Our body’s ability to detect disease, foreign material, and the location of food sources and toxins is all determined by a cocktail of chemicals that surround our cells, as well as our cells’ ability to ‘read’ these chemicals. Cells are highly sensitive. In fact, our immune system can be triggered by the presence of just one foreign molecule or ion. Yet researchers don’t know how cells achieve this level of sensitivity.
Now, scientists at the Biological Physics Theory Unit at Okinawa Institute of Science and Technology Graduate University (OIST) and collaborators at City University of New York have created a simple model that is providing some answers. They have used this model to determine which techniques a cell might employ to increase its sensitivity in different circumstances, shedding light on how the biochemical networks in our bodies operate.
“This model takes a complex biological system and abstracts it into a simple, understandable mathematical framework,” said Dr. Vudtiwat Ngampruetikorn, former postdoctoral researcher at OIST and the first author of the research paper, which was published in Nature Communications. “We can use it to tease apart how cells might choose to spend their energy budget, depending on the world around them and other cells they might be talking to.”
By bringing a quantitative toolkit to this biological question, the scientists found that they had a different perspective to the biologists. “The two disciplines are complimentary to one another,” said Professor Greg Stephens, who runs the unit. “Biologists tend to focus on one area and delve deeply into the details, whereas physicists simplify and look for patterns across entire systems. It’s important that we work closely together to make sure that our quantitative models aren’t too abstract and include the important details.”
On their computers, the scientists created the model that represented a cell. The cell had two sensors (or information processing units), which responded to the environment outside the cell. The sensors could either be bound to a molecule or ion from the outside, or unbound. When the number of molecules or ions in chemical cocktail outside the cell changed, the sensors would respond and, depending on these changes, either bind to a new molecule or ion, or unbind. This allowed the cell to gain information about the outside world and thus allowed the scientists to measure what could impact its sensitivity.
