Archive for the ‘evolution’ category: Page 7

Jun 13, 2020

From bacteria to you: The biological reactions that sustain our rhythms

Posted by in categories: biotech/medical, chemistry, evolution

Every second of every day, countless biochemical reactions take place in our bodies’ cells. The organization of this complex system is the result of billions of years of evolution, fine-tuning our functions since the first primordial organisms.

One such vital reaction is “methylation,” where a —a carbon atom linked to three hydrogen atoms—attaches itself to a target molecule. Methylation is involved in the regulation of everything from DNA to proteins, and it is so vital that it can be found in all .

In a recent paper published in Communications Biology, a team of researchers lead by Jean-Michel Fustin and Hitoshi Okamura from Kyoto University’s Graduate School of Pharmaceutical Sciences has uncovered an intimate connection between methylation and the body’s circadian rhythms: a link that exists even in organisms that don’t traditionally “sleep,” such as bacteria.

Jun 11, 2020

Physicists perform the most detailed simulation of the Universe yet

Posted by in categories: cosmology, evolution, particle physics, singularity

Circa 2019 o,.0.

How did the universe evolve from a point of singularity, known as the Big Bang, into a massive structure whose boundaries seem limitless? New clues and insight into the evolution of the universe have recently been provided by an international team of physicists, who performed the most detailed large-scale simulation of the universe to date.

The researchers made their own universe in a box — a cube of space spanning more than 230 million light-years across. Previous cosmological simulations were either very detailed but spanned a small volume or less detailed across large volumes. The new simulation, known as TNG50, managed to combine the best of two worlds, producing a large-scale replica of the cosmos while, at the same time, allowing for unprecedented computational resolution.

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Jun 11, 2020

Squid and octopus can edit and direct their own brain genes

Posted by in categories: biotech/medical, evolution, genetics, neuroscience

Circa 2017

Unlike other animals, cephalopods – the family that includes octopuses, squid and cuttlefish – do not obey the commands of their DNA to the letter.

Instead, they sometimes interfere with the code as it is being carried by a molecular “messenger”. This has the effect of diversifying the proteins their cells can produce, leading to some interesting variations.

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Jun 9, 2020

Have humans reached the end of evolution? Not under these 4 scenarios

Posted by in categories: biotech/medical, education, evolution, transhumanism

3. Evolution shifts to off-world human colonies.

4. Transhumanism will drive evolution.

Is natural selection still a major force in human evolution? As far back as high school biology, we’ve been taught to think the answer must be yes. But is it really true?

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Jun 7, 2020

Exploring the Evolution of the Human Brain at the Single-cell Level

Posted by in categories: evolution, neuroscience

Oligodendrocytes and astrocytes displayed more differences in the human evolutionary lineage than neurons as compared to similar cells in other primates. Credit: Pavel Odinev/ Skoltech.

Jun 2, 2020

A plague of magnetic spots among the hot stars of globular clusters

Posted by in categories: chemistry, cosmology, evolution

For more than six decades, the quest to understand the formation of hot (about 20,000−30,000 K) extreme horizontal branch (EHB) stars in Galactic globular clusters has remained one of the most elusive in stellar evolutionary theory. Here we report on two discoveries that challenge the idea of the stable luminosity of EHB stars. The first mode of EHB variability is periodic and cannot be ascribed to either binary evolution or pulsation. Instead, we attribute it here to the presence of magnetic spots: superficial chemical inhomogeneities whose projected rotation induces the variability. The second mode of EHB variability is aperiodic and manifests itself on timescales of years. In two cases, six-year-long light curves display superflare events that are several million times more energetic than solar analogues. We advocate a scenario in which the two EHB variability phenomena are different manifestations of diffuse, dynamo-generated, weak magnetic fields. Magnetism is therefore a key player driving the formation and evolution of EHB clusters stars and, likewise, operating in the Galactic field counterparts. Our conclusions bridge similar variability/magnetism phenomena in all radiative-enveloped hot-stars: young main-sequence stars, old EHBs and defunct white dwarfs.

Jun 2, 2020

Annihilation of all Yardsticks — essay on Wittgenstein’s thoughts about certainty

Posted by in categories: aging, evolution, futurism, health, human trajectories, life extension, mathematics, philosophy, robotics/AI

How do we know what to do in life? How do we know where to go, where to start, where we are, what it’s all made of, why it matters? Why don’t we know? Can we know? Why am I alive? What is alive? Why is this place here? What is going on?

In his collection of papers and notes posthumously published as a book in 1969, titled On Certainty, Ludwig Wittgenstein writes, “How does someone judge which is his right and which his left hand?” We are certain that we know, but we really don’t know the answer. “At the foundation of well-founded belief lies belief that is not founded.” He serendipitously illustrated his point from beyond the grave when he wrote: “‘But is there then no objective truth? Isn’t it true, or false, that someone has been on the moon?’ If we are thinking within our system, then it is certain that no one has ever been on the moon. Not merely is nothing of the sort ever seriously reported to us by reasonable people, but our whole system of physics forbids us to believe it.“ We only have the ability to examine a minuscule fraction of the information available in the big picture of it all. We cannot escape uncertainty yet, even though we routinely pretend that we have.

The book talks about “language games”. It’s a concept that Wittgenstein developed earlier in his life to explain how people inherit and subconsciously create unspoken rules of communication that gloss over or emphasize certain words and ideas. He writes, “It’s not a matter of [philosopher G.E.] Moore’s knowing that there’s a hand there, but rather we should not understand him if he were to say ‘Of course I may be wrong about this.’ ” We don’t say we know that our religious, political or even sports affiliations are true, the assumptions are built right into our languaging. What better example is there than the wide-eyed sports fan who is unquestionably convinced that their random group of players is the best that there ever was and will be? Many of them are not bluffing, their language game has programmed them. The word structure that they know will not allow them to see it any other way. People’s various language games assume what they want, often from habit, usually based on subconscious tradition.

“Suppose now I say ‘I’m incapable of being wrong about this: that is a book’ while I point to an object. What would a mistake here be like? And have I any clear idea of it?” There are fake books, tricks are played, there are mind altering substances, coincidences happen, there could be a secret society of magicians controlling public perceptions, or our world could be some kind of solipsistic melting pot of dreams and hallucinations. We could list things like these all day. There are simpler examples for common situations as well, like, somebody might be unquestionably convinced they are seeing a magazine when it is a zine, or a cow when it is in fact a bull. It’s also pretty common for people to think that they know a person made a mistake that they did not actually make. Consider that the way the future is headed, there is a good chance we will all have 3d printers that run on practically free energy and make everything out of basic materials like sand and vegetation, be free to travel around the universe with access to trillions of planets, and so forth. In that reality, theme planets are all but inevitable. There will be planets for specific ecological niches and time periods. People will be able to set up Plato’s Cave, Truman Show style planets, and countless other scenarios. Being that this seems so inevitable (read The Singularity is Near if you are not convinced), why would we assume that we are not in a scenario like that right now?

What happens though, is if we were to take the groundlessness of surety into account in our day to day communication, we wouldn’t be able to say anything. It seems we might almost be cornered into adopting language games. “This game proves its worth. That may be the cause of its being played, but it is not the ground.” The temptation to stay locked into them is almost irresistible, especially the hereditary ones. “[W]ould it be unthinkable that I should stay in the saddle however much the facts bucked?” It isn’t unthinkable because the entire purpose of the game is to ride unreasonable broncos and we have been training since we were born. Wittgenstein goes on to ponder, “Certain events would [put] me into a position in which I could not go on with the old language-game any further. In which I was torn away from the sureness of the game. Indeed, doesn’t it seem obvious that the possibility of a language-game is conditioned by certain facts?” It’s possible but usually very difficult because safeguards and defense mechanisms are built into them too. When a person does something detrimental, “it is what it is” — when evidence bucks, faith grips tighter — another team might have won the super bowl, but their quarterback threw for more yards in the season.

There are a lot of incompatible language games being played around the world. If you tell a person embedded in another one that they are wrong, it’s almost as if they cannot know it because if they were to consider that they should doubt parts of it, it would open the door to the slippery slope leading to the “annihilation of all yardsticks”, and it is difficult, maybe nearly impossible, to live in a world without them. “If something happened calculated to make me doubtful of my own name, there would certainly also be something that made the grounds of these doubts themselves seem doubtful, and I could therefore decide to retain my old belief.” In order to take action, you have to make decisions, and in order to make decisions, some of the patterns in your mind need to win out over the others. If there aren’t any execute commands in the code, then the code is lifeless and goes nowhere.

Does this mean that we have to permit some unsubstantiated assertions? All of them? Do we have the right to dismiss any of them? If it turns out to be true that there is no foundation for knowledge or contemplation, then how could we draw such a line? I think a lot of it comes down to what I talk about in terms of how much we are willing to bet at a given time, and the use of words like “seems”. “We just do not see how very specialized the use of ‘I know’ is. For ‘I know’ seems to describe a state of affairs which guarantees what is known, guarantees it as a fact. One always forgets the expression ‘I thought I knew’ “.
It’s not that we know, it’s that certain things look very likely to us from our current perspective, and we all know that our perspectives have changed, and therefore that more of them will likely change as well. We should learn to expect this, and if we are honest with ourselves, be proactive about it. I believe that is the common language game we can all play. It is like we are trying to play blackjack with people who are trying to play poker, war, concentration and rummy with us. If we all played poker, our individual bets would still range in scale depending on our hands at any given time but we would all be playing a compatible game.

When it comes to the concept of “seems”, I have found that there doesn’t seem to be a lot of alternatives, which sometimes makes it difficult to talk in terms of it in a stylistically appropriate way. Being that people are prone to asserting the uncertain so pervasively, it makes sense that we might end up with so few words for expressing variations and shades of doubt. Wittgenstein uses a variety of phrasing throughout the book that give us some ideas on how we might expand it. I pulled many of them together and summed them up:

“Suppose I replaced Moore’s ‘I know’ by ‘I am of the unshakeable conviction’?”
“It stands fast for me and many others…”
‘That’s how it is — rely upon it.’
“I learned it years and years ago”
“I am sure it is so.“
“is an irreversible belief.“
“it gives us a right to assume it.”
“Suppose it were forbidden to say ‘I know’ and only allowed to say ‘I believe I know’?”
“excludes a certain kind of failure”
“I can hardly be mistaken”
“That is the truth — so far as a human being can know it.“

That is not to say that every communication should necessarily be tentative. One of the main conclusions that Wittgenstein reaches is that our beliefs can be justified, but not certain. “[…] I find it quite correct for someone to say ‘Rubbish!’ and so brush aside the attempt to confuse him with doubts at bedrock, — nevertheless, I hold it to be incorrect if he seeks to defend himself (using, e.g., the words ‘I know’).” I think of that in terms of calculated risk. Sometimes you have to remove the language of doubt in order to favor the patterns in life that seem most important. That, though, is less like certainty and more like leadership. All confidence is either bluff or ignorance. If we have calculated the potential value in bluffing our certainty, that is one thing, but to do it blindly, unknowingly, is another.

Wittgenstein talks about how if existential certainty is there to be found, it would probably be in a form similar to a mathematical proposition and proof. “If the proposition 12×12=144 is exempt from doubt, then so too must non-mathematical propositions be.” “If” being a key word there. He reminds us that it seems as though they cannot be certain either but goes out on a short limb to humor that they are. In that process he makes what I find to be one of the most profound and rather Godel-esque insights of the book: ”there ought to be a proposition that is just as certain, and deals with the process of this calculation, but isn’t itself mathematical. I am thinking of such a proposition as: ‘The multiplication 12×12, when carried out by people who know how to calculate, will in the great majority of cases give the result 144.’ Nobody will contest this proposition, and naturally it is not a mathematical one.” That might be a key to extinguishing existential angst and establishing the foundation of common meaning.

It is true that the universe might be infinite and that even if it isn’t, the work to reach certainty might still end up being like trying to reach zero by continuously dividing by half, always inching closer, impossible to reach. In the meantime, we wait in suspense as patterns wind their way through the chaos like armies meandering through mine fields. Certainty is no more than the soldiers out ahead who haven’t been blown up yet, standing in the middle of the field with a universe of unknown mines ahead. Some evolutionary lineages successfully walk on for hundreds of millions of years before they are blown up and consumed by the blur. What choice do we have, what else might we do, use patterns we don’t understand or that are wrong more of the time? We don’t know if we will make it or not. Maybe it is too difficult. Maybe it will take a hundred million additional years. Maybe we are in the home stretch and artificial intelligence of the near future is the calculator of existential proofs. We just don’t know.

We don’t know how long it might take to get a better grip on the nature of certainty, and death is barreling down on us, hence the movement for indefinite life extension. It is tragic to be uncertain about everything, which includes our own wants and needs, when the stakes are so high. It is tragic to live and die as a captive in a dark basement. Earth is that basement and our lifespans are the walls. Some people don’t see that, like captives of Plato’s cave.

As things stand, the best we can do is be willing to make educated bets at any given time. The only thing we know for sure is that we don’t know anything for sure. We don’t even know if we don’t know. That is good news though, therein sneaks the foundation that begins to unravel the absurd. If the only thing we know is that nothing makes sense until we know, and that by working to figure stuff out, we could end up knowing, that small patch of philosophical ground in the quicksands of uncertainty becomes the launchpad upon which we begin stringing lines of certainty together. Anything else would be illogical, against our nature, detrimental to our fitness. Standing on this platform is a stage in our evolutionary trajectory.

“We all believe that it isn’t possible to get to the moon; but there might be people who believe that that is possible and that it sometimes happens. We say: these people do not know a lot that we know. And, let them be never so sure of their belief — they are wrong and we know it. If we compare our system of knowledge with theirs then theirs is evidently the poorer one by far.”

Jun 1, 2020

Evolution of coronavirus outlines path from animals to humans

Posted by in categories: biotech/medical, evolution, genetics

Summary: Study reports SARS-CoV-2, the virus that causes COVID-19, was well suited to making the jump from animals to humans by shapeshifting as it gained the ability to infect human cells. The virus’s ability to infect humans occurred via exchanging gene fragments from a coronavirus that infected pangolins. The species-to-species transmission was a result of the ability of SARS-CoV-2 to bind to host cells through alterations to its genetic material.

Source: Duke University

A team of scientists studying the origin of SARS-CoV-2, the virus that has caused the COVID-19 pandemic, found that it was especially well-suited to jump from animals to humans by shapeshifting as it gained the ability to infect human cells.

May 29, 2020

A giant galaxy in the young Universe with a massive ring

Posted by in categories: evolution, space

In the local (redshift z ≈ 0) Universe, collisional ring galaxies make up only ~0.01% of galaxies1 and are formed by head-on galactic collisions that trigger radially propagating density waves2,3,4. These striking systems provide key snapshots for dissecting galactic disks and are studied extensively in the local Universe5,6,7,8,9. However, not much is known about distant (z 0.1) collisional rings10,11,12,13,14. Here we present a detailed study of a ring galaxy at a look-back time of 10.8 Gyr (z = 2.19). Compared with our Milky Way, this galaxy has a similar stellar mass, but has a stellar half-light radius that is 1.5–2.2 times larger and is forming stars 50 times faster. The extended, diffuse stellar light outside the star-forming ring, combined with a radial velocity on the ring and an intruder galaxy nearby, provides evidence for this galaxy hosting a collisional ring. If the ring is secularly evolved15,16, the implied large bar in a giant disk would be inconsistent with the current understanding of the earliest formation of barred spirals17,18,19,20,21. Contrary to previous predictions10,11,12, this work suggests that massive collisional rings were as rare 11 Gyr ago as they are today. Our discovery offers a unique pathway for studying density waves in young galaxies, as well as constraining the cosmic evolution of spiral disks and galaxy groups.

May 25, 2020

Dr. Michael R. Rose presents “Biological Immortality is REAL”

Posted by in categories: biological, education, evolution, life extension

Dr. Michael R. Rose is Professor at Department of Ecology and Evolutionary Biology at University Of California, Irvine. His main area of work has been the evolution of aging.
“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov

We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.

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