Lifeboat Foundation

A new UC Davis-led study sheds light on cell type-specific biomarkers, or signs, of melanoma. The research was recently published in the Journal of Investigative Dermatology.

Melanoma, the deadliest of the common skin cancers, is curable with early diagnosis and treatment. However, diagnosing melanoma clinically and under the microscope can be complicated by what are called melanocytic nevi—otherwise known as birth marks or moles that are non-cancerous. The development of melanoma is a multi-step process where “melanocytes,” or the cells in the skin that contain melanin, mutate and proliferate. Properly identifying melanoma at an early stage is critical for improved survival.

“The biomarkers of early melanoma evolution and their origin within the tumor and its microenvironment are a potential key to early diagnosis of melanoma,” said corresponding author of the study Maija Kiuru, associate professor of clinical dermatology and pathology at UC Davis Health. “To unravel the mystery, we used high-plex spatial RNA profiling to capture distinct gene expression patterns across cell types during melanoma development. This approach allows studying the expression of hundreds or thousands of genes without disrupting the native architecture of the tumor.”

Australopithecus fossils in South Africa are one million years older than initially thought. This could rewrite the story of human evolution.

The motion of a tiny number of charged particles may solve a longstanding mystery about thin gas disks rotating around young stars, according to a new study from Caltech.

These features, called accretion disks, last tens of millions of years and are an early phase of solar system evolution. They contain a small fraction of the mass of the star around which they swirl; imagine a Saturn-like ring as big as the solar system. They are called accretion disks because the gas in these disks spirals slowly inward toward the star.

Continue reading “Why does inside of solar system not spin faster? Old mystery has possible new solution” »

NLM’s NCBI is introducing the Comparative Genome Viewer (CGV), an easy-to-use visualization tool that helps you quickly compare eukaryotic genome assemblies and easily identify genomic changes that may be significant to biology and evolution. With the new CGV you can view and compare the alignment between two assemblies to see differences in genomic sequence and structure, including deletions, inversions, and translocations. Currently, you can compare assemblies from over 50 annotated animal and plant genomes.

In a trio of studies published on June 27 in the journal Nature Microbiology 0, researchers at The University of Texas at Austin have discovered “fingerprints” of mysterious viruses hidden in an ancient group of microbes that may include the ancestors of all complex life on Earth: from fungi to plants to humans.

Ths discovery is significant; it explores the hypothesis that viruses were imperative to the evolution of humans and other complex life forms.

These microbes – known as Asgard archaea after the abode of the gods in Norse mythology – are usually found in the frigid sediments deep in the ocean and in boiling springs, and existed on Earth before the first eukaryotic cells, which carry their DNA inside a nucleus.

Cosmologist, noted author, Astronomer Royal and recipient of the 2015 Nierenberg Prize for Science in the Public Interest Lord Martin Rees delivers a thought-provoking and insightful perspective on the challenges humanity faces in the future beyond 2050. [3/2016] [Show ID: 30476]

Frontiers of Knowledge.
(https://www.uctv.tv/frontiers-of-knowledge)

Continue reading “Looking Beyond 2050 — On Earth and in Space with Lord Martin Rees” »

Researchers at North Carolina State University show that an important gene in maize called HPC1 modulates certain chemical processes that contribute to flowering time, and has its origins in “teosinte mexicana,” a precursor to modern-day corn that grows wild in the highlands of Mexico. The findings provide insight into plant evolution and trait selection, and could have implications for corn and other crops’ adaptation to low temperatures.

“We are broadly interested in understanding how natural variation of lipids are involved in the growth and development of plants, and how these compounds may help plants adapt to their immediate environments,” said Rubén Rellán-Álvarez, assistant professor of structural and molecular biochemistry at NC State and the corresponding author of a paper describing the research. “Specifically, we wanted to learn more about variation in lipids called phospholipids, which consist of phosphorus and fatty acids, and their role in adaptation to cold, low phosphorus, and the regulation of important processes for plant fitness and yield like flowering time.”

Maize grown at higher altitudes, like the highlands of Mexico, needs special accommodations in order to grow successfully. The colder temperatures in these mountainous regions put maize at a slight disadvantage when compared with maize grown at lower elevations and higher temperatures.

New research suggests that Darwinian evolution could be happening up to four times faster than previously thought, based on an analysis of genetic variation.

The more genetic differences there are in a species, the faster evolution can happen, as certain traits die off and stronger ones get established. The team behind this latest study calls it the “fuel of evolution”, and they looked at data on 19 different wild animal groups around the world.

That data analysis revealed this raw material for evolution is more abundant than earlier estimates, and as a result we may have to adjust our expectations for how quickly animals evolve – a pertinent question in our age of climate change.

The ability to change your mind is a key part of being a social creature. Reasoning by oneself is a shallow endeavor.