Lifeboat Foundation

http://toosickandnaked.com/2018/05/07/25-the-future-of-medic…-bioquark/

China’s push into gene-editing crops sows unease in America’s heartland: Will U.S. farmers be shut out?

Chinese-owned Syngenta makes strides in new technologies to alter plant DNA, as U.S. farmers worry that cutting-edge agricultural science is shifting East.

A compelling study from a team of researchers at the University of Copenhagen has demonstrated a way to completely stop a body’s ability to store fat. In experiments with mice, the team showed that genetically deleting a single enzyme resulted in the animal not being able to gain weight, even when fed a fatty diet.

An enzyme dubbed NAMPT has been connected to obesity in both human and animal models by several studies. Its presence in fat tissue has been found to increase metabolic functionality in numerous body tissues, including fat tissue, which enhances the body’s ability to store fat.

“NAMPT in fat tissue was likely once an extraordinary benefit to our ancestors but in today’s society full of high-fat, calorically-dense foods, it may now pose a liability,” says Zachary Gerhart-Hines, a corresponding author on the study.

Continue reading “Deletion of single enzyme stops mice getting fat, no matter the diet” »

As if it’s not bad enough that bacteria are increasingly becoming resistant to our best antibiotics – some bugs are even eating the drugs. An international team of scientists has now examined just how the bacteria disarm and consume the antibiotics as food, uncovering new potential ways to fight back against resistance.

Bacteria are evolving resistance to antibiotics at an alarming rate, thanks to overprescription and overuse. If left unchecked, reports suggest that by 2050 the so-called superbugs could be responsible for up to 10 million deaths a year, ushering in a new dark age of medicine where our drugs simply don’t work.

Adding insult to injury, some species of bacteria flaunt their resistance by actually chowing down on antibiotics. New research out of the Washington University School of Medicine in St. Louis has set out to examine just how the bacteria manage to do this.

Purdue University scientists led a comprehensive analysis of research concerning the effects of microplastics on aquatic life, with the results showing widely different impacts among different types of animals. Strong negative effects were particularly apparent for small animals, such as larval fish and zooplankton, a source of food for many species, suggesting serious potential consequences that could ripple throughout the food web.

Tomas Höök, an associate professor in Purdue University’s Department of Forestry and Natural Resources and director of the Illinois-Indiana Sea Grant College Program, led a team that designed a meta-analysis of research related to the effects of microplastics on aquatic life. The analysis, published in the journal Science of the Total Environment, used results from 43 other studies that each considered the effects of microplastics on consumption of food, growth, reproduction, and/or survival of aquatic animals. The analysis mathematically calculated one or more effect size(s) for each study, then those effects were combined statistically to understand the big-picture effect on animals. The animals included in this study were all aquatic but ranged from fish to mussels to sea urchins to worms.

The most significant findings included:

Continue reading “Most microplastic harm done at lowest levels of food web, according to analysis” »

Poor countries tend to have out one-tenth of the crop yield per hectare compared to the yield from rich countries. Farmers in rich countries are more productive than those in poor countries because they use better technology and infrastructure, and are subject to better government policies.

If all the world’s farmers extracted the maximum potential output from their fields, the gap in yields between rich and poor countries would vanish almost entirely.

So what would it take for the developing world to catch up?

Continue reading “Poor countries can increase food production” »

Whole genome sequencing is more precise than other methods, and it just keeps getting faster and cheaper. Joel Sevinsky, head of the Molecular Science Laboratory at the Colorado Department of Public Health and Environment (CDPHE), told the Associated Press his lab can sequence the genome of a suspected pathogen in less than 72 hours.

Whole genome sequencing is already helping researchers address food-borne outbreaks, including a 2017 salmonella outbreak that stretched across 21 states, and the current romaine outbreak.

Continue reading “You Know That Romaine-Linked Outbreak? DNA Tech Is Fixing It” »

Before 1870, India barely had railroads. It didn’t have many canals either, and only a small percentage of the population lived along the three main rivers. So when goods needed to be transported, people used steer, which could pull freight about 20 miles per day.

But the British, India’s colonial rulers, started building rail lines, and then built some more. By 1930, there were more than 40,000 miles of railroads in India, and goods could be shipped about 400 miles a day.

The result? As MIT economist David Donaldson shows in a newly published study on the economic impact of building infrastructure, railroads fostered commerce that raised real agricultural income by 16 percent.

A new biotech company co-founded by CRISPR pioneer Jennifer Doudna is developing a device that uses CRISPR to detect all kinds of diseases like malaria, tuberculosis, and Zika. The tech is still just in prototype phase, but research in the field is showing promising results. These CRISPR-based diagnostic tools have the potential to revolutionize how we test for diseases in the hospital, or even at home.

Called Mammoth Biosciences, the company is working on a credit card-sized paper test and smartphone app combo for disease detection. But the applications extend beyond that: The same technology could be used in agriculture, to determine what’s making animals sick or what sorts of microbes are found in soil, or even in the oil and gas industry, to detect corrosive microbes in pipelines, says Trevor Martin, the CEO of Mammoth Biosciences, who holds a PhD in biology from Stanford University. The company is focusing on human health applications first, however.

Continue reading “This company is making an at-home CRISPR kit to find out what’s making you sick” »