroscience at Trinity College Dublin.

Continue reading “Why genetic IQ differences between ‘races’ are unlikely” »

3 days left to get into our Initial Community Offering (ICO) for the evolution of the blockchain which I’ve invested and advising.

Welcome to the Holo ICO whitelist registration! You will need to verify your identity and join the whitelist before you can participate in the ICO. The process requires creating an account, completing a quick identity verification, and then adding your Ethereum address to our whitelist. Once whitelisted, your address will be written into our smart contract, and you will be prepared to participate in the Holo ICO.

NOTE: If you are a resident or citizen of the United States, China, or South Korea, you cannot participate in our ICO due to legal and regulatory uncertainty in those jurisdictions. You will be unable to verify or whitelist if you are a resident or citizen of one of these countries.

To learn more about our ICO, visit https://holo.host/ico

Ignored for 30 years after its discovery, this archaic baleen whale finally gets a place in the spotlight.

A whale fossil unearthed three decades ago in New Zealand’s South Canterbury district has led to an unexpected find that rewrites the history of whale evolution, National Geographic reports.

The fossil dates back 27 million years ago and was identified as a previously unknown genus of baleen whale.

Continue reading “27-Million-Year-Old Fossil Found In New Zealand Helps Identify World’s Oldest Known Baleen Whale” »

We talk to Mark O’Connell about transhumanism, the evolution of the human species and his Wellcome Book Prize-shortlisted book To Be A Machine.

Advocates of transhumanism face a similar choice today. One option is to take advantage of the advances in nanotechnologies, genetic engineering and other medical sciences to enhance the biological and mental functioning of human beings (never to go back). The other is to legislate to prevent these artificial changes from becoming an entrenched part of humanity, with all the implied coercive bio-medicine that would entail for the species.

We can either take advantage of advances in technology to enhance human beings (never to go back), or we can legislate to prevent this from happening.

Continue reading “Transhumanism: advances in technology could already put evolution into hyperdrive – but should they?” »

Researchers have identified a protein that is different between healthy and cancerous cells, offering a potential target for therapeutic interventions.

Abstract

Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation of cargoes to the trans-Golgi network (TGN). Here we report the solution structure of full length human SNX3, and show that PI3P recognition is accompanied by bilayer insertion of a proximal loop in its extended Phox homology (PX) domain. Phosphoinositide (PIP) binding is completely blocked by cancer-linked phosphorylation of a conserved serine beside the stereospecific PI3P pocket. This “PIP-stop” releases endosomal SNX3 to the cytosol, and reveals how protein kinases control membrane assemblies. It constitutes a widespread regulatory element found across the PX superfamily and throughout evolution including of fungi and plants.

Continue reading “A Protein that Shows the Difference Between Cancer and Non-cancer Cells” »

Ann Donnelly was utterly confused the first time she examined her protein. On all counts, it behaved like an enzyme—a protein catalyst that speeds up biological reactions in cells. One could argue that enzymes, sculpted by eons of evolution, make life possible.

There was just one problem: her protein wasn’t evolved. It wasn’t even “natural.” It was, in fact, a completely artificial construct made with random sequences of DNA—something that’s never existed in nature before.

Donnelly was looking at the first artificial enzyme. An artificial protein that, by all accounts, should not be able to play nice with the intricate web of biochemical components and reactions that support life.

Continue reading “Enzyme Designed Entirely From Scratch Opens a World of Biological Possibility” »

There’s an unsettling premise at the heart of Joe Brewer’s life’s work.

Brewer is a change strategist dedicated to ensuring a thriving global civilization exists 100 years from now—and he believes this is becoming less likely every year. There’s rising instability in our fragile and rapidly changing biosphere, he says, and society is unlikely to escape harm.

“We are going through a period of planetary change, and there is a collapse dynamic that’s already happening. The global scale social complexity we have today is at risk, and we may lose it,” he told me in a conversation for Singularity Hub.

Continue reading “How ‘Cultural Evolution’ Can Give Us the Tools to Build Global-Scale Resilience” »