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Deadly Germs, Lost Cures

In its decision to approve two drugs for orange and grapefruit trees, the E.P.A. largely ignored objections from the C.D.C. and the F.D.A., which fear that expanding their use in cash crops could fuel antibiotic resistance in humans.

An orange picker collecting oranges on a grove in Zolfo Springs, Fla. Credit Credit.

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A groundbreaking project to tackle one of the world’s most pressing and complex health challenges—antimicrobial resistance (AMR)—has secured a $1 million boost. UTS will lead a consortium of 26 researchers from 14 organisations in the development of an AMR ‘knowledge engine’ capable of predicting outbreaks and informing interventions, supported by a grant from the Medical Research Future Fund.

“AMR is not a simple problem confined to health and hospital settings,” explains project Chief Investigator, UTS Professor of Infectious Disease Steven Djordjevic. “Our pets and livestock rely on many of these same medicines, so they find their way into the food chain and into the environment through animal faeces.”

If left unchecked, AMR is forecast to cause 10 million deaths annually by 2050, and add a US$100 trillion burden to worldwide.

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Your mother was right: Broccoli is good for you. Long associated with decreased risk of cancer, broccoli and other cruciferous vegetables—the family of plants that also includes cauliflower, cabbage, collard greens, Brussels sprouts and kale—contain a molecule that inactivates a gene known to play a role in a variety of common human cancers. In a new paper published today in Science, researchers, led by Pier Paolo Pandolfi, MD, Ph.D., Director of the Cancer Center and Cancer Research Institute at Beth Israel Deaconess Medical Center, demonstrate that targeting the gene, known as WWP1, with the ingredient found in broccoli suppressed tumor growth in cancer-prone lab animals.

“We found a new important player that drives a pathway critical to the development of , an enzyme that can be inhibited with a natural compound found in broccoli and other ,” said Pandolfi. “This pathway emerges not only as a regulator for control, but also as an Achilles’ heel we can target with therapeutic options.”

A well-known and potent suppressive gene, PTEN is one of the most frequently mutated, deleted, down-regulated or silenced in human cancers. Certain inherited PTEN mutations can cause syndromes characterized by cancer susceptibility and developmental defects. But because complete loss of the gene triggers an irreversible and potent failsafe mechanism that halts proliferation of cancer cells, both copies of the gene (humans have two copies of each gene; one from each parent) are rarely affected. Instead, exhibit lower levels of PTEN, raising the question whether restoring PTEN activity to normal levels in the cancer setting can unleash the gene’s tumor suppressive activity.

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This year, the European Union heavily restricted four types of phthalates in consumer products because of their possible health effects. Phthalates are plasticisers, ubiquitous chemicals that soften plastics in many consumer products. They are present in food wrappings, clothes, packaging, car parts, cosmetics and fragrances.

Over time, these plasticisers end up in the air, soil, water, food and household dust. They can also end up in our bodies. This is worrying because they are implicated in reproductive abnormalities in mammals. Studies of people have linked plasticisers to sperm damage, lower fertility, early puberty in girls and thyroid effects. The phthalates will be now legally be restricted to 0.1% in weight in articles used by consumers or in outdoor areas.

But scientists are increasingly concerned not just about single chemicals, which are found in people’s bodies at levels that are usually not toxic, but about what happens to toxicity when these chemicals mix.

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Honey is a culinary staple that can be found in kitchens around the world. Its long shelf life and medicinal properties make it a unique, multipurpose natural product. Although it seems that a lot is known about the sweet substance, surprisingly little is known about its proteins. Check out research in the Journal of Natural Products with new data on honey proteins that could lead to new medicinal applications:


American chemical society: chemistry for life.

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Glyphosate, the primary ingredient in Monsanto’s popular weed killer Roundup, has been linked to liver disease in animal models. In a new study, the first of its kind, researchers at the University of California San Diego School of Medicine report an association between the herbicide and negative effects upon the human liver.

In a study published in Clinical Gastroenterology and Hepatology, a team led by Paul J. Mills, Ph.D., professor and chief in the Department of Family Medicine and Public Health at UC San Diego School of Medicine, examined excretion in the of two —those with a diagnosis of NASH (non-alcoholic steatohepatitis, a type of nonalcoholic fatty or NAFLD), and those without. The results, they found, were significant: Regardless of age, race, body mass index (BMI), ethnicity or diabetes status, glyphosate residue was significantly higher in patients with NASH than it was in patients with a healthier liver.

The findings, coupled with prior animal studies, said Mills, suggest a link between the use of commercial glyphosate in our , which has increased significantly over the past 25 years, and the prevalence of NAFLD in the United States, which too has been on the rise for two decades.

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University of Sydney research provides new evidence that nanoparticles, which are present in many food items, may have a substantial and harmful influence on human health.

The study investigated the impacts of food additive E171 ( nanoparticles) which is commonly used in high quantities in foods and some medicines as a whitening agent. Found in more than 900 such as chewing gum and mayonnaise, E171 is consumed in high proportion everyday by the .

Published in Frontiers in Nutrition, the mice study found that consumption of food containing E171 has an impact on the gut microbiota (defined by the trillions of bacteria that inhabit the gut) which could trigger diseases such as inflammatory bowel diseases and colorectal cancer.

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