Lifeboat Foundation

Circa 2019

The evolution of micro and nanofabrication approaches significantly spurred the advancements of cardiac tissue engineering over the last decades. Engineering in the micro and nanoscale allows for the rebuilding of heart tissues using cardiomyocytes. The breakthrough of human induced pluripotent stem cells expanded this field rendering the development of human tissues from adult cells possible, thus avoiding the ethical issues of the usage of embryonic stem cells but also creating patient-specific human engineered tissues. In the case of the heart, the combination of cardiomyocytes derived from human induced pluripotent stem cells and micro/nano engineering devices gave rise to new therapeutic approaches of cardiac diseases. In this review, we survey the micro and nanofabrication methods used for cardiac tissue engineering, ranging from clean room-based patterning (such as photolithography and plasma etching) to electrospinning and additive manufacturing. Subsequently, we report on the main approaches of microfluidics for cardiac culture systems, the so-called “Heart on a Chip”, and we assess their efficacy for future development of cardiac disease modeling and drug screening platforms.

I’m so thrilled to present to you my debut work in documentary filmmaking! You can now watch my new film Consciousness: Evolution of the Mind in its entirety on major networks, such as Vimeo on demand, worldwide.

*Based on my recent book The Syntellect Hypothesis: Five Paradigms of the Mind’s Evolution. Enjoy!

https://vimeo.com/ondemand/339083

Guys! I’m so thrilled to present to you my debut work in documentary filmmaking! You can now watch my new film Consciousness: Evolution of the Mind in its entirety on major networks, such as Vimeo on demand, worldwide.

At the heart of almost every sufficiently massive galaxy there is a black hole whose gravitational field, although very intense, affects only a small region around the center of the galaxy. Even though these objects are thousands of millions of times smaller than their host galaxies, our current view is that the Universe can be understood only if the evolution of galaxies is regulated by the activity of these black holes, because without them the observed properties of the galaxies cannot be explained.

Theoretical predictions suggest that as these black holes grow they generate sufficient energy to heat up and drive out the gas within galaxies to great distances. Observing and describing the mechanism by which this energy interacts with galaxies and modifies their evolution is therefore a basic question in present day Astrophysics.

With this aim in mind, a study led by Ignacio Martín Navarro, a researcher at the Instituto de Astrofísica de Canarias (IAC), has gone a step further and has tried to see whether the matter and energy emitted from around these black holes can alter the evolution, not only of the host galaxy, but also of the satellite galaxies around it, at even greater distances. To do this, the team has used the Sloan Digital Sky Survey, which allowed them to analyze the properties of the galaxies in thousands of groups and clusters. The conclusions of this study, started during Navarro’s stay at the Max Planck Institute for Astrophysics, are published today in Nature magazine.

Laurie Graham, a molecular biologist at Queen’s University in Ontario and lead author on the paper, knows she’s making a bold claim in arguing for the direct transfer of a gene from one fish to another. That kind of horizontal DNA movement once wasn’t imagined to happen in any animals, let alone vertebrates. Still, the more she and her colleagues study the smelt, the clearer the evidence becomes.

Nor are the smelt unique. Recent studies of a range of animals — other fish, reptiles, birds and mammals — point to a similar conclusion: The lateral inheritance of DNA, once thought to be exclusive to microbes, occurs on branches throughout the tree of life.

Sarah Schaack, an evolutionary genomicist at Reed College in Portland, Oregon, believes these cases of horizontal transfer still have “a pretty big wow factor” even among scientists, “because the conventional wisdom for so long was that it was less likely or impossible in eukaryotes.” But the smelt discovery and other recent examples all point to horizontal transfers playing an influential role in evolution.

Many of the fundamental features of life don’t necessarily have to be the way they are. Chance plays a major role in evolution, and there are always alternate paths that were never explored, simply because whatever evolved previously happened to be good enough. One instance of this idea is the genetic code, which converts the information carried by our DNA into the specific sequence of amino acids that form proteins. There are scores of potential amino acids, many of which can form spontaneously, but most life uses a genetic code that relies on just 20 of them.

Over the past couple of decades, scientists have shown that it doesn’t have to be that way. If you supply bacteria with the right enzyme and an alternative amino acid, they can use it. But bacteria won’t use the enzyme and amino acid very efficiently, as all the existing genetic code slots are already in use.

In a new work, researchers have managed to edit bacteria’s genetic code to free up a few new slots. They then filled those slots with unnatural amino acids, allowing the bacteria to produce proteins that would never be found in nature. One side effect of the reprogramming? No viruses could replicate in the modified bacteria.

PROCEEDINGS OF THE ROYAL SOCIETY • JUN 3, 2021
Culture drives human evolution more than genetics

I wonder about the thought that only humans do this, and perhaps that somehow culture is separate in some way from biological evolution enmeshed with the rest of the planet?
by University of Maine

Culture is an under-appreciated factor in human evolution, Waring says. Like genes, culture helps people adjust to their environment and meet the challenges of survival and reproduction. Culture, however, does so more effectively than genes because the transfer of knowledge is faster and more flexible than the inheritance of genes, according to Waring and Wood.

Continue reading “Researchers: Culture drives human evolution more than genetics” »

The team says that the technique could be used to develop new vaccines against antibiotic-resistant bacteria, and potentially even wipe out some dangerous strains in a similar way to how smallpox was eradicated.

Pathogens like bacteria and viruses are extremely good at evolving in response to drugs, which can render vaccines ineffective. But now, researchers at ETH Zurich have found a way to weaponize that ability against them, forcing the bugs down harmless evolutionary dead ends.

Continue reading “Experimental vaccine forces bacteria down an evolutionary dead end” »

Full article available at: https://www.regenerativemedicinedaily.com/parasitic-worms… See More.

Humanity has a long and turbulent history with parasites, even today many parts of the world still struggle with rampant parasitic infections, with pathogens such as the malaria parasite claiming hundreds of thousands of lives every year. By their very nature parasites are harmful to our bodies, or at least that has been the prevailing opinion within the scientific community for as long as we have known of their existence. However, the malicious evolution of parasites might very well have produced a positive side effect which we are only just starting to notice.