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An international team of researchers used multi-wavelength observations of active galactic nuclei to study how black holes launch relativistic jets. The sixteen sources were observed with the Event Horizon Telescope during its first campaign in 2017. The extreme resolution achieved by the Event Horizon Telescope enabled studies of jets closer than ever to the central supermassive black holes of these galaxies.
The team investigated the acceleration and magnetization of the jets by comparing results obtained at various frequencies and angular scales. The work was led by scientists from the MPIfR in Bonn, Germany, and the IAA-CSIC in Granada, Spain, and is now published in Astronomy & Astrophysics.
To assess the accuracy in understanding the evolution of jets in the centers of active galaxies with supermassive black holes, an international research team led by Jan Röder (MPIfR and IAA-CSIC) compared observations made with the Event Horizon Telescope with previous studies using the Very Long Baseline Array and the Global Millimeter VLBI Array, which probe much larger spatial scales.
Posted in biotech/medical, evolution, genetics | Leave a Comment on Genetic diversity and molecular evolution of 3-carboxymuconate cyclase (Gp60–70), the major antigen in pathogenic Sporothrix species
Sporotrichosis, a neglected tropical disease caused by Sporothrix species, is a growing concern, particularly due to the emergence of highly virulent, cat-transmitted S. brasiliensis. Rapid diagnosis and surveillance are crucial for controlling sporotrichosis. This study investigated the 3-carboxymuconate cyclase (CMC) gene, which encodes the major Sporothrix antigen (Gp60–70), as a molecular marker to understand the genetic diversity and evolution of these fungi. Analysis of 104 isolates (S. brasiliensis, S. schenckii, S. globosa, and S. luriei) revealed 79 unique haplotypes, demonstrating superior discriminatory power over traditional molecular markers. High–CMC polymorphisms, especially in S. brasiliensis and S. schenckii, suggest recent population expansion or positive selection, potentially driven by environmental pressures such as polyaromatic hydrocarbon pollutants. The conserved chromosomal location of CMC in pathogenic Sporothrix and its absence in less virulent species suggest a role in virulence. Identifying conserved residues within predicted B-cell epitopes provides targets for diagnostics and therapeutics. Additionally, we identified N-linked glycosylation sequons (e.g. NGS at 62, NNT at 225, and NGT at 373/374) conserved in pathogenic Sporothrix but absent in environmental Sordariomycetes, possibly contributing to pathogenicity and niche adaptation. This study establishes CMC as a valuable marker for understanding Sporothrix evolution and virulence, aiding in sporotrichosis management.
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Using the Green Bank Telescope (GBT), astronomers have detected a new giant molecular cloud in the Milky Way galaxy. The newfound cloud has a size of nearly 200 light years and its mass is estimated to be some 160,000 solar masses. The finding was reported in a paper published March 18 on the arXiv preprint server.
Molecular clouds are huge complexes of interstellar gas and dust left over from the formation of galaxies, composed mostly of molecular hydrogen. Molecular clouds with masses greater than 100,000 solar masses are called giant molecular clouds (GMCs). In general, GMCs are 15–600 light years in diameter and are the coldest and densest parts of the interstellar medium.
GMCs are gas reservoirs where most star formation takes place. Therefore, studying their lifecycle and characteristics is crucial to advancing our knowledge about the formation and evolution of galaxies.
A deadly fungal epidemic in Brazil is evolving fast: pollution, cats, and genetics may be fueling its unstoppable spread.
Brazil is facing the world’s largest and most persistent sporotrichosis epidemic, a fungal infection spread primarily through cats. A new study reveals an alarming genetic diversity in the fungus, suggesting that urban pollutants may be accelerating its evolution. Researchers identified molecular markers that could enhance diagnostics and treatments, while also highlighting the rapid adaptation and virulence of Sporothrix brasiliensis.
Unraveling the Largest Sporotrichosis Epidemic.
Consciousness is one of the most fundamental aspects of our existence, but it remains barely understood, even defined. Across the world scholars of many disciplines — philosophy, science, social science, theology — are joined on a quest to understand this phenomenon.
Tune into one of the more original and controversial thinkers at the forefront of consciousness research, Stuart Hameroff, as he presents his ideas. Hameroff is an anaesthesiologist who, alongside Roger Penrose, proposes that the source of consciousness is structural, produced from a certain shape in our brain. He expands on this, and much more (such as evolution), in this talk. Have a listen!
To witness such topics discussed live buy tickets for our upcoming festival: https://howthelightgetsin.org/festivals/
In the 1930s, researchers first noticed oddities in how galaxies moved, suggesting something invisible exerted gravitational pull. Decades later, studies of the cosmic microwave background —the lingering radiation from the universe’s birth—confirmed dark matter’s importance in shaping cosmic evolution.
A pivotal study by the Planck Collaboration in 2018 revealed that dark matter makes up roughly 27% of the universe’s total energy. By comparison, ordinary matter—the stuff of planets, stars, and us—accounts for only 5%.
Scientists have spent decades trying to understand what dark matter might be. Supersymmetry, a popular theory in particle physics, proposes a “partner” particle for every known particle, potentially offering clues about dark matter’s identity.
Researchers discovered uniquely human neuroanatomical features in a study comparing human brains to macaque and chimpanzee brains.
A groundbreaking study reveals that what makes humans unique isn’t just intelligence but also emotional and social cognition. Comparing brain scans of humans, chimpanzees, and macaques, researchers found that key brain connections related to emotions and social interactions are distinctly human, highlighting the deep-rooted role of relationships in human evolution.
What makes the human brain unique?
A terrifying glimpse at one potential fate of our Milky Way galaxy has come to light thanks to the discovery of a cosmic anomaly that challenges our understanding of the universe.
An international team of astronomers led by CHRIST University, Bangalore, found that a massive spiral galaxy almost 1 billion light-years away from Earth harbors a supermassive black hole billions of times the sun’s mass which is powering colossal radio jets stretching 6 million light-years across.
That is one of the largest known for any spiral galaxy and upends conventional wisdom of galaxy evolution, because such powerful jets are almost exclusively found in elliptical galaxies, not spirals.
Scientists uncovered a key genetic pathway in the origin of feathers, but they found that evolution is stubborn in turning back the clock.
