Scientists have recently reviewed the available literature to examine the critical roles played by mitochondria in maintaining homeostasis. The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases. This review has been published inExperimental & Molecular Medicine.
Mitochondria is a cytoplasmic organelle in most eukaryotic cells and is enclosed by two phospholipid membranes: the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM). These membranes separate functionally compartmentalized structures, i.e., matrix and intermembrane space. Mitochondria contain a unique genetic code, mitochondrial DNA (mtDNA).
During evolution, most mitochondrial genes were lost or translocated to nuclei. However, genes that remained in mtDNA encode for essential translational apparatus, i.e., ribosomal RNAs and transfer RNAs. In addition, these genes also encode proteins that are key components of oxidative phosphorylation system (OXPHOS) complexes embedded in the IMM.
Michael Levin, a developmental biologist at Tufts University, challenges conventional notions of intelligence, arguing that it is inherently collective rather than individual.
Levin explains that we are collections of cells, with each cell possessing competencies developed from their evolution from unicellular organisms. This forms a multi-scale competency architecture, where each level, from cells to tissues to organs, is solving problems within their unique spaces.
Levin emphasizes that properly recognizing intelligence, which spans different scales of existence, is vital for understanding life’s complexities. And this perspective suggests a radical shift in understanding ourselves and the world around us, acknowledging the cognitive abilities present at every level of our existence.
How would it feel to control objects with your mind? Or hear colors? Or maybe even live forever? Well, if you want to find out, all you have to do is become a cyborg. How would being part machine affect us? Would it cause a greater divide between the rich and the poor? And is this the next step in human evolution?
What happened before the Big Bang? In two of our previous films we examined cyclic cosmologies and time travel universe models. Specially, the Gott and Li Model https://www.youtube.com/watch?v=79LciHWV4Qs) and Penrose’s Conformal Cyclic Cosmology https://www.youtube.com/watch?v=FVDJJVoTx7s). Recently Beth Gould and Niayesh Afshordi of the Perimeter Institute for Theoretical Physics have fused these two models together to create a startling new vision of the universe. In this film they explain their new proposal, known as Periodic Time Cosmology.
0:00 Introduction. 0:45 NIayesh’s story. 1:15 Beth’s story. 2:25 relativity. 3:26 Gott & Li model. 6:23 origins of the PTC model. 8:17 PTC periodic time cosmology. 10:55 Penrose cyclic model. 13:01 Sir Roger Penrose. 14:19 CCC and PTC 15:45 conformal rescaling and the CMB 17:28 assumptions. 18:41 why a time loop? 20:11 empirical test. 23:96 predcitions. 26:19 inflation vs PTC 30:22 gravitational waves. 31:40 cycles and the 2nd law. 32:54 paradoxes. 34:08 causality. 35:17 immortality in a cyclic universe. 38:02 eternal return. 39:21 quantum gravity. 39:57 conclusion.
Elizabeth Gould has asked to make this clarification in the written text ” “Despite the availability of infinite time in the periodic time model, this doesn’t lead to thermalization in a typical time-evolution scenario, and therefore doesn’t, strictly speaking, solve the problem related to thermalization in the power spectrum. The reason for this is that, unlike bounce models with a net expansion each cycle, our model has an effective contraction during the conformal phases. Periodic time, therefore, has a unique character in which it reuses the power spectrum from the previous cycles, which is confined to a given form due to the constraints of the system, rather than removing the old power spectrum and needing to produce a new one.”
Our lifespans might feel like a long time by human standards, but to the Earth it’s the blink of an eye. Even the entirety of human history represents a tiny slither of the vast chronology for our planet. We often think about geological time when looking back into the past, but today we look ahead. What might happen on our planet in the next billion years?
Written and presented by Prof David Kipping, edited by Jorge Casas.
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Does our increasing dependency on technology diminish our human potential? In this episode, visionary scientist Gregg Braden discusses the current transhuman movement – the merging of technology and human biology, often referred to as the singularity. He describes three levels of tech integration where the final level replaces our natural biology. In a time of rapid evolution, reflection and discernment are key. Braden highlights what we can do to release the conditioning of a technology-dependent society and how to follow the natural rhythms within ourselves.
Michael Levin, a developmental biologist at Tufts University, challenges conventional notions of intelligence, arguing that it is inherently collective rather than individual.
Levin explains that we are collections of cells, with each cell possessing competencies developed from their evolution from unicellular organisms. This forms a multi-scale competency architecture, where each level, from cells to tissues to organs, is solving problems within their unique spaces.
Levin emphasizes that properly recognizing intelligence, which spans different scales of existence, is vital for understanding life’s complexities. And this perspective suggests a radical shift in understanding ourselves and the world around us, acknowledging the cognitive abilities present at every level of our existence.
An ancient relative of modern seals—known as Potamotherium valletoni—that had an otter-like appearance and lived over 23 million years ago likely used its whiskers to forage for food and explore underwater environments, according to a new study in Communications Biology. The findings provide further insight into how ancient seals transitioned from life on land to life underwater.
Although modern seals live in marine environments and use their whiskers to locate food by sensing vibrations in the water, ancient seal relatives mostly lived on land or in freshwater environments. Some species used their forelimbs to explore their surroundings. Prior to this study, it was unclear when seals and their relatives began using their whiskers to forage.
Alexandra van der Geer and colleagues investigated the evolution of whisker-foraging behaviors in seals by comparing the brain structures of Potamotherium with those of six extinct and 31 living meat-eating mammals, including mustelids, bears, and seal relatives. Brain structures were inferred from casts taken from the inside of skulls.
The John Templeton Foundation recently invited biologist Michael Levin to speak to a small group about the presence of agency and cognition in the most fundamental forms of life, even at the levels of cells and tissues. In the recorded video, Dr. Levin, who directs a developmental biology lab at Tufts University, discusses with Philip Ball, a science writer and author of the newly published Book of Minds: How to Understand Ourselves and Other Beings.
Founded in 1987, the John Templeton Foundation supports research and dialogue on the deepest and most perplexing questions facing humankind. The Foundation funds work on subjects ranging from black holes and evolution to creativity, forgiveness, and free will. It also encourages civil, informed dialogue among scientists, philosophers, theologians, and the public at large.
With an endowment of $3.8 billion and annual giving of approximately $140 million, the Foundation ranks among the 25 largest grantmaking foundations in the United States. Headquartered outside Philadelphia, its philanthropic activities have engaged all major faith traditions and extended to more than 57 countries around the world.
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